• Trxade Group reported record revenues of over $1.9 million in its second quarter filing, as well as increased operating income and net income obtained through its acquisition of independent pharmacy services
• Trxade Group is a pharmaceutical services network dedicated to helping independent pharmacies remain competitive through its web-based purchasing platform, data analytics and delivery services
• Trxade also reported a year-over-year increase in operating income, from $31,446 to $132,705, and net income, from $20,513 to $57,981
• Gross profits rose to more than $1.1 million, with a gross margin of 60.7 percent offset by increased cost of sales from one of the company’s acquisitions

Florida-based Trxade Group Inc. (OTCQB: TRXD), a pharmaceutical services network that brings the buyers and sellers of pharmaceutical products and services together in its own community of trust, technology and transparency, reported ongoing record revenue growth as well as an increase in gross profits and independent pharmacy subscribers as part of its second-quarter financial statement.

Trxade reported that its revenues for the three months ended June 30 were over $1.9 million, marking an increase of 129 percent over the year-ago quarter’s $837,688. It also marked a 27 percent sequential increase over the first quarter ended March 31, according to a news release issued July 29 (http://ibn.fm/1uFir).

Operating income rose during the quarter to $132,705, versus $31,446 a year ago. Net income increased to $57,981 from last year’s second quarter report of $20,513. The gains in revenue and income were primarily attributed to the acquisition of Community Specialty Pharmacy LLC and an increase of fee income generated by the company’s web-based supplier-to-pharmacy trading platform.

Gross profit for the quarter was over $1.1 million, which created a gross margin of 60.7 percent for the three-month period, as compared to $837,688 and 100 percent respectively for the second quarter of the previous year. The margin decrease was attributable to greater revenues mixed with higher costs of sales from its acquisition of independent pharmacy services.

“We made excellent progress executