Marketing professionals are invited to take their outreach to the next level at the 4th Digital Marketing In Life Sciences conference, streaming online February 15-16, 2023. The agenda focuses on new digital channels, creating interesting and informative content, and data acquisition to improve customer personalization in an evolving and competitive digital marketing arena.

The event is organized by Dynamic Global Events (“DGE”), a leading life science b2b event organizing company. The 4th Digital Marketing in Life Sciences conference will be streamed live on a trusted interactive platform. Life science experts of global acclaim will attend the event to share their expertise and valuable insights. They will offer their views on successfully building multimedia and other digital strategies to stay relevant. The evolving life science marketing landscape makes it vital to design futuristic digital marketing strategies.

In an ever-changing social networking scenario, marketing professionals must confidently understand and navigate the metaverse and short-format videos, as well as deal with questions surrounding whether to personalize data or prioritize relevant data. At DGE’s 4th Digital Marketing in Life Sciences Conference attendees gain exposure to deep insights and novel case studies for building successful multimedia strategies. The end result will be easier engagement with potential audiences on social platforms.

Other topics at the conference include:

• Making digital accessibility a priority
• Leveraging short-term video marketing while complying with regulations
• Understanding VR technology and identifying associated pros and cons
• Tapping the potential of metaverse
• Safeguarding your marketing strategy against post-pandemic HCP burnout

As elements like Metaverse take a front seat in digital marketing, patients and employees need ample digital accessibility and flexibility, and must stay updated with new technologies and evolving marketing strategies. Biotech, pharma, and med device companies have to evolve and adapt these novel techniques to engage with the audience.

As short-term videos grow more mainstream, life science marketing experts have to be trained in the unique approaches for this format. Marketing experts must also be adept with VR technology and identify the relevant marketing strategies that increase their audience engagement and conversions.

To learn more, please visit https://ibn.fm/m1sQw. https://nnw.fm/FFGYP.

Mining companies, businesses, suppliers, and professionals are all invited to attend the Future Of Mining Sydney 2023 conference being held on February 20-21st. With the pressure of sustainable mining options and conserving energy growing on mining companies, there is a growing need for new ways to conduct business while keeping profits intact.

At the Future of Mining Sydney conference, experts will discuss the challenges and feasible solutions for conducting mining operations in a no-harm, zero-emission sustainable way.

Join in for 20+ hours of networking where 350+ mining executives make their presence to discuss and share practical and thought-provoking ideas to address these mining solutions. Around 600+ attendees are expected to attend the 2-day event with 50+ stalwarts of the mining spectrum residing as keynote speakers. They will bring to light the pressure faced by the mining industry and put forth their ideas of green mining, operational efficiency, and responsible business.

Mining executives and companies can avail this huge opportunity to interact with industry regulators, experts, and investors. These two days of networking will pave the way for new business alliances and long-term relationships.

Important topics of discussion include:

• Technology and innovation
• Zero-entry mine: Surface and underground
• Incorporating real-time AI for process optimization
• Sustainable and responsible business
• Net zero mine to achieve green mining
• Embedding ESG into businesses
• Data analytics and digitalization of mining businesses
• Effective business management for cost curtailing
• Improving connectivity and strengthening the supplier chain for operational efficiency

The Future of Mining Sydney 2023 will witness an exceptional audience from the Australian mining arena to network and discuss fresh ideas for incorporating into their mining business. A varied panel of speakers will talk about the technological developments, innovations, and industry challenges in the various aspects of the mining industry. Join over 250 mining companies’ experts and hear from high caliber speakers such as:

• Hon Madeleine King MP, Minister for Resources, Australia
• Michelle Ash, Chief Technology Officer, OZ Minerals
• Ned Howard, Manager Geoscience, Evolution Mining
• Robyn Dittrich, Vice President, Procurement – Global Functions & China, BHP
• Fiona Robertson, Non-Executive Director, 29Metals/Bellevue Gold/Whitehaven Coal
• Ali Soofastaei, Artificial Intelligence Program Leader, Vale
• Malcolm Shang, Global Head of Mine Closure Planning and Circular Economy (Mining), ArcelorMittal and much more….

The Sydney Masonic Centre plays host to Australia’s premier events and conferences. The building presents 13 fully accessible event spaces that can accommodate small workshops and training sessions, conferences, VIP dinners, and cocktail events. Large-scale business events, meetings, exhibitions, live music, performances and special events of all kinds are organized at this venue.

