An announcement earlier this week from revenue-generating specialty pharmaceutical company Recro Pharma, Inc. (NASDAQ: REPH) is good news for those suffering from pain after major surgery. From its headquarters in Malvern, Pennsylvania, the company announced positive results from a phase III clinical trial evaluating intravenous (IV) Meloxicam for the treatment of acute post-operative pain.

In this trial, the second of two phase III trials, IV Meloxicam achieved the primary endpoint of a statistically significant differential in Summed Pain Intensity Difference over the first 24 hours (SPID-24) in patients who had undergone abdominoplasty surgery, as compared to placebo. With the positive data from this study, the company believes this completes the efficacy program for IV Meloxicam and opens the way for a New Drug Application (NDA).

A report from Aegis Capital (http://dtn.fm/Kx7Za), released earlier this month when it initiated coverage on Recro Pharma, shows why this is a big deal. Aegis estimates the size of the U.S. post-operative pain market at around $5.9 billion. At present, many of the analgesics employed, such as morphine, codeine, and hydrocodone, are opioids. But such powerful anodynes are notoriously addictive and their use is often subverted from pain relief. According to the Centers for Disease Control (CDC), 29,000 Americans die every year from opioid-related overdoses.

Consequently, there is growing demand for less addictive pain medications, particularly in the post-op environment, where conventional pain management drugs such as morphine are still commonly used. In addition to being less addictive than morphine, IV Meloxicam can be delivered as a 15-second infusion and has been shown to have fast onset of action in clinical trials. As a result of these factors, Aegis expects peak year revenue for IV Meloxicam to be in the range of $150-200 million.

This trial focused on testing the efficacy of IV Meloxicam in combating pain following abdominoplasty surgery, a complicated procedure that generally involves the removal of excess fat and skin and may include the restoration of weakened or separated muscles from the abdominal area. The American Society for Aesthetic Plastic Surgery reports that abdominoplasty is among the top five most common cosmetic surgeries in the U.S., with more than 164,000 performed in 2014. It is a procedure that, typically, results in intense postoperative pain.

In July, Recro announced positive top-line data from the IV Meloxicam (30 mg dose per 24 hours) in bunionectomy phase III trial. This first phase III trial measured its primary endpoint in terms of Summed Pain Intensity Difference over 48 hours (SPID-48) and showed a statistically significant reduction in SPID-48 versus placebo. It also achieved statistical significance across 15 of 19 secondary endpoints.

With the successful completion of these two phase III trials, an NDA is expected to be filed in summer 2017, followed by potential FDA approval in mid-summer 2018.

Recro Pharma is a clinical development-stage pharmaceutical company geared toward the development of non-opioid treatments for the management of acute pain in hospital and ambulatory care (outpatient) settings. The company currently earns revenue from a contract manufacturing, royalty and formulation business in Gainesville, Georgia, acquired in April 2015 from Alkermes, the Irish drug maker. Its lead product candidate, IV Meloxicam, is a cyclo-oxygenase 2 (COX-2) inhibitor, exclusive worldwide rights to which were acquired as part of the 2015 Alkermes deal.

Aegis originally put a price target on Recro Pharma stock, currently trading on the NASDAQ at around $9.00 under the symbol REPH, of $21.00. This was based on a 70% probability that the abdominoplasty phase III trial would be successful. With that study yielding such decidedly positive results, the price target was raised to $25.00 in an updated report (http://dtn.fm/Lvu6Y).

For more information, please visit www.RecroPharma.com

Before the opening bell, Dominovas Energy Corporation (OTCQB: DNRG) announced the completion of a recent business trip to the Republic of Madagascar. The visit, which coincided with the Francophonie Summit 2016 in the nation’s capital city of Antananarivo, featured continued discussions between Neal Allen, chairman and CEO of Dominovas Energy, and officials within the Madagascan government regarding the potential deployment of a “nation-changing” 650MW power plant. According to this morning’s update, it’s anticipated that Dominovas Energy and the Government of Madagascar will soon enter a binding Memorandum of Agreement that defines the specific deliverables and responsibilities of each party as it pertains to the installation, deployment and operation of this power plant within the company’s BOOTT (Build, Own, Operate, Train, Transfer) construct.

“Several countries were considered by Dominovas Energy as a possible ‘ground zero’ for this power plant, but Madagascar has exhibited an unyielding commitment to this project from the initial introduction of the opportunity and has put in place exceptionally competent people to shepherd this project,” Allen stated in this morning’s news release. “From the beginning, President Rajaonarimampianina recognized the significance of this project and further, if successfully deployed, its paramount importance for Madagascar’s short and long term national development.”

News of the Madagascar meetings closely follows Dominovas Energy’s filing of a Form 8-K chronicling the execution of a reciprocal letter of interest (LOI) with the Madagascan government for the deployment of a baseload power supply. After meeting with several key officials within the nation’s government, including President Hery Rajaonarimampianina and Minister of Energy Lieutenant-General Herilanto Raveloharison, Dominovas Energy will now turn its attention toward perfecting all feasibility studies related to the proposed 650MW power plant before executing the documents required to support a successful financial close in 2017. The company expects to secure the requisite funding within the next several months ahead of the subsequent commencement of construction operations.

For the Republic of Madagascar, installation of this power project is expected to present substantial macroeconomic benefits. In addition to ending the country’s long-standing energy deficit, which has been a primary goal of President Rajaonarimampianina, the energy capacity generated through this installation could serve as an ignition source for local mining, manufacturing and resort enterprises, effectively energizing and supporting Madagascar’s national economy. Comprehensively, the increase in power production that could stem from this agreement, along with the anticipated revival of the manufacturing and mining sectors, is forecast to play a key role in the creation of more than 3,000 construction jobs and a “significant number” of long-term employment opportunities.

“This project is of paramount importance for Madagascar’s national development,” continued Allen. “Dominovas Energy’s investment will support a multitude of opportunities moving Madagascar from its current modality, to a substantial global economic competitor. We are honored and equally excited to have the privilege to begin this journey with Madagascar.”

For more information, visit www.DominovasEnergy.com

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As the entire real estate industry is changing fast, with the advent of technology and enhanced interconnectivity set to significantly alter the sector’s business customs, GainClients, Inc. (OTC: GCLT) is staying ahead of the curve with its GCard networking system (http://dtn.fm/mQx7D), which is designed to help real estate professionals better connect and communicate with their customers. With a growing number of real estate customers opting for online and mobile real estate solutions, GCard is a progressive integrated networking system that allows real estate brokers and agents to provide their customers with a wealth of information, including property details, lending requirements, title services and more.

The GCard works like most popular online networks, with real estate professionals being able to invite industry partners and customers to join their networks and become members of their teams. This ensures enhanced communication between team members and efficient sharing of relevant information to a customer during the process of selling or buying a home. The relevant info can be sent to the customer’s phone directly via a special app designed to work with most mobile devices. Customers can get the app via text or email from their real estate agent.

Using the GCard network comes with multiple benefits for real estate professionals, as they are given access to various features designed to help them understand their customers and their requirements so as to eventually offer them the best possible service. These features include relevant data about a client’s activity preferences, such as homes viewed and favorited with live links to the properties, as well as a newsletter scheduler and customization tools. Real estate agents using the GCard app can also access a detailed view of their history, with recently added clients and partners, partner referrals, and partner information.

With the purpose of further expanding the GCard platform, GainClients recently sealed a worldwide licensing agreement with real estate tech upstart CLOVIS, LLC under which the latter will develop a lead generation program for the real estate advertising and marketing industry. The partnership has the purpose of ultimately enabling the distribution of proprietary technologies from both parties to the real estate industry, with an eventual equal profit share and a 19 percent equity exchange in the foreseeable future.

In addition to the GCard networking system, GainClients also offers a stand-alone website, GCHomeSearch (http://dtn.fm/AOI6o), that provides listing data, historical property info, demographics and neighborhood information. Although primarily destined to customers outside of the real estate realm, GCHomeSearch can be used together with GCard to provide users with various tools such as loan payment calculators, cost estimators, loan rates and other features to help home buyers or sellers make informed decisions.

For more information, visit the company’s website at www.gainclients.com

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After a long journey in which no efforts were spared, China’s online-to-offline integrated social media operator, Moxian, Inc. (NASDAQ: MOXC), was officially uplisted earlier this month when its common stock began trading on the Nasdaq Capital Market. To mark this moment, the company’s management traveled to New York City to ring the Nasdaq Trade opening bell last Wednesday, on November 23.

