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Platinum Group Metals Ltd. (NYSE American: PLG) (TSX: PTM) Is ‘One to Watch’

  • Operator of flagship Waterberg PGM Project located in South Africa, which is home to 70% of platinum and 35% of palladium global mine production in 2023
  • Over $89M invested to date in exploration and feasibility engineering since initial discovery in 2011
  • The Waterberg Project has proven and estimated reserves of 19.5 million ounces of PGMs and gold with a projected production life of 45 years
  • Partnered with major integrated PGM producer Impala Platinum Holdings Ltd. and Japanese consortium HJ Platinum, which includes trading house Hanwa Co. and the government-backed Japan Organization for Metals and Energy Security
  • A 2019 Definitive Feasibility Study (“DFS”) confirmed Waterberg as one of the largest and lowest cost undeveloped PGM projects globally
  • In December 2023, entered an agreement with Ajlan & Bros Mining and Metals to study establishment of a PGM smelter and base metals refinery in Saudi Arabia
  • PGM market dynamics are favorable based on growing demand from gasoline hybrid and plug-in hybrid (“PHEV”) technology adoption and expected supply cutbacks from major producers in Southern Africa, North America and Russia
  • An update to the 2019 Waterberg Definitive Feasibility Study is expected in 2024
  • Founded Lion Battery Technologies Inc. in partnership with Anglo American Platinum Ltd. (AMS: JSE) to research and commercialize the use of PGMs in lithium-sulfur battery chemistry

Platinum Group Metals (NYSE American: PLG) (TSX: PTM) is the operator of the Waterberg Project, a bulk underground platinum group metals (“PGM”) deposit discovered by Platinum Group in 2011 and located on the Northern Limb of the Bushveld Complex in South Africa. The Waterberg Project is planned as a fully mechanized platinum, palladium, rhodium and gold mine, including by-product copper and nickel production, and is projected to be one of the largest and lowest cost PGM mines globally.

The project is a joint venture between Platinum Group; integrated PGM producer Impala Platinum Holdings Ltd. (OTCQX: IMPUY); Japanese consortium HJ Platinum, which includes trading house Hanwa Co. and the government-backed Japan Organization for Metals and Energy Security (“JOGMEC”); and local empowerment partner Mnombo Wethu Consultants (Pty) Ltd. Platinum Group has an effective 50.22% interest in the Waterberg Project.

The company’s primary business objective is to advance the Waterberg Project to a development and construction decision. An update to the 2019 Definite Feasibility Study is expected in 2024.

PGMs are essential and precious metals that include platinum, palladium, rhodium, iridium, osmium and ruthenium. These metals are known for their purity, high melting points and unique catalytic properties. They are utilized in a number of industrial processes, technologies and commercial applications and play a critical role in autocatalysis and pollution control in the automotive sector. The bulk of global PGMs are mined in Southern Africa and Russia.

The unique properties of PGMs are being applied to various technologies as possible solutions for more efficient energy generation and storage, which may create new demand for PGMs. The company’s battery technology initiative through Lion Battery Technologies Inc., using platinum and palladium in lithium battery technologies, represents one such new opportunity in the high-profile lithium battery research and innovation field.

Platinum Group Metals Ltd. founded Lion Battery Technologies Inc. in partnership with Anglo American Platinum Ltd. (AMS: JNB) to support the use of palladium and platinum in lithium battery applications. Lion Battery has entered into an agreement with Florida International University to further advance a research program that uses platinum and palladium to unlock the potential of Lithium Sulfur (“Li-S”) battery chemistries.

Platinum Group is headquartered in Vancouver, B.C., and Johannesburg, South Africa.

Waterberg Project

Platinum Group’s sole material mineral property, the Waterberg Project, is presently in process with pre-construction permitting; engineering work, including road upgrade and traffic studies; finalization of power and water infrastructure design; and construction camp design.

The company’s principal product from the Waterberg Project is planned to be a PGM-bearing concentrate. The concentrate will contain economic amounts of six elements comprising platinum, palladium, rhodium, gold, copper and nickel. The company’s partner in the Waterberg Project, Impala Platinum Holdings, has acquired a right of first refusal to enter into an offtake agreement, on commercial arm’s-length terms, for the smelting and refining of mineral products from the Waterberg Project.

The Waterberg project has proven and estimated reserves of 19.5 million ounces of PGMs and gold. When fully operational, the mine is projected to produce more than 400,000 ounces of PGMs annually during the peak period of steady state production. The life of the mine is projected at 45 years.

South Africa’s PGM mining sector remains closely tied to economic developments in the global automotive industry, which in 2022 accounted for approximately 43% of the total global demand for platinum and 82% of the total global demand for palladium.

Market Opportunity

According to a report from Straits Research, a global market and business research firm, the worldwide platinum market had an estimated value of $7.72 billion in 2022 and is projected to reach $11.95 billion by 2031. That represents a CAGR of 5.13% over the forecast period.

Platinum, one of the rarest of precious metals, is about 30 times scarcer than gold. It is crucial to the automotive and electronics industries and is also used to make jewelry. Stricter emissions regulations around the world have led to an increased demand for platinum to be used in catalytic converters to reduce automotive emission, the report states.

A report from Allied Market Research estimated the global palladium market at $16.3 billion in 2021 and projects the market will reach $28.6 billion by 2031, growing at a CAGR of 5.8% over the period.

Palladium is also used in automotive catalytic converters for reducing emissions and in jewelry, dentistry, watchmaking, blood sugar test strips, aircraft spark plugs, surgical instruments, electrical contacts and musical instruments.

An increase in demand for consumer electronics has driven demand for palladium-based multilayer ceramic capacitors (“MLCC”) used to store energy in electronic devices such as broadcasting equipment, mobile telephones, computers, electronic lighting and high voltage circuits, according to the report.