An impressive lineup of presenting companies will showcase their businesses’ ideas to an engaging audience of industry leaders, investors and other mining businesses. Attendees get an opportunity for one-on-one meetings and personalized discussions with eminent investment groups, regulators and veterans businesses. 

The Future of Mining events is organized by Aspermont Media, London, England.

To learn more, please visit https://ibn.fm/Ft0vG.

Businesses, marketers, social media professionals, and enthusiasts, are invited to attend the Social Media Strategies Summit on February 21-24, 2023. This virtual event will be attended by senior-level social media industry professionals and influencers who will share their expertise for successful social media marketing.

SMSS is a leading event organizer of social media conferences for a wide gamut of businesses and services. They aim to foster networking and engagement with a targeted audience of decision-makers. Senior marketing professionals with many years of experience will offer time-tested tips on social media strategies that they successfully employ for reaching a wider niche audience. Attendees can harness the potential of this social media platform for communicating and establishing long-term business ties in the social media marketing industry.

Here are some new highlights of the conference:

• Along with networking and social media discussions, the conference will feature an additional day dedicated to brands who want to pitch their businesses and grow their online presence.
• Intimate group video discussions among peers led by speakers to discuss the most important topics in social media.
• Participants can attend the pre-summit workshop conducted by industry experts. Limited seats!

The summit will host a mix of eminent social media marketers who have spearheaded successful social media campaigns to attain success online.

Here are 6 reasons for attending the SMSsummit this year:

• Learn the winning strategies to execute social media campaigns for your brand for all sizes and budgets of businesses.
• Learn from the cross-industry case studies to understand the best opportunities for your brand across platforms like Instagram and Tiktok.
• Access and audit your social media brand strategies to stay ahead of your competitors.
• Boost brand awareness and loyalty by revamping or launching your brand’s social media campaigns.
• Understand what drives the audience, explore avenues to grow your reach and discover new audiences that engage with your brand.
• Learn tips from industry influencers and cultivate tools and robust social media strategies to stay relevant and fresh in the competitive arena.

Engage with social media marketers and industry leaders to know what’s new and understand what is driving the audiences. Learn from winning case studies and engage with the industry’s top social media leaders to leverage opportunities in the social media realm.

To learn more, please visit https://ibn.fm/UZ0T1.

• Cyber attacks remain a persistent and potentially costly threat to the successful operations of companies and government organizations
• While small to medium-sized businesses (“SMBs”) may be unable to manage the costs of hiring full-time cybersecurity experts, an emerging trend is supplying virtual chief information security officer (“vCISO”) services on a contract basis
• SideChannel Inc. provides vCISO consultancy and proprietary software for microsegmentation needs, drawing on years of experience in the cybersecurity arena
• SideChannel CEO Brian Haugli recently addressed important elements of vCISO client relations on the Cyber for Hire podcast, including expertise, geographical accessibility, and financially sound controls-based strategies