The event at the Nasdaq MarketSite in Times Square was attended by CEO and Chairman James Tan and Executive Director Hao Qing Hu. The pair rang the trade opening bell at 9:30 a.m. ET to mark the beginning of the Wednesday stock market trading session and also in honor of their company’s recent Nasdaq uplisting. Tan said he and his team were very honored by this achievement, as it reflects the hard work of everyone at his company in their efforts to get investors’ attention and increase shareholder and corporate value.

Founded in 2013, the company began preparing for the Nasdaq uplist earlier this year with two U.S. Securities and Exchange Commission filings required for this upgrade: a securities registration statement and a reverse stock split. The Chinese company had been trading on the OTCQB Venture Marketplace since 2014. To further help with the company’s efforts, Tan put together a strong team with more than 100 years of combined experience in various industries and technologies. The company’s management team has experience with both public and private companies in Asia and the U.S., while Tan himself is a highly-experienced manager who has occupied executive positions with various public companies, including Pacific Internet, Ltd., a formerly NASDAQ-listed company.

Moxian markets an O2O integrated platform operator that primarily targets small- and medium-sized enterprises to help them connect with customers and prospects. The social commerce platform integrates social media features, gamification and entertainment, as well as business intelligence capabilities, being built around the company’s proprietary Social Customer Relationship Management tool. The Social CRM was created with the purpose of improving interaction between businesses and consumers by enabling merchants to run targeted advertising and marketing campaigns.

Merchants can gather and analyze relevant behavior data about their customers via the Moxian+ Business app, with the goal of understanding their audiences better and offering every user group a more personalized experience. The user information is gathered via the Moxian+ User app, dedicated exclusively to shoppers. This app includes a game center, a rewards redemption center and social media networking capabilities. It can further make personalized shopping recommendations based on geolocation and a user’s saved preferences. Both apps are available for Android and iOS devices.

For more information, visit the company’s website at www.Moxian.com

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According to The National Association of Realtors (http://dtn.fm/Ct9j5), this October was the second month in a row to show incredible sales peaks in existing home sales, registering the highest sales rate in nearly 10 years. With existing home sales skyrocketing for yet another month, it is no surprise that real estate agencies are looking for ways to maintain a competitive edge, anxious to better serve their customers based upon preferences and demographics. eXp World Holdings, Inc. (OTCQB: EXPI), the holding company for eXp Realty LLC, a unique agent-owned cloud brokerage, believes in just this. In order to maintain a competitive edge, EXPI stays up-to-date with not only the current geopolitical and economic changes in both the U.S. and Canada but also the volatility in various markets, employment rates, and all technological changes.

The National Association of Realtors published an article, entitled ‘Protecting Your Brand Online: Social Media Tips for Real Estate Professionals’ (http://dtn.fm/8uHp8), which highlights the importance of maintaining a strong position within the virtual world. EXPI works through a cloud office environment, allowing brokers and agents to work, attend classes, strategize, and collaborate through a virtual medium while efficiently serving customers in their search for a new home. The company is the first truly agent-owned brokerage, allowing it to increase broker and agent listings and sales while reducing overhead costs.

However, the changing real estate scene is not just about advances in technology. The diversity of future homebuyers is expected to transform the real estate industry as a whole. During the buyer preferences forum (http://dtn.fm/U0vFV), organized by Realtor University, professionals discussed the changing demographics in the U.S., new home preferences, and the livability needs of current and future home buyers. According to the research, nearly every generation has a strong desire to own their own property. The article pointed out that, despite technological advancements, “This tough environment for buyers and sellers further demonstrates the importance of real estate businesses being based on relationships and face-to-face interactions.”

eXp World Holdings combines advanced technology from its cloud-based environment with the value that consumers see from working face-to-face with professionals. Because many future home buyers start their searches online, the company cuts costs by cutting out physical brick and mortar offices, yet maintains a high level of service by navigating the home buying process with clients while giving information and comparative perspective on properties. Agents at EXPI provide local market expertise, negotiating and advocating on their clients’ behalf.