Management Team

Frank R. Hallam is Co-Founder, Director, President and CEO of Platinum Group. He has over 30 years of experience in the mining, minerals and petroleum industry as an operator, principal and founder. He was a co-founder and former CFO of MAG Silver Corp. He was also co-founder and director of West Timmins Mining Inc. and a director of Lake Shore Gold Corp. In addition, he was CFO and director with gold exploration company Tan Range Exploration Corp. He is a Chartered Professional Accountant and was formerly an auditor in the public mining practice of PwC. He holds a Bachelor of Business Administration from Simon Fraser University.

Greg Blair is CFO of Platinum Group. He has been with Platinum Group since 2010 in various roles, most recently as Interim CFO. Prior to joining Platinum Group, he was at a public accounting firm working on public company (mainly mining) audits. He is a Chartered Professional Accountant and holds a degree in Economics from Simon Fraser University and has completed the Canadian Securities Course.

Kris Begic is VP Corporate Development of Platinum Group. He has over 25 years of experience in the mining industry and capital markets and has been involved with the raising of over $500 million for various exploration and development projects globally. His efforts are focused on project generation, mergers and acquisitions, capital markets, investor relations and marketing.

For more information, visit the company’s website at www.PlatinumGroupMetals.net.

NOTE TO INVESTORS: The latest news and updates relating to PLG are available in the company’s newsroom at https://ibn.fm/PLG

Lexaria Bioscience Corp. (NASDAQ: LEXX) Targeting Oral GLP-1 Alternatives for Diabetes and Obesity Treatment

  • Lexaria, a global innovator in drug delivery platforms, is exploring its patented DehydraTECH(TM) technology for the oral delivery of glucagon-like peptide-1 (“GLP-1”) drugs.
  • GLP-1 drugs have shown great promise in addressing diabetes and obesity, with nearly all the major brands administered only through injection devices.
  • A previous human study by Lexaria evidenced improved bioavailability when semaglutide was administered orally, as compared to standard Rybelsus®.
  • Lexaria has several additional R&D studies underway, including both animal and human investigations into semaglutide, liraglutide and tirzepatide. Together, those three drugs represent more than 90% of all revenue in the current global GLP1 market.

Data from the United States shows that 54% of adults and 66% of children consume more added sugars than recommended (https://ibn.fm/W2oXd). On average, it has been noted that adults, young adults, and children in the United States consume 17 teaspoons of added sugar daily, which is more than two to three times the recommended amount for men and women, respectively. Extrapolated annually, this adds up to around 60 pounds of added sugar or six 10-pound bowling balls (https://ibn.fm/Dah7s).

Numerous studies have linked increased sugar consumption to diabetes. While not directly linked, sugar is considered integral to weight gains, which, in turn, increases their risk of type 2 diabetes. The condition cannot be cured, but it can be managed. Recent studies on glucagon-like peptide-1 (“GLP-1”) have shown great promise in addressing the condition. Lexaria Bioscience (NASDAQ: LEXX), a global innovator in drug delivery platforms, recognizes the potential of these GLP-1 drugs, and if any of its recent studies are anything to go by, the company is on track to offer an oral delivery enhancement to current GLP-1 options that are in the market today.

People living with diabetes often require insulin shots to manage their condition. Although many types of insulin are available, including long-acting, rapid-acting, and short-acting, none of those can be taken orally to lower blood sugar. This is because stomach enzymes have been shown to interfere with insulin’s action, prompting the use of needles and syringes, or an insulin pen, to deliver the product to the body (https://ibn.fm/5LCz7). This has also been the case for GLP-1 drugs.

“Most GLP-1 drugs sold today are administered by painful and expensive injection devices. More effective and tolerable oral delivery of GLP-1 could be extremely valuable to patients and to industry,” noted Chris Bunka, Lexaria’s CEO (https://ibn.fm/RxUBh).

Lexaria has explored oral delivery of GLP-1 drugs using its patented DehydraTECH(TM) technology since the beginning of the year. So far, its studies have evidenced increased bioavailability, with its WEIGHT-A24-1 diabetes animal study showing a stark decrease in the rate of body weight gain for specific DehydraTECH-CBD formulations and noticeable weight loss for its DehydraTECH-Liraglutide (https://ibn.fm/iB9NN). All of its studies thus far have highlighted DehydraTECH’s potential in treating diabetes and obesity, and the company looks to double down on this research for the remainder of the year.

As the conversation about added sugars, diabetes, and obesity proliferates, the company’s management is optimistic about its ongoing GLP-1 studies. It is also confident that the studies will yield positive results, demonstrating the superiority of DehydraTECH as a drug delivery technology. As a company, Lexaria has already validated the technology’s usefulness in delivering various orally administered bioactive molecules more effectively. Its focus on GLP-1 drugs for the potential treatment of diabetes and obesity speaks to the company’s confidence in the technology and its commitment to stamping its position as a leader in the market.

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://ibn.fm/LEXX

D-Wave Quantum Inc. (NYSE: QBTS) Expands Product Roadmap to Bring Power of Quantum to Artificial Intelligence & Machine Learning

  • Expanded product roadmap to enhance D-Wave’s Leap(TM) quantum cloud service and bring new Quantum AI solutions to market
  • Initiative targets three key development areas: quantum distributions for generative AI, Restricted Boltzmann Machine (“RBM”) architectures, and GPU integration
  • CEO Dr. Alan Baratz emphasizes the potential of annealing quantum computing to transform AI/ML by offering more efficient model training, reduced energy consumption, and faster time-to-solution 

D-Wave Quantum (NYSE: QBTS), a leader in quantum computing systems, software and services, and the first commercial provider of quantum computers, has announced a significant expansion of its Leap quantum cloud service, targeting advancements in artificial intelligence (“AI”) and machine learning (“ML”). The newly revealed roadmap outlines strategic initiatives aimed at integrating quantum computing with AI/ML technologies to offer more efficient and powerful computational capabilities (https://ibn.fm/oZpfR).