Cybersecurity experts in a wide variety of organizations have already issued lists of the top threats they anticipate for 2023, acknowledging the persistence and state of flux of cyber attacks worldwide. In particular, ransomware attacks lead to companies effectively being held hostage by cyber criminals demanding a reward before they will cease their attacks on the company and allow it to resume full use of its operational platform. The Des Moines Public School district, one of the most recent school districts to be targeted by such an attack, found itself compelled to cancel classes this month while the problem was addressed by IT staff, and announced that the school year in Iowa’s largest district will be extended into June to make up for lost class time (https://ibn.fm/YVExy). The U.S. Bureau of Labor Statistics expects the demand for cybersecurity workers to remain high with significant earnings through 2031 (https://ibn.fm/Wht8x), despite nearly 175,000 layoffs reported among the larger tech worker sector during the past year (https://ibn.fm/JHgaZ). The outsourcing of cybersecurity needs to virtual chief information security officer (“vCISO”) services is an emerging trend that provides affordable security staffing on a contract basis to those SMB companies that might find their budgets too small to employ an in-house cyber expert while recognizing the importance of having a security strategy in place. Cybersecurity services and technology provider SideChannel (OTCQB: SDCH) draws on years of experience in the sector to provide especially effective vCISO solutions to its clients, and CEO Brian Haugli recently discussed the decisions that go into a successful working relationship between vCISOs and clients in an interview with the Cyber for Hire podcast. “Our clients usually come to us — CFOs, CEOs, CTOs — and they basically say, ‘I don’t know what I need to do around cybersecurity, I just know I need to do the right thing. I need a risk management capability. I know I need it, but I don’t know how to get there,’” Haugli told the podcasters (https://ibn.fm/2IPtm). “And it’s almost like they’re asking me, ‘Tell me the right questions I should be asking you, and then I’ll be able to better figure out if you’re the one I want to work with based on how you led me through that journey.’” During the course of the 40-minute podcast, Haugli addressed the importance of ensuring vCISOs are expert enough to understand the cultural needs of the client (can a healthcare tech expert flexibly adapt to the security needs of a manufacturing client, for example), working within a reasonable geographic region (does an East Coast cybersecurity expert really expect to be fully available on a West Coast client’s schedule?) and recognizing how to establish a strategic vision for the client in a budget-conscious manner. Although some companies may want to place an emphasis on tracking their return on investment (“ROI”) from cybersecurity, as Forbes recently opined (https://ibn.fm/nFovi), Haugli rejected the idea of using ROI as a basis for the financial policy underlying cybersecurity strategy. “But, we are very much involved in, and should be involved in, setting the budget, whether it’s working with the CIO or the CTO or whomever it is,” Haugli said. “That should be objectively created based on gaps that you have identified in your current state on your path to your target state.” As an example, Haugli cited a scenario in which a company is trying to meet cybersecurity industry standards established by the National Institute of Standards and Technology Cybersecurity Framework, in which 108 potential security controls for the client’s operation are identified but only 99 are actually applicable to the client, and the client is already doing 89 of them. “Which means we have 10 to do. This is like simple math,” Haugli said. “I have to meet (with the client) and figure out how to address those 10 gaps. OK. Now I know where my direction should be on what to go purchase, what should I go fund. Based on control objectives. … Having a control-based kind of approach allows you to actually have that conversation with the CFO where they can go, ‘OK the thing you’re going to buy that you need $100,000 (for) is going to do eight of the 10 controls that we have gaps on. I get that, that makes sense.’” For more information, visit the company’s website at www.SideChannel.com. NOTE TO INVESTORS: The latest news and updates relating to SDCH are available in the company’s newsroom at https://ibn.fm/SDCH

• Utopia VR in April 2022 launched its global metaverse platform
• The company’s business model is focused on the future of work, enterprise and corporate remote office solutions
• Utopia VR’s management team has extensive experience in technology and public and private financial markets
• Utopia VR’s mobile app is now available for iPhone and iPad, with an Android release expected in early 2023
• The company has passed the beta stage and is now generating revenue

Utopia VR is one of the world’s first ‘Metaverse-As-A-Service’ solutions for business. The company’s hosted and managed subscription software provides businesses a low barrier to entry, browser-based, device agnostic platform where they can manage their own private 3D metaverse meeting spaces. Users can host and attend Zoom-like virtual meetings in lifelike virtual reality – with no software downloads – engaging their audiences in a more collaborative and fun way.

Utopia VR has many technology and privacy advantages over solutions built on other metaverse marketplaces such as Horizon Worlds (“META”) or Decentraland. Utopia VR works on all devices – PC, mobile and virtual reality headsets – whereas many competitors only work in VR or on PC.

Utopia VR is headquartered in Kelowna, B.C.

Products

Utopia VR’s The Metaverse for Everyone(TM) is a one-click, web-based, avatar-driven, mobile-friendly audio- and video-conferencing platform that utilizes innovative 3D web technology. Utopia VR’s virtual platform works on digital devices including PCs, mobile phones and VR headsets such as Oculus Quest or HTC Vive. No software or proprietary hardware is needed.

Users navigate through the various VRoom environments by using avatars. Users can walk, talk and sit – just like they do in the real world. A user’s avatar can be controlled with a computer keyboard, smartphone or virtual reality headsets. Text chat, voice and video is ever-present and used to communicate with others in the VRoom. For important meetings and presentations, users can also import audio, video, 2D art and images, animated 3D objects, PDF files and their favorite NFTs by simply dragging and dropping files into a VRoom or pasting a video link from supported media platforms.