For more information, visit the company’s website at www.eXpWorldHoldings.com

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New York-based Axsome Therapeutics, Inc. (NASDAQ: AXSM) is tending to a major and thriving market where current treatment options are insufficient. This young company (founded in 2012) is striving to establish a fully-integrated biopharmaceutical business that will develop and bring to the healthcare marketplace therapies for the management and treatment of central nervous system (CNS) disorders.

Axsome Therapeutics has a laser-like focus on differentiated therapies, in particular. To improve the lives of patients living with pain and various CNS disorders, Axsome has set its sights on working with both internally-derived drug candidates and in-licensed drug candidates in order to create a path to development and commercialization that will, ultimately, expand the treatment alternatives available to caregivers.

Axsome Therapeutics has moved into the clinical stage at this time. It holds a product candidate portfolio that includes two late-stage candidates, AXS-02 and AXS-05, which it is developing for multiple indications, as well as AXS-06.

• AXS-02, a non-opiod therapeutic in development for chronic pain, is Axsome’s leading product candidate. It is currently being evaluated in phase III trials for the treatment of complex regional pain syndrome, knee osteoarthritis with bone marrow lesions (BMLs) and chronic low back pain with modic changes.
• AXS-05 is a fixed-dose combination of dextromethorphan and bupropion, both of which have shown to be effective in activating central nervous system receptors. AXS-05 is currently in a phase III trial indicated for treatment resistant depression and agitation in patients with Alzheimer’s disease.
• The company is also developing AXS-06 for the treatment of chronic pain disorders.

Analysts have pointed to the value in Axsome’s focus on complex regional pain syndrome, treatment resistant depression and agitation in patients with Alzheimer’s disease, indicating that these disorders possess lower-than-average research and development risks and a tested business model that leans toward a faster commercialization timeline (http://dtn.fm/Urt7t).

For more information, visit www.Axsome.com

The travel industry is growing exponentially, but must also be ready to become more flexible and make more changes to cater to the needs and requirements of the market segment currently driving its growth – the Millennials. This new generation of travelers has hit an average annual spending of $200 billion on tourism and travel, according to a FutureCast report titled ‘Millennial Brief on Travel & Lodging’ (http://dtn.fm/Rf12j). The figure is the largest average the tourism industry has ever seen, a trend that’s likely to be maintained, provided that the industry’s operators are able to meet the needs of this group of tourists.

Having reached adulthood in the 2000s, at the peak of the Internet age, it is no wonder that Millennials thoroughly research their options and destinations when making travel plans. According to the FutureCast report, Millennial tourists check an average of 10 sources before they make a travel purchase. This habit is also a result of this group of travelers’ collective desire to experience something utterly new and unique on their trips. Perhaps more than any other generations, Millennials are primarily interested in new, personalized experiences on their travels rather than just relaxing or sightseeing, with nine out of ten in agreement.

Additionally, 70 percent of Millennials are interested in exploring the communities they visit during their vacations in order to learn something new about them, mingle with them and experience life as they would. This also reflects their lodging preferences, with more and more Millennials opting for alternative lodging rental units when they travel instead of more traditional solutions such as hotels. It is no surprise that a growing number of Millennials use online platforms such as Airbnb or Booking.com to research their lodging options and make a booking before they travel.

Monaker Group, Inc. (OTCQB: MKGI), a technology-driven tourism company offering comprehensive travel solutions and personalized tours, is ready to tap into this fast-growing travel market segment by offering not only an impressive portfolio of alternative lodging rental units but also access to full-service tours to hundreds of destinations around the world.

The group currently has a portfolio of more than 1.1 million alternative lodging rental units available under its NextTrip Resorts platform, and it is currently in the process of adding more than 200,000 timeshare and resort units by the end of the year. Via its flagship NextTrip.com platform, Monaker allows tourists to plan their trips to the smallest details by offering them access to a wealth of alternative lodging options, such as unused timeshare inventory, resort residences and vacation home rentals, as well as a wide range of hotels, rental cars, tours, airlines, concierge services and more.

The platform, launched in February 2016, has grown exponentially, being the only real-time booking engine that combines various booking options to meet tourists’ every need. With Millennials’ influence on the travel industry set to expand further over the coming years as this population segment continues to grow, full-service booking platforms such as NextTrip.com are likely to become an increasingly important part of the industry.