The product roadmap is designed to support customers in addressing various AI/ML workloads, from pre-training optimization to more accurate model training and new AI business use cases that integrate artificial intelligence and business optimization. The roadmap focuses on three pivotal development areas:

  • Quantum distributions for generative AI: The focus in this area is on designing novel, modern generative AI architectures that directly use quantum processing unit (“QPU”) samples from quantum distributions that cannot be generated by classical computers. 
  • Restricted Boltzmann Machine (“RBM”) architectures: RBM architectures that directly leverage D-Wave’s QPU for various applications are increasingly being used by customers, potentially leading to reduced energy consumption in training and running AI models. 
  • GPU integration with Leap Quantum Cloud Service: D-Wave is incorporating additional graphics processing unit resources in the Leap quantum cloud service for the training and support of AI models, while also working to reduce latency between QPUs and classical computing resources, a critical step in enabling hybrid-quantum technology for AI/ML.

The initiative comes at a time when the AI industry is facing an energy crunch, given the high energy usage and associated costs necessary to satisfy a growing set of use cases. Current AI models, especially large language models (“LLMs”), require extensive amounts of power to train and run. At current rates of growth, AI is expected to account for up to 3.5% of global electricity demand by 2030 (https://ibn.fm/lUbDP).

D-Wave’s Quantum AI solutions have the potential to change that given annealing quantum computing’s unique capability to solve optimization issues and help customers leverage better, faster and more energy efficient AI and ML workloads.

Dr. Alan Baratz, CEO of D-Wave, highlighted the transformative potential of this roadmap, underlining that the company is already seeing early evidence that annealing quantum computing could play a key role in helping AI/ML with more efficient model training, reduced energy consumption and faster time-to-solution.

“With results demonstrating our annealing quantum computer’s ability to outperform classical techniques, coupled with rapidly increasing demand from our customers for Quantum AI solutions that integrate with their business optimization requirements, we believe the impact of D-Wave’s Quantum AI solutions could be transformative, bringing a powerful new set of new computing tools for generative AI,” Dr. Baratz said.

For more information, visit the company’s website at www.DWaveQuantum.com.

NOTE TO INVESTORS: The latest news and updates relating to QBTS are available in the company’s newsroom at https://ibn.fm/QBTS

Forward-Looking Statements

Certain statements in this press release are forward-looking, as defined in the Private Securities Litigation Reform Act of 1995. These statements involve risks, uncertainties, and other factors that may cause actual results to differ materially from the information expressed or implied by these forward-looking statements and may not be indicative of future results. These forward-looking statements are subject to a number of risks and uncertainties, including, among others, various factors beyond management’s control, including the risks set forth under the heading “Risk Factors” discussed under the caption “Item 1A. Risk Factors” in Part I of the company’s most recent Annual Report on Form 10-K or any updates discussed under the caption “Item 1A. Risk Factors” in Part II of the company’s Quarterly Reports on Form 10-Q and in the company’s other filings with the SEC. Undue reliance should not be placed on the forward-looking statements in this press release in making an investment decision, which are based on information available to the company on the date hereof. The company undertakes no duty to update this information unless required by law.

Nightfood Holdings Inc. (NGTF): The Power of Portfolio Diversification

  • Nightfood is blowing up TikTok with its sleep-friendly cookies for nighttime snackers
  • 2024 has been a transformational year, as Nightfood Holdings diversifies into new markets, including Robots-as-a-service (“RaaS”)
  • Nightfood has acquired Future Hospitality Ventures, providing cutting edge technologies for the hospitality and foodservice industry, and signed a Letter of Intent to acquire CarryOutSupplies.com, a packaging distribution company with sales on the rise after $2 million in 2023

Nightfood Holdings (OTCQB: NGTF) has come a long way since its initial focus on the nighttime snacking market. Recent developments reveal a company actively pursuing diversification and expansion into new and emerging sectors. In addition to their sleep-friendly cookies for nighttime snackers, Nightfood is demonstrating building value by exploring disruptive technologies and capturing new markets.

A Foundation in Sleep-Friendly Snacks

Nightfood’s journey began with a simple yet compelling premise: address the growing nighttime snacking epidemic. The company’s flagship products – a line of sleep-friendly cookies – are formulated to minimize sleep disruption caused by unhealthy nighttime snacking, and nutritionally support sleep quality. This unique offering is aimed at the 93% of American adults who snack before bed at least once a week (the average American adult snacks 3.9 nights per week, resulting in over 1 billion nighttime snacks consumed weekly). The cookies are blowing-up TikTok. Nightfood’s pioneering of this potentially massive snacking sub-category will continue to be a core asset.

Disrupting Hospitality with Robots as a Service (“RaaS”)

Nightfood isn’t content with simply offering snacks. Recent announcements highlight the company’s acquisition of Future Hospitality Ventures, a provider of automation and robotics technology for the hospitality and foodservice industry. Management is understandably keeping the details of the new tech close to the vest, but press releases suggest a focus on improving operational efficiency and addressing labor cost and shortage. This foray into robotics and AI signifies Nightfood’s ambition to become a solutions provider within the hospitality space, moving beyond just a snack supplier.

The company has dropped hints that more information will be forthcoming based upon comments that meetings with management across an array of industries from hotels to restaurants is creating a stir for additional discussions.

CarryOutSupplies.com Acquisition Broadens Horizons

Perhaps the most exciting development is Nightfood’s recent entry into a letter of intent to acquire CarryOutSupplies.com in an all-stock transaction. CarryOut is an established provider of disposable and eco-friendly supplies to restaurants and foodservice establishments, offering a wide range of takeout supplies. This acquisition indicates Nightfood’s desire to build a comprehensive ecosystem within the food service industry.