Organizations that have an existing website can transition their digital assets, including text, images, video, PDFs, slideshows and more, to VRoom environments with a simple copy and paste. This will allow their customers and audiences to experience their brand in a whole new, immersive environment.
Utopia VR’s mobile app enables users to personalize their own 3D environments and then schedule business meetings or social meetups in seconds through a proprietary link management system. The app is available for iPhone and iPad users. The company’s website mirrors the app, which means users can access Utopia VR directly from a PC, laptop, tablet, or VR headset without downloading the app.

Market Outlook

Regarded as the next iteration of the internet, the metaverse is a virtual space where the physical and digital worlds coexist and interact, encompassing virtual reality, augmented reality, extended reality and mixed reality, as well as making use of artificial intelligence and other technologies.

Data consolidator Statista estimated that the global metaverse market size stood at $38.85 billion in 2021 and projected the market would grow to be worth $47.48 billion in 2022. From there, Statista forecasts the value of the metaverse market will explode to reach $678.8 billion by 2030, achieving a CAGR of more than 39% over the period.

The metaverse could create $5 trillion in opportunity by 2030, according to McKinsey & Company.

Management Team

Stuart Gray, President, Co-Founder and director of Utopia VR, has been an officer and director for both private and publicly traded companies and has led public offerings for junior listed companies that have gone on to realize multibillion-dollar market valuations. He previously was a consultant and quarterbacked taking eXp World Holdings Inc. (NASDAQ: EXPI) public. eXp is a disruptive, no bricks and mortar, real estate brokerage firm with 85,000 agents worldwide using its virtual, software-based, metaverse platform for closing transactions, training and events.

Cory Braden, CTO and director of Utopia VR, is a forward-thinking strategic leader with over 20 years of experience in delivering software as a service. Recognized for a positive leadership style and excellent communication skills, he is well-versed in user experience, complex application architectures, cloud infrastructure and management of high-performance teams.

Terry Woloszyn, VP of Sales and Advisory at Utopia VR, brings vast technical and sales experience to the company. Before joining Utopia VR, he conceived and launched a data security startup and graduated from two startup accelerator programs. He has worked with several successful tech startups throughout his career, from conception to exit.

For more information, visit the company’s website at www.UtopiaVR.com.

NOTE TO INVESTORS: The latest news and updates relating to Utopia VR are available in the company’s newsroom at https://nnw.fm/Utopia https://ibn.fm/Utopia 

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• The company announced partnering with the California Cotton & Climate Coalition (“C4”), working with other like-minded companies to evolve the state’s cotton-growing industry, and build capacity within all stakeholders to grow, source, and develop climate-beneficial, farm-forward textiles
• C4 includes Coyuchi, Mate, Outerknown, Reformation, Trace, Circular Systems, Imperial Yarn, Carhartt, Natural Fiber Welding, Laguna Enviro Fabrics, and opportunities for other companies to join the coalition
• Efforts from Coyuchi’s successful Regulation A+ capital raising is already helping the company grow leadership in the market through expanded marketing, product category expansion, continued physical presence, and B2B strategic partnerships with wholesalers and online marketplaces
• Coyuchi has now opened a second retail location in the Palo Alto Town & Country Village