For more information, visit www.MonakerGroup.com

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At last month’s MicroCap Conference in Philadelphia, the technological prowess of OurPet’s Company (OTCQX: OPCO) was on display. A presentation (http://dtn.fm/1oSgo) by the company’s chief financial officer, Scott Mendes, showed the many innovative products for cats and dogs, who are the rainmakers of OurPet’s Company. The CFO also gave an account of OPCO’s history of growth, from its genesis in 1985 as Napro, Inc. to the present. The company has grown both organically and through acquisitions. CEO Dr. Steve Tsengas wants to double its size and, to support that expansion, has invested heavily in distribution and marketing infrastructure.

The company was founded in 1994 by chairman and CEO Dr. Steve Tsengas and chief operating officer Dean Tsengas. Dr. Steve Tsengas is an enterprising engineer who has been elected to the National Inventors Hall of Fame. In a past MissionIR OPCO interview (http://dtn.fm/5kLUU), he revealed that one rationale behind the founding of OurPet’s Company was the lack of innovation in the pet industry back in the 1990s. As a result, a decision was made to concentrate on creating truly novel products that solved problems for pets and pet parents, along with the marketing and distribution of those products, rather than manufacturing. Since its inception, OPCO has stuck to that mission and successfully passed many mirthful milestones.

In 1994, its first product, the Big Dog Feeder®, which made it easier for big dogs to eat by elevating the feeding bowl, created quite a stir at a classic pet show in Cleveland, Ohio. Three days after its debut, the feeder recorded sales of about $6,500. In 2001, the company became publicly traded on the Over-the-Counter Bulletin Board under the symbol OPCO. OPCO continued on this inventive path by acquiring or creating brands like the Play-N-Squeak®, Cosmic Catnip™, Go! Cat! Go!®, Durapet®, SmartScoop® and Flappy®. In 2014, it launched its dual brand strategy with OurPets® and Pet Zone®. Products under the OurPets® brand are targeted at pet specialty retailers, while those under the Pet Zone® brand are distributed through the food, drug and mass retail channels.

Now, OurPet’s Company is set to exploit the amazing possibilities offered by new digital technologies with its OurPets® Intelligent Pet Care™ (http://dtn.fm/0Hcpa) product line. This suite of products is designed to help parents monitor their pets by employing a combination of infrared (IR), Bluetooth and Wi-Fi technologies.

OurPet’s Company has been growing much faster than the industry as a whole. Since 2010, it has had an annual compound growth rate (CAGR) of about six percent, while the industry has experienced a more modest four percent. The company’s earnings before interest, taxes, depreciation and amortization (EBITDA) have increased from $403,761 in Q1 2014 to $958,263 in Q3 2016, while net income has increased by 269 percent over the same period, from $134,427 to $495,669. The cats and dogs at OurPet’s Company are racing ahead like cheetahs and greyhounds.

For more information, visit the company’s website at www.OurPets.com

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Chanticleer Holdings, Inc. (NASDAQ: HOTR) kicked off November with the announcement that, during the fiscal quarter ended September 30, 2016, the company achieved its second consecutive quarter of adjusted EBITDA profitability. This milestone came alongside an 18.3 percent year-over-year increase in total revenue, which was attributed primarily to Chanticleer’s rapidly expanding fast casual better burger segment. In a news release, Mike Pruitt, chairman and chief executive officer of Chanticleer, noted that the company’s Little Big Burger restaurants were performing “particularly well” before adding that the brand contributed “significantly to the 19% sequential growth in Adjusted EBITDA from continuing operations” and further validated Chanticleer’s regional brand strategy.

With this regional brand strategy at the forefront of Chanticleer’s near-term growth efforts, it came as little surprise when, before the opening bell on Monday, the company announced plans for the launch of a new Little Big Burger restaurant in Portland, Oregon. The grand opening of the new location, which will be Chanticleer’s ninth Little Big Burger and 40th fast casual better burger store, is set to take place next week in Oregon’s largest city, whose metropolitan area is home to roughly 60 percent of the state’s overall population. Pruitt used Monday’s news release to speak toward the company’s excitement ahead of next week’s grand opening.