It also serves to jump-start revenue. CarryOutSupplies.com had a thriving business before the covid pandemic dampened sales. Business is recovering, with sales topping $2 million in 2023, presenting a well-timed opportunity for Nightfood to pull the company under its umbrella.

Diversification: A Calculated Gamble

Can a small holding company effectively and efficiently layer in multiple operating companies to drive investor value?  The timing certainly seems right for each individual subsidiary: Nightfood has reported initial success from the online launch of their sleep-friendly cookies;  Future Hospitality is launching into a very receptive market as California restaurants and hospitality are feeling the crush of a massive minimum wage increase that has been making national news; and CarryOutSupplies seems poised to reach pre-pandemic revenue levels which are multiples higher than the $2 million in sales recorded in calendar 2023.

There are several benefits to Nightfood’s diversification strategy. For starters, while pioneering the sleep-friendly snack category, expansion into automation and foodservice supplies offers access to markets that are already established and on a growth trajectory, easing the heavy lifting. Second, Wall Street likes tech, but loves revenue. Nightfood’s diversification creates multiple revenue streams, and instantly adds millions in revenue with the proposed acquisition of CarryOut. This can provide financial stability and reduce vulnerability to market fluctuations.

Lastly, the potential synergies between the businesses are numerous. For instance, marketing and selling robotic solutions leveraging CarryOutSupplies.com e-commerce, while Nightfood’s ongoing discussions could lead to new distribution channels for its snacks, as well as new sales channels through CarryOutSupplies’ network of customers.

Nightfood’s diversification strategy could certainly deliver strong value to shareholders. While sleep-friendly snacks remain a core product line with potential explosive upside, Nightfood Holdings is evolving into a multifaceted entity with a presence in the hospitality industry, technology, and foodservice. This bold approach, if executed effectively, could deliver exciting growth for investors here in 2024 and beyond.

For more information, visit the company’s website at https://nightfood.com/.

NOTE TO INVESTORS: The latest news and updates relating to NGTF are available in the company’s newsroom at http://ibn.fm/NGTF

Renforth Resources Inc. (CSE: RFR) (OTCQB: RFHRF) Is ‘One to Watch’

  • Renforth Resources Inc. is a mineral exploration company engaged in the acquisition, exploration and development of mineral properties in Canada
  • The company holds gold and battery mineral resources in Quebec’s mining heartland
  • Renforth Resources in July 2024 resumed exploration on its Parbec Gold Deposit, consisting of a surface soil sampling and prospecting campaign
  • The company in July 2024 received a C$262,500 grant from the Province of Quebec to identify and study the metallurgical characteristics of the Victoria mineralization

Renforth Resources (CSE: RFR) (OTCQB: RFHRF) is an active mineral exploration company engaged in the exploration and development of the company’s wholly owned multi-commodity mineral properties in Canada. The company owns the Parbec gold deposit on the Cadillac Break in Quebec and is currently exploring the Parbec property to increase the gold resource and identify a location to strip and bulk sample from surface.

In addition, the company holds the Nixon Bartleman gold property in Ontario and is also engaged in developing its wholly owned Malartic Metals Package, Quebec’s newest polymetallic battery minerals district with several areas of mineralization, one of which is the nickel, cobalt, copper and zinc mineralized Victoria structure boasting approximately 20 kilometers of strike with surface mineralization, limited drilling, road access and hydroelectric power.

Renforth is well positioned in the heart of the Abitibi Greenstone belt, which straddles the Canadian Provinces of Ontario and Quebec, on both of the Cadillac-Larder Lake and Destor-Porcupine faults – the two main structures responsible for a belt endowed with more than 300 million ounces of gold (including production, M&I reserves and resources to date), making it one of the world’s most prospective gold regions.

The Canadian Malartic Mine, one of Canada’s largest gold mines, is adjacent to each of Renforth’s brownfield Malartic area properties, the Parbec open pit gold resource and the Malartic Metals Package, which, in addition to several known battery metals mineralized structures, also hosts gold within the Pontiac sediments, a very under-explored geological setting.

The company is headquartered in Pickering, Ontario.

Projects

Parbec Gold Deposit

Renforth’s 100% owned Parbec Gold Deposit contains a gold resource designed with an open pit to capitalize on Parbec’s surface mineralization. An MRE on the project, effective December 2019 and now considered by Renforth to be obsolete, is based upon approximately 28,000 meters of drilling which occurred between 2007 and 2019.

Renforth drilled 15,000 meters of new holes in 2020 and 2021 which were not included in the MRE, but which did extend the mineralization deeper within the MRE. The 2020-21 drilling is considered to have validated an additional 13,000 meters of historic drilling from 1986-93.

The validation occurs as 10% of the historic holes were redrilled, with results comparable to the historic results in terms of geology and gold values. Any future MRE calculated at Parbec will benefit from the inclusion of the new and historic drilling.

In addition to this, Renforth’s current structural interpretation on the location of, and controls on, the gold mineralization at Parbec is materially different than the geological model for the outdated MRE. For the first time, Renforth has mapped the Pontiac contact and interpreted a hinge fold interacting with the Cadillac Break and allowing the movement of gold enriched fluids, with mineralization plunging to the south, into the Pontiac.

It is worth noting that a structural control on the adjacent, and much larger, Canadian Malartic Mine is the Sladen Fault transiting into the Pontiac. Currently, Renforth is testing this interpretation with a soil survey designed to outline an area for stripping and bulk sampling within the Pontiac south of the Cadillac Break.

Malartic Metals Package

Renforth’s wholly owned approximately 300-square-kilometer Malartic Metals Package in Quebec’s mining heartland includes surface mineralization of battery metals nickel, cobalt, copper, zinc and silver in separate structures, as well as a copper/silver discovery and gold mineralization. Lithium is also present in anomalous amounts in the sediments, though the source has not yet been located.