Coyuchi, the gold standard in sustainable luxury home goods using 100% organic cotton material in its textiles, recently announced the company’s highlights for 2022, including updates on its Regulation A+ offering for investors and operation expansion to better serve its environmentally conscious consumer base. In August, Coyuchi announced its first public offering under Regulation A+ authorization, gaining the company exemption from registration for public offerings under two available tiers as dictated by investment regulations. This round of funding will be used to grow Coyuchi’s leadership in the market through expanded marketing, product category expansion, continued physical presence, and B2B strategic partnerships with wholesalers and online marketplaces. The company has now exceeded $1 million in capital raising, with the unique investment opportunity handled by Manhattan Street Capital. Funds raised during the beginning of the Regulation A+ offering have allowed Coyuchi to open a second retail location in the Palo Alto Town & Country Village. More information on investing with Coyuchi can be found on the Manhattan Street Capital site (https://ibn.fm/PKrjj). During the Regulation A+ announcement, Coyuchi CEO and President Eileen Mockus said it was smart to invest in companies that not only drive financial performance but also focus on positive environmental and social impacts in the communities they serve. “Everyone should have access to this type of investment, which is why we’re excited to launch this Regulation A+ offering. With this public investment, we see an incredible chance to provide greater access to living sustainably for a healthier population and world,” Mockus added (https://ibn.fm/tRwBS). Furthering the company’s mission to protect the planet, innovate circular design, live sustainably, and enrich the community – Coyuchi announced partnering with the California Cotton & Climate Coalition (“C4”), working with other like-minded companies to evolve the state’s cotton-growing industry to grow, source, and develop climate-beneficial, farm-forward textiles. Involved in the coalition are Coyuchi, Mate, Outerknown, Reformation, Trace, Circular Systems, Imperial Yarn, Carhartt, Natural Fiber Welding, Laguna Enviro Fabrics, and opportunities for other companies to join. These companies are a vital part of the coalition’s ecosystem, including farms and farmers, companies purchasing cotton, the coalition team, technical service providers and scientists, and textile development partners (https://ibn.fm/TRey0). Over the last two years, Coyuchi has seen its net income soar, including notable highlights, including $33.3 million in net sales during 2021, 26% year-over-year net sales growth (five times above the industry average of 5%), and 200,000 active customers at a 35% repeat purchase rate. These 2021 highlights are foundational in Coyuchi’s 2022 growth and the company’s expected growth – to be further facilitated by the company’s Regulation A+ authorization and expansion into additional retail space to serve its consumers. For more information, visit the company’s website at www.Coyuchi.com. NOTE TO INVESTORS: The latest news and updates relating to Coyuchi are available in the company’s newsroom at https://ibn.fm/COYU

• Believed to be the first natural low-doses of THC-based compound to enter human trials for Alzheimer’s
• IGC-AD1 has the potential to revolutionize the treatment of Alzheimer’s disease
• The clinical trial is expected to produce data to “help us to further understand the metabolism of IGC-AD1 for a diverse population,” says CEO

In a historic first, India Globalization Capital (NYSE American: IGC) has begun Phase 2 clinical trials evaluating its flagship drug candidate, IGC-AD1, for the treatment of agitation in dementia from Alzheimer’s disease (https://nnw.fm/Y1rLN). (https://cnw.fm/LGAZG). (https://ibn.fm/fg4A3). Company officials noted that, to their knowledge, this is the first natural low-dose THC-based compound to enter human trials for the treatment of symptoms such as agitation in dementia from Alzheimer’s disease. Currently there is no FDA-approved medication to treat agitation in Alzheimer’s.

“We believe IGC-AD1 has the potential to revolutionize the treatment of the symptoms (agitation) of Alzheimer’s disease as the only natural low-dose THC-based formulation candidate currently undergoing FDA testing,” said IGC CEO Ram Mukunda. “Approximately 8 million people are affected by Alzheimer’s in North America and over 55 million worldwide. We believe that the diverse population we have selected for this study will allow us to accurately look at both the impact of variations of the gene CYP2C9 that metabolizes THC, as well as the APOE e4 a gene that increases the risk of developing Alzheimer’s.

“This data will help us to further understand the metabolism of IGC-AD1 for a diverse population, which is important in a disease that has a global impact like Alzheimer’s,” Mukunda continued. “Through these and further trials, we look forward to establishing IGC-AD1’s efficacy in treating the symptoms related to Alzheimer’s disease.”

IGC’s Phase 2 trial, a multicenter, double-blind, randomized, placebo-controlled study of IGC-AD1, has started at two sites in the United States, with plans to add up to five additional sites throughout the U.S. and Canada; a site in South America is also being considered in order to increase population diversity and promote the inclusion of underrepresented populations.

According to the company, the trial will enroll 146 patients with one-half of participants, the “treated” group, receiving IGC-AD1, and the other half, the “control” group, receiving a placebo. “The goal of the trial is to evaluate and establish the efficacy of IGC-AD1 in helping patients with Alzheimer’s dementia reduce neuropsychiatric symptoms (‘NPS’) such as agitation, which effects 76% of individuals with Alzheimer’s,” the announcement stated. “Currently, there is no Food and Drug Administration (‘FDA’)-approved drug for treating agitation in dementia due to Alzheimer’s.”

According to the announcement, IGC-AD1 relies on low-doses of THC, a psychoactive cannabinoid, and another compound as active agents. In the pre-clinical trials, the formulation demonstrated in Alzheimer’s cell lines the potential to be effective in suppressing or ameliorating a key protein that is responsible for Aβ plaques, a key hallmark of the disease.