“We are very pleased to open up a new Little Big Burger in the Portland area,” he stated. “This store is our first store opening financed with EB-5 capital, which provides attractive, non-dilutive capital to expand our regional brands. Little Big Burger has been performing well with particularly attractive store economics, and we look forward to continuing to strategically utilize EB-5 financing for additional Little Big Burger restaurants as well as our other regional brands.”

As referenced by Pruitt, EB-5 capital stems from a federal government program created to encourage foreign investment in U.S. businesses. In addition to serving as one of the fastest methods for foreign investors to gain permanent residency in the U.S., the program is used nationwide to finance the construction and development of new projects in an increasingly diverse number of industries. EB-5 financing is particularly attractive to those operating within the hospitality sector, as it provides a low cost alternative to more traditional sources of capital while typically presenting favorable financing terms that result in reduced financial risk.

Chanticleer’s newest Little Big Burger restaurant will be located in Portland’s bustling Lloyd District at 1088 NE 7th Avenue.

For more information, visit www.chanticleerholdings.com

Hollywood-based entertainment technology company bBooth, Inc. (OTCQB: BBTH) is set to disrupt the entire Software-as-a-Service (SaaS), Customer Relationship Management (CRM), and sales lead generation software industry with its novel bNotifi platform. With bNotifi, marketers get two boons for the price of one. First, marketing reach is expanded with the employment of virtual representatives and, second, the message gets told with motion pictures, which, as we now know, are worth much, much more than a thousand words. The bNotifi technology has completely re-invented what a CRM, lead-generation tool should be in today’s video-centric social environment.

If, in today’s online marketing realm, content is king, then video must surely be the crown. A feature this month on Search Engine Watch (http://dtn.fm/xIl5F) predicts ‘that video will account for 69% of all internet traffic by 2017.’ It goes on to say ‘for brands, video content is a powerful way to introduce themselves, spread their message, promote a product, increase their reach, boost engagement, and explain their service.’

The company that eschews video in the marketing mix risks missing the boat. eMarketing reports that ‘during mid-2015, online video overtook social media relative to the amount of time spent per day online’. And a survey from HighQ confirms this: ‘…approximately 55% of Americans watch online videos every day, with the average American adult spending one hour and 16 minutes each day watching video on digital devices. Growth relative to this area has been staggering as consumers spent only 21 minutes per day watching online videos in 2011.’

bBooth CEO Rory J. Cutaia is certainly aware of these trends, but points out that ‘video marketing is no longer (just) about YouTube videos or brands distributing clips on social media’.

“More and more thought leaders have begun to recognize that targeted interactive video communications that track the level of viewers’ actual engagement is far and away more effective in generating, and more importantly, in recognizing hot sales leads,” argues Cutaia in a press release (http://dtn.fm/n5y1O).

The bNotifi platform originated from bBooth’s mall-based kiosks and mobile apps that were focused on talent discovery (http://dtn.fm/k9NfU). The technology has been improved and upgraded to a cloud-based, enterprise level SaaS platform, developed to address a much larger target market that includes celebrities and sports personalities, corporate users, consumer brands and media companies. The bNotifi technology represents a new innovative platform for CRM, lead-generation, advertising, fan engagement, and consumer brand activation.

Through fully integrated mobile, desktop, and web-based applications, the bNotifi technology provides push-to-screen, media-rich, interactive audio and video messaging and communications for higher levels of social engagement and interactive online training and teaching applications, as well as an enterprise scale lead generation and customer retention platform for sales professionals and others.

The bNotifi platform also includes a robust back-end administration console with data collection capabilities, among other features, designed to provide small, medium and large-scale enterprise users, among others, with the ability to send, receive and manage enhanced, media-rich, highly-engaging messaging for both internal and external communications.

In September, bBooth announced it had agreed to provide The Matrix Group, and its 890,000 independent representatives in affiliate organizations, with the bNotifi CRM and Lead Generation technology. And in October, The Matrix Group began a global launch of bNotifi, which will give its associates the power to engage customers and prospects in an entirely new, interactive media-rich format. Building on this progress, BBooth announced the release of bNotifi 2.0 earlier this month.

For more information, visit www.bbooth.com