The property was assembled commencing in 2020 by adding claims to Renforth’s existing Malartic West property by map staking. The goal was to acquire historic gold and base metal showings, as well as pronounced magnetic anomalies, joining several of the areas of discrete historic exploration into a district scale property with several areas of interest for battery metals and a greenfield copper/silver discovery. The property benefits from its location in an established mining community, roads on the property, rail just off the property and hydroelectric power lines crossing the property, making logistics simple and the cost to operate quite low.

This is the first time this property has been assembled as it is today and actively explored. A significant portion of the property has never been explored.

Market Overview

The World Gold Council, the industry association for the world’s gold producers, estimated in 2023 the physical financial gold market, which is made up of bars, coins, gold ETFs and central bank reserves, is worth nearly $5 trillion. The council reports that gold mine production adds approximately 3,500 tons of the precious metal to the world’s supply annually, equivalent to about 2% growth.

This historical scarcity and relatively slow production of new supply, as compared to other commodities, is a primary reason gold has retained its value for millennia, according to the council. In August 2024, the market price of gold was approximately $2,435 per ounce.

Management Team

Nicole Brewster is President and CEO of Renforth Resources. During her tenure she has reconstituted the company, developed a maiden mineral resource and sold a gold deposit. She is a native of the Toronto area and has been around the mining business nearly all her life, having been raised by a successful mineral exploration geologist who worked (and is still working) around the world as an entrepreneur and geoscientist.

Ms. Brewster worked summer jobs in various segments of the mining business, which led to her employment as a contractor working in the early days of the digitization of exploration data, 3D modeling and data visualization. After working in the capital markets for a time, she returned to the mineral exploration business as a partner in a successful private firm with several employees.

For more information, visit the company’s website at www.RenforthResources.com.

NOTE TO INVESTORS: The latest news and updates relating to RFHRF are available in the company’s newsroom at https://ibn.fm/RFHRF

Annovis Bio Inc. (NYSE: ANVS) Lead Compound Shows Synergistic Cognitive Enhancement

  • Annovis Bio’s lead compound, buntanetap, shows significant enhanced cognitive benefits when combined with GLP-1 agonist dulaglutide in a mouse model
  • Buntanetap targets neurodegenerative conditions like Alzheimer’s and Parkinson’s diseases
  • GLP-1 agonists, typically used for diabetes, weight loss, and heart conditions, have shown potential in addressing neuroinflammation and neurodegeneration
  • The combination treatment results were compelling: While buntanetap alone restored cognitive function to 100% and dulaglutide alone to 80%, the combination restored and also enhanced cognitive function beyond levels seen in healthy controls

Annovis Bio (NYSE: ANVS), a late-stage clinical drug platform company, announced new preclinical data demonstrating lead compound buntanetap’s potential to synergistically enhance cognition when used in combination with the glucagon-like peptide 1 (GLP-1) agonist dulaglutide (Trulicity(R)) in a mouse model of Alzheimer’s disease (https://ibn.fm/9WpKW).

GLP-1 agonists, such as dulaglutide, are known for their ability to manage blood sugar levels in diabetes patients and are also commonly used for weight loss or heart conditions. However, recent research suggests they also have neuroprotective properties, potentially reducing neuroinflammation and supporting neuronal health. When used alongside buntanetap, dulaglutide appears to amplify the cognitive benefits, suggesting a powerful new approach for treating neurodegenerative conditions.

Buntanetap (formerly Posiphen) works by targeting multiple pathways involved in neurodegenerative diseases. It inhibits the production of neurotoxic proteins that lead to the death of neurons, thereby slowing or stopping disease progression. Dulaglutide, on the other hand, activates the GLP-1 receptor, which has been shown to enhance insulin signaling in the brain, reduce inflammation, and promote cell survival. The combination therapy leverages these complementary mechanisms, aiming to provide a more effective treatment option.

The latest preclinical data builds on 2018 research demonstrating how buntanetap fully restored memory, learning, and synaptic potentiation in an Alzheimer’s mouse model. The company now aimed to determine whether buntanetap combined with dulaglutide would produce a synergistic effect in the same animal model. The results were compelling: while buntanetap alone restored cognitive function to 100% and dulaglutide alone to 80%, the combination restored and also enhanced cognitive function beyond levels seen in healthy controls.

“We are excited to see that buntanetap significantly amplifies the effects of dulaglutide on memory and learning, with a 6- to 10-fold increase in efficacy,” said Maria Maccecchini, Ph.D., Founder, President, and CEO of Annovis Bio. “This synergy is particularly important for enhancing treatment outcomes while minimizing potential side effects. As the field of Alzheimer’s research shifts towards combination therapies, we believe our approach holds great promise for offering more effective treatment options for patients.”

The potential for buntanetap combined with dulaglutide to enhance cognitive function represents a significant advancement in the field of neurodegenerative disease treatment. With current treatments offering limited efficacy, this combination therapy could address a critical unmet need in an expanding market.

The neurodegenerative disease treatment market is substantial and growing, driven by an aging population and increasing incidence of conditions like Alzheimer’s Disease. Nearly 7 million Americans are currently suffering from Alzheimer’s Disease, a figure projected to rise to almost 13 million by 2050. Alzheimer’s care costs are expected to reach $360 billion in 2024 and escalate to nearly $1 trillion annually by 2050 (https://ibn.fm/kCfQN). Annovis Bio’s innovative approach with buntanetap, especially when combined with dulaglutide, positions the company to capture a significant market share.

For more information, visit the company’s website at www.AnnovisBio.com, and social channels
LinkedIn, X and YouTube.