India Globalization Capital develops advanced cannabinoid-based formulations for treating diseases, including but not limited to Alzheimer’s disease, Parkinson’s disease, chronic pain, and even pet seizures. The company sells various brands of CBD-based consumer products, including Holief, which includes gummies and pain relief creams for women experiencing premenstrual syndrome and dysmenorrhea (period cramps), and Sunday Seltzer, which includes a CBD-infused energy beverage. The company operates facilities in the United States under Good Manufacturing Practices.

For more information, visit the company’s website at www.IGCPharma.com.

NOTE TO INVESTORS: The latest news and updates relating to IGC are available in the company’s newsroom at https://nnw.fm/IGC https://ibn.fm/IGC https://cnw.fm/IGC

• RNG is produced by decomposing and processing organic matter into compressed natural gas (“CNG”) to power vehicles, liquefied natural gas (“LNG”) for residential, commercial, and industrial uses
• RNG is completely compatible and fully interchangeable with conventional natural gas within existing pipeline networks
• EVGIF acquires, develops, builds, and owns a portfolio of RNG waste-to-energy and related infrastructure projects in British Columbia, Alberta, and Ontario

EverGen Infrastructure’s (TSX.V: EVGN) (OTCQX: EVGIF) renewable natural gas (“RNG”) infrastructure platform is tapping into the power of organic waste to power homes and vehicles across Canada. Starting in British Columbia on the west coast and Ontario towards the east, the company acquires, develops, builds, owns, and operates a portfolio of RNG waste-to-energy and related infrastructure projects with the aim of lowering greenhouse gases and powering a sustainable future. Converting organic waste into usable energy is not a new concept. The United States Clean Water Act of 1972 mandated the extraction of energy from methane – a colorless, odorless natural gas produced by certain human activities – before it was burned (https://ibn.fm/coCrr). As a result, hundreds of facilities across California currently produce electricity from a biogas-fueled engine. EVGIF is dedicated to making similar technological advances in Canada. RNG is a high-quality, completely compatible gas alternative that is fully interchangeable with conventional natural gas within the existing pipeline network. It is produced by decomposing and processing organic matter into compressed natural gas (“CNG”) to power vehicles or liquefied natural gas (“LNG”) that can be used for residential, commercial, and industrial purposes. EverGen aims to bring RNG technology to Canadian homes and businesses by building an infrastructure network of over 20 facilities within five years. The company’s current footprint comprises five RNG and/or organic processing facilities that include Net Zero Waste Abbottsford, Fraser Valley Biogas, and Sea to Sky Soils in British Columbia. Towards the east, the company has a 67% ownership in Alberta-based GrowTEC and a 50% stake in Ontario-based Project Radius. RNG produced at Net Zero Waste Abbottsford, Fraser Valley Biogas, and GrowTEC is bought via long-term offtake agreements by FortisBC – the largest natural gas distributor in British Columbia. With a focus on the East, EVGIF recently acquired a 50 percent interest in Project Radius – a portfolio of RNG development projects in Ontario that can collectively produce approximately 1.7 million RNG GJ/year. “When you add it all together, we’ve got a business capable of delivering $30 million of EBITDA from the portfolio that we have in front of us, and we see 25+ projects in Canada that could deliver 4x growth beyond that”, said EVGIF CEO Chase Edgelow in a recent interview on The Bell2Bell Podcast (https://ibn.fm/jmDCF). “There’s a tremendous amount of opportunity in this space right now.” Based in Vancouver, British Columbia, EverGen is an established independent RNG producer committed to developing Canada’s RNG infrastructure. With projects across the country, the company is emerging as a leader committed to powering a sustainable, net-zero future based on sustainable energy sources. For more information, visit the company’s website at www.EverGenInfra.com. NOTE TO INVESTORS: The latest news and updates relating to EVGIF are available in the company’s newsroom at https://ibn.fm/EVGIF

• BiondVax is developing a pipeline of nanosized antibody (“NanoAb”) therapies addressing diseases with large underserved medical needs and attractive commercial opportunities
• BiondVax recently announced results from a preclinical in vivo proof-of-concept study indicating its innovative inhaled NanoAb COVID-19 therapy virtually eliminates viral presence in the lungs and leads to significantly shorter and milder illness
• BiondVax CEO Amir Reichman presented at the Biotech Showcase Conference, where he discussed recent successful results from the preclinical in vivo study, additional pipeline plans for other NanoAb therapeutics, and the company’s derisked R&D strategy

Mainland China is experiencing a fresh wave of COVID-19 infections sweeping some of its most populous provinces. The SARS-CoV-2 virus, which causes COVID-19, has been spreading fast since the Chinese government in early December lifted restrictions that were aimed at containing infections (https://ibn.fm/SzDKu).

Results of the policy have been dire. Early this year, officials reported the Omicron variant had already infected 89% of the Henan province’s 100 million residents. This comes after late December reports that the industrial province of Zhejiang was battling around 1 million new daily COVID-19 infections, a number that was expected to double in the days ahead (https://ibn.fm/oPJGX). “High levels of SARS-CoV-2 infections and increased pressure on healthcare services in China are expected in the coming weeks due to low population immunity and the relaxation of non-pharmaceutical intervention,” stated a January 3 article by the European Center for Disease Prevention and Control (“ECDC”) (https://ibn.fm/O1JfL).

For Amir Reichman, the CEO of biotechnology company BiondVax Pharmaceuticals (NASDAQ: BVXV), the ongoing outbreak in China and frequent emerging variants have reinforced an undeniable fact: “that continuous development of innovative and safe therapeutics for COVID-19 is the most effective and economical way to control this disease.” Coupled with the fact that there uptake of COVID-19 vaccinations and boosters is waning, there is a significant unmet need that BiondVax intends to solve with its inhaled nanosized antibody (“NanoAb”) COVID-19 therapy.

Developed as part of a strategic research collaboration with the Max Planck Institute for Multidisciplinary Sciences and the University Medical Center Göttingen, the alpaca-derived NanoAb therapies are designed to address diseases with large underserved medical needs and attractive commercial opportunities, including COVID-19, asthma, psoriasis, psoriatic arthritis, and other large market disorders. As part of the development process, BiondVax is conducting a preclinical in vivo proof-of-concept study of its inhaled NanoAb COVID-19 therapy, with the results expected to inform the design of the first-in-human clinical trial of the inhaled COVID-19 therapeutic planned for Q4 2023.

In a recent news release announcing the latest results from the preclinical study, BiondVax reported that the presence of the SARS-CoV-2 virus in the lungs of hamsters treated with the inhaled NanoAb was below detectable levels and significantly (p<0.0005) less than the amount of virus detected in the control group. The study showed that six days after infection, hamsters treated with the inhaled NanoAb had over 30x lower SARS-CoV-2 viral titers in their lungs than the placebo group as measured by median tissue culture infectious dose (TCID50). This highly significant data suggests that BiondVax’s NanoAbs may have the breakthrough potential to dramatically reduce the risk of transmission. According to the announcement, these results were corroborated by PCR testing (https://ibn.fm/KLXl4).

“These lung viral titer results indicate that our inhaled NanoAbs essentially eliminated viral presence in the lungs and led to a shorter and milder illness,” commented Dr. Tamar Ben-Yedidia, BiondVax’s Chief Science Officer (“CSO”). “This data is unequivocal and exciting. We’re looking forward to continuing this study this month by testing additional dose levels of the inhaled NanoAb therapy and as a prophylactic (preventive) treatment.”

The most recent announcement builds on results from the same study reported November 29, 2022. These earlier results showed that the control group’s weight post-infection declined by 12.01% on average compared to the pre-infection weight. In contrast, the weight of hamsters that received the inhaled NanoAb therapeutic declined by only 3.80% on average, a highly statistically significant result (p<0.001) (https://ibn.fm/93ykQ). Weight loss in hamsters is a commonly accepted indicator of COVID illness severity, and was also used as a proxy in earlier studies for Regeneron’s (NASDAQ: REGN) REGEN‑COV COVID antibody cocktail treatment and Pfizer’s (NYSE: PFE) blockbuster COVID treatment Paxlovid.

According to BiondVax, the preclinical study is set to continue in January 2023 and will test lower therapeutic doses and a prophylactic dose of the NanoAb, in addition to evaluating safety parameters. Moreover, the company will this year also conduct a preclinical toxicity study to evaluate safety. BiondVax also intends to scale up its manufacturing processes to produce the NanoAbs in their in-house GMP facility in preparation for the planned Q4 2023 first-in-human Phase 1/2a clinical trial.

Meanwhile, Mr. Reichman recently presented at the Biotech Showcase Conference held between January 9-11, 2023. The presentation focused on the recent successful preclinical in vivo trial results, additional pipeline plans for the other NanoAb therapeutics, and BiondVax’s derisked R&D strategy (https://ibn.fm/HDady).

BiondVax is focused on developing, manufacturing, and commercializing innovative large market immunotherapeutic products primarily for the treatment of infectious and autoimmune diseases.

For more information, visit the company’s website at www.BiondVax.com.

NOTE TO INVESTORS: The latest news and updates relating to BVXV are available in the company’s newsroom at https://ibn.fm/BVXV

• Eloro Resources’ CEO, Thomas Larsen recently attended the Mines and Money London conference as a featured speaker during the event.
• As part of the forum, Larsen participated in a one-on-one interview with Commodity-TV, during which he elaborated on the prospects of the company’s Bolivian silver – tin polymetallic project, Iska Iska
• With initial exploratory drilling analysis taking place on the site since September of 2020, Larsen expressed his optimism on the resource metal concentration within the Iska Iska project
• Eloro will look to publish its inaugural resource estimation by March 2023 prepared by Micon International

Eloro Resources Ltd. (TSX.V: ELO) (OTCQX: ELRRF) (FSE: P2QM), an exploration and mine development company focused solely on its key Bolivian property, ISKA ISKA, was a featured presenter at the recent Mines and Money London conference. Held between Nov. 29 – Dec. 1, 2022, the Mines and Money London forum has emerged as Europe’s largest and most in-depth mining conference dedicated towards touting the global sustainability agenda. With a focus on energy transition, ESG, decarbonisation and the circular economy, the production of tin, zinc and silver – crucial ingredients needed to fuel the ongoing green energy transition, has gained particular relevance in years. As part of the conference agenda, this year’s event played host to an in-depth interview carried out by Commodity-TV featuring Eloro Resources CEO, Thomas Larsen (https://ibn.fm/RDMFs). Iska Iska is located in the prolific Potosi region of Southern Bolivia, an area renowned for its world-class silver and tin deposits. ISKA ISKA is located a mere 180 kilometers south of the Cerro Rico deposit, which is widely acknowledged as one the world’s most prolific silver deposits having produced over 2.5 billion silver ounces since the sixteenth century and still producing today. Having optioned the deposit from the tract’s owners in January 2020, Eloro agreed to pay a gross consideration amounting to $10 million to the title holder by 2024 to acquire a 100% interest in the project. With just under half of the figure already disbursed, Eloro will seek to make the balance payment of $5.6 million at or before June 2024. Eloro commenced the inaugural drill program at the Iska Iska site in Sept. 2020 and since then, has drilled over 120 holes and 85,000 meters within the property. These initial discoveries in late 2020 convinced the company of the site’s relative potential. Between Nov. 2020 and Jan. 2021, the company found that its initial holes – most of which were between 250 and 300 meters in length, were delivering bulk tonnage of 150 silver grams equivalent per ton – a level of silver concentration which has been found to be economically viable in the past. Larsen further revealed that Eloro Resources was acquiring the Mina Casiterita and Mina Hoyada properties, that adjoin the existing Iska Iska deposit towards the property’s western and south-western boundaries. These two properties have the same mineral characteristics as that of ISKA ISKA, allowing a potential extension of the overall deposit, but just as importantly, easier access to the potential tin deposit below.  Larsen explained that artisanal mining in the 1960’s had revealed the Mina Casiterita property to contain significant amounts of tin.  As such, it came as little surprise when Larsen stated during the interview that geophysical data now suggested that the high-grade feeder zone could be extended for another 500 metres to 2,000 metres, which the final drill holes had initially tested in the 2022 program.” Following the purchase and post the near-term conclusion of exploratory drilling within the Iska Iska deposit, the company has now set their sights on the continuation of exploring this sizable deposit and the completion of the inaugural resource b by March 2023, a development which could mark the next step in Eloro Resources’ commercial journey. For more information, visit the company’s website at www.EloroResources.com. NOTE TO INVESTORS: The latest news and updates relating to ELRRF are available in the company’s newsroom at https://ibn.fm/ELRRF