NOTE TO INVESTORS: The latest news and updates relating to ANVS are available in the company’s newsroom at https://ibn.fm/ANVS

Fathom Nickel Inc. (CSE: FNI) (FSE: 6Q5) (OTCQB: FNICF): A Canadian Junior Mining Company on the Hunt for Nickel Riches

  • The Trans-Hudson Orogeny (Corridor) stretches hundreds of kilometers across North America and includes a long history of successful mines, while remaining highly underexplored
  • Fathom Nickel owns the commanding land position in the Rottenstone Domain region of the Trans-Hudson Corridor, with 122,000+ highly prospective hectares
  • Fathom Nickel projects include the past-producing Rottenstone Mine, multiple high-grade deposits that remain open in all-directions, mineralization that the company continues to prove via surveys and drilling

Fathom Nickel (CSE: FNI) (FSE: 6Q5) (OTCQB: FNICF) is a Canadian junior mining exploration and development company focused on acquiring, exploring, and developing high-quality nickel, copper, and cobalt deposits. With a particular focus on the Rottenstone Domain of the Trans-Hudson Corridor in Saskatchewan, Canada, Fathom Nickel is actively exploring two key properties: the Albert Lake Property and the Gochager Lake Property. Last month, Fathom Nickel added to its leading land position in the region with the acquisition of the 10,000+ hectare Friesen Lake Project located 40 kilometers southwest of the historic Rottenstone Mine and 30 kilometers northwest of the historic Gochager Lake deposit.

The Trans-Hudson Corridor is recognized worldwide for its expansiveness and massive potential for its yet untapped metal-rich ground. It trends from North Dakota in the U.S. through Saskatchewan where it veers east to include Northern Manitoba, and across Hudson’s Bay to include the Ungava Peninsula, PQ, from where it continues into Greenland. Coincident with the Trans Hudson Corridor are the world-class Thompson Nickel Belt, MN (in production), the Lynn Lake Nickel Belt (past producer), and the Raglan Nickel Belt, PQ (in production).

Fathom Nickel’s Albert Lake property is a promising exploration target. Formerly home to the high-grade Rottenstone Mine, this expansive landholding offers significant potential for magmatic nickel sulfide mineralization. Through the addition of the Tremblay-Olson Claims in 2022, the 100%-owned property now encompasses over 90,000 hectares. Fathom’s ongoing exploration efforts aim to unlock the full potential of this historically productive mining area.

Fathom Nickel’s Gochager Lake Property is a strategic asset. Acquired in stages throughout 2022 and 2023, the property now encompasses over 22,000 hectares. Its prime location within the Proterozoic Trans-Hudson Orogeny, a region renowned for hosting significant mineral deposits, underscores its exploration potential. The property hosts the historic Gochager Lake nickel-copper-cobalt deposit, the Mal Lake nickel occurrence, and the Borys Lake VMS zinc-lead-copper deposit, offering multiple avenues for exploration and development.

Recent Exploration Successes at Gochager Lake:

  • Fathom Announces Mal Lake Nickel-Copper-Cobalt Mineralization: Recent drilling at the Mal Lake occurrence uncovered evidence of nickel-copper-cobalt mineralization, indicating potential for further exploration beyond the historic Gochager Lake deposit.
  • Fathom Continues to Expand the Historic Gochager Lake Deposit: Ongoing drilling programs have shown success in expanding the known boundaries of the Gochager Lake deposit in all directions. This suggests a potentially larger resource base than previously estimated.
  • Fathom Announces Receipt of New Exploration Permit and Commencement of Field Activities: In June 2024, Fathom received a new exploration permit for the Gochager Lake Property, allowing for continued drilling and exploration activities (e.g., 60 drill holes, 25-person camp).

A Staking Frenzy

Fathom Nickel CEO and VP Exploration Ian Fraser has a lengthy history of mining success. His C.V. includes exploration to development at Casa Berardi Gold Mine (Hecla Mining, PQ), Chief Geologist Komis Gold Mine (Waddy Lake Resources, SK), and Cisneros Gold Mine (Antioquia Gold, Colombia SA), amongst others. He recently summarized his excitement for this region when announcing the acquisition of the Friesen Lake property.

“It is very intriguing to us that >1 g/t Pt-Pd occurs in historic surface trenching and that significant Pt-Pd has been confirmed in historic drilling at Friesen Lake. The recent Ramp Metals Inc. drill result announcement has brought a lot of attention to the area and a bit of a staking rush. We felt it was important for Fathom to secure these dispositions and cover these known Ni-Cu-Pd-Pt showings before the staking frenzy grabbed this land ahead of us.”

Fraser was referencing the recent high-grade gold discovery by Ramp Metals of 73.55 g/t gold (“Au”) over 7.5 meters at its Rottenstone SW project that has catapulted the company’s market cap forward several multiples.

Looking Ahead for Fathom Nickel:

The company’s focus soon will be on further exploration and development of its properties in this unfolding prolific region. Management has been incredibly meticulous and methodical in providing and adding to the historic resources, a strategy that will not waver, only accelerate, going forward. Upcoming work will include:

  • Resource definition drilling. Fathom will aim to define the extent and quality of the nickel, copper, and cobalt mineralization at Gochager, Albert, and Friesen Lake projects through continued drilling programs. This will be crucial for attracting potential investors and moving towards mine development.
  • Metallurgical testing. Understanding how the minerals respond to various processing techniques is essential. Metallurgical testing will help determine the optimal methods for extracting the target metals.

Fathom Nickel’s recent exploration successes at the Gochager Lake project speak volumes about the potential for the area of Saskatchewan where it holds a dominant land position. The company’s focus on a historically known mineralized area with evidence of expansion potential and multiple mineral types (nickel, copper, cobalt) is encouraging. Investors interested in the junior mining sector and the potential for nickel exploration success should closely follow Fathom Nickel’s ongoing exploration activities and future announcements.

For more information, visit the company’s website at www.FathomNickel.com.

NOTE TO INVESTORS: The latest news and updates relating to FNICF are available in the company’s newsroom at https://ibn.fm/FNICF

McEwen Mining Inc. (NYSE: MUX) (TSX: MUX) Releases Q2, H1 Financial Results, Key Update on Argentinian Mining Project

  • This has been the company’s most profitable quarter in the last eight years, according to CEO Rob McEwen
  • Revenue was up 38%, driven by an increase in gold prices and the amount of gold equivalent ounces sold
  • Infill drilling at Los Azules copper project has been completed, confirming the geological model and the high-grade zone
  • New Argentinian legislation designed to facilitate foreign investment is expected to significantly improve the economics of the Los Azules project and lower risks for investors

McEwen Mining (NYSE: MUX) (TSX: MUX), an asset rich diversified gold and silver producer in the Americas with a large exposure to copper through its subsidiary McEwen Copper, released its second-quarter and half-year 2024 financial results for the period ended June 30, 2024, along with key updates regarding the current mining situation in Argentina and infill drilling results at its Los Azules project.

According to CEO and Chairman Rob McEwen during a conference call discussing the financial results, this has been the company’s most profitable quarter since 2016, with revenue growing by 38% and overall production costs expanding by 8% quarter-over-quarter. Higher revenues, driven by a 21% increase in realized gold prices and a 13% increase in gold equivalent ounces (“GEOs”) sold also drove improvements in gross profit, which reached $10.8 million in Q2, while adjusted EPITDA was $7.2 million (https://ibn.fm/RjVCr).

Production from the company’s three operating mines (Gold Bar in Nevada, Fox in Ontario, and San José in Argentina) was 35,265 GEOs in Q2, with plans remaining in effect to produce 130,000-145,000 GEOs overall for 2024.

“McEwen Copper continues to grow in value – based on the most recent injection of capital at $30 per share the implied market value is now $947 million, with MUX owning 48.3% or $457 million. That is 106% of MUX’s current fully diluted market capitalization,” McEwen added.

In addition to its silver and gold projects, McEwen Mining also owns a 48.3% interest in McEwen Copper Inc., which holds a 100% interest in the Los Azules copper project in San Juan, Argentina, and the Elder Creek exploration project in Nevada, U.S. During the conference call the company shared important updates regarding the mining situation in Argentina and the latest infill drilling results at Los Azules.

More specifically, Argentine President Javier Milei introduced new legislation encouraging large domestic and foreign investments in the country, offering significant tax and foreign exchange incentives to companies investing in key sectors of the economy, including mining. “We are excited about these changes as they open the door for many infrastructure investments in Argentina and significantly improve the economics of the Los Azules project and lower risks for investors,” the company said (https://ibn.fm/0i7Cc).

Additionally, the world’s largest mining company, BHP, and Lundin Mining recently completed a $4.4 billion joint acquisition of two copper deposits located in the same province in Argentina as McEwen Mining’s Los Azules. “We believe that this transaction is a convincing demonstration of San Juan and Argentina´s attractiveness for large‑scale mining projects and evidence of Argentina moving towards becoming a Tier 1 mining jurisdiction.”

McEwen also reported that infill drilling at Los Azules has been completed and the results are validating the geological model and the high-grade zone at the project. “During the 2023–2024 drilling season, over 70,000 meters were completed, that have strengthened the interpretation of the geological model in addition to extending the supergene enrichment zone mineralization, both at the edges and to depth. Resource drilling for the Los Azules Feasibility Study is now complete, and the study remains on track for delivery in early 2025,” the company said.

A replay of the conference call can be accessed at https://ibn.fm/f2EiB.

For more information, visit the company’s website at www.McEwenMining.com.

NOTE TO INVESTORS: The latest news and updates relating to MUX are available in the company’s newsroom at http://ibn.fm/MUX

Torr Metals Inc. (TSX.V: TMET): A Rising Star in the Next Big Exploration Play

  • Torr Metals is lighting up the map by advancing three high-potential copper and gold projects in Canada, all located in prime mining jurisdictions with increasing M&A activity by major mining companies
  • Each of Torr’s projects boasts key traits sought by majors: high-grades, prime location, robust infrastructure, full project ownership, and significant scalability
  • The company’s assets are situated near major mining operations, including Canada’s largest open-pit copper mine at Highland Valley, within regions rich in mining history and established infrastructure
  • With projects positioned in some of Canada’s most prolific mining regions, Torr Metals is well-placed to attract attention from industry giants

Unparalleled Infrastructure and Strategic Locations

Imagine your exploration project nestled among some of the biggest names in mining—Teck’s Highland Valley Mine, Newmont’s-Imperial Metals Red Chris Mine, and New Gold’s New Afton Mine, just to name a few. That’s where Torr Metals (TSX.V: TMET) finds itself with the Kolos Copper-Gold Project in British Columbia’s Quesnel Trough, a region pulsing with mining history and supported by infrastructure that keeps costs low and operations running year-round. The Kolos Project isn’t just strategically positioned; it’s a short drive away from Canada’s largest open-pit copper mine, connected by highways with easy access to the vibrant mining town of Merritt.

And it doesn’t stop there. Torr’s Filion Project in northern Ontario sits right off the Trans-Canada Highway, with rail and power infrastructure at its doorstep, making it a prime potential target for the next big gold discovery. Then there’s the Latham Project, anchored in BC’s legendary “Golden Triangle,” an area so rich in minerals that even the highways—like Highway 37 transecting the project, currently seeing a $195 million upgrade—seem to glitter with promise.

Full Control and Massive Potential Upside

Torr Metals is sitting on a portfolio of fully owned, high-stakes copper and gold exploration projects with immense untapped potential. With 100% ownership of the Kolos, Filion, and Latham projects, Torr has the freedom to explore, develop, and strike deals without the complications that come with partial ownership. This autonomy gives Torr a powerful edge, making it a highly attractive potential partner joint ventures and strategic investments.

But what truly sets Torr apart is the sheer scale of its ambitions. The Kolos Project spans a whopping 240 km2, nestled in the same geological belt as some of the biggest copper mines in the country. The Filion Project stretches across 261 km2 in an underexplored greenstone belt, ripe for high-grade orogenic gold discovery potential. And the Latham Project? It’s a mammoth 689 km2 playground with an existing copper-gold porphyry deposit at Gnat Pass, located adjacent to Highway 37 within the “Golden Triangle,” a region renowned for its world-class mineralization.

A Future Forged in Critical Minerals

As the world races towards a clean energy future, Torr Metals is poised to be a key player, exploring the critical and precious minerals that will power tomorrow. With projects that tick all the boxes — high grade, prime location, infrastructure, ownership, and scalability—Torr Metals stands out as a beacon of opportunity in the mining sector. As the company ramps up its exploration efforts, it’s clear that the future is bright and full of potential.

For more information, visit the company’s website at www.TorrMetals.com.

NOTE TO INVESTORS: The latest news and updates relating to TMET are available in the company’s newsroom at https://ibn.fm/TMET

D-Wave Quantum Inc. (NYSE: QBTS) Sees Double Digit Growth in 1H 2024 Training Enrollments with Workforce Development Initiative

  • The “Quantum Programming Core” course experienced a 53% rise in enrollments, while total enrollments, including both the “Core” and “Foundations for Quantum Programming” courses, increased by 85%
  • D-Wave provides access to its Leap(TM) quantum cloud service in 42 countries, allowing learners to utilize D-Wave software and tools including the Ocean(TM) SDK
  • Nearly 90% of learners that have completed a D-Wave training course recommend it

D-Wave Quantum (NYSE: QBTS), a leader in quantum computing systems, software, and services, and the first commercial provider of quantum computers, recently announced a significant increase in enrollment for its quantum training courses. In the first half of 2024, the enrollment numbers saw double-digit growth compared to the same period in 2023 (https://ibn.fm/n5wXd).

The “Quantum Programming Core” course experienced a 53% rise in enrollments, while total enrollments, including both the “Core” and “Foundations for Quantum Programming” courses, surged by 85%. This notable growth highlights a global effort to train workers to meet the rapidly expanding demand for quantum computing expertise.

“With rapidly increasing demand for quantum-ready talent and a shortage of quantum-trained workers, we’re at a critical crossroads with quantum education,” said Victoria Goliber, D-Wave’s head of technical advising. “Our learning solutions foster an environment of experimentation and innovation that helps streamline and expedite skills training to prepare the workforce now in order to meet the growing need for quantum optimization capabilities.”

This surge in demand for quantum programming skills is driven by forecasts indicating that less than half of all anticipated quantum computing job openings will be filled by 2025, as reported by McKinsey. Supporting this prediction, a 2024 Hyperion Research survey commissioned by D-Wave revealed that businesses currently utilizing quantum computing cite the lack of in-house quantum expertise as a major challenge. Furthermore, nearly all government quantum initiatives across various countries, including Australia, Canada, the European Union, Japan, the United Kingdom, and the United States, now prioritize quantum workforce development.

To address this need, D-Wave offers accessible and thorough training solutions to prepare professionals for success in the quantum computing field. The “Foundations for Quantum Programming” course is designed to help beginners develop their math and Python skills, leading up to the more advanced “Quantum Programming Core” course. As part of its global workforce development efforts, D-Wave provides access to its Leap quantum cloud service in 42 countries, allowing learners to utilize D-Wave software and tools including the Ocean SDK. In Canada, students, staff, and researchers at post-secondary institutions can access D-Wave technology for free through the Leap service, thanks to an expanded training initiative in collaboration with Canada’s Quantum Algorithms Institute.

“In most of the data analytics teams, we don’t represent problems in a binary format, which is generally required to work with a quantum computer,” said Ziya Dalkılıç, data scientist at Ford Otosan, a joint venture between Ford Motor Company and Koç Holding, an industrial conglomerate based in Turkey. “I think it is quite important to learn how to represent those problems in the fashion that a quantum computer needs. This course has been fundamental in providing that knowledge before tackling a real-world problem.”

D-Wave’s training program emphasizes practical applications rather than theoretical concepts and physics. It demonstrates how quantum computing can address real-world problems such as workforce scheduling, logistics routing, production planning, and resource allocation. Nearly 90% of learners that have completed a D-Wave course recommend it, appreciating the well-structured, easy-to-follow materials and the practical approach tailored for individuals with minimal coding experience.

For more information, visit the company’s website at www.DWaveQuantum.com.

NOTE TO INVESTORS: The latest news and updates relating to QBTS are available in the company’s newsroom at https://ibn.fm/QBTS

Forward Looking Statements

Certain statements in this press release are forward-looking, as defined in the Private Securities Litigation Reform Act of 1995. These statements involve risks, uncertainties, and other factors that may cause actual results to differ materially from the information expressed or implied by these forward-looking statements and may not be indicative of future results. These forward-looking statements are subject to a number of risks and uncertainties, including, among others, various factors beyond management’s control, including the risks set forth under the heading “Risk Factors” discussed under the caption “Item 1A. Risk Factors” in Part I of the company’s most recent Annual Report on Form 10-K or any updates discussed under the caption “Item 1A. Risk Factors” in Part II of the company’s Quarterly Reports on Form 10-Q and in the company’s other filings with the SEC. Undue reliance should not be placed on the forward-looking statements in this press release in making an investment decision, which are based on information available to the company on the date hereof. The company undertakes no duty to update this information unless required by law.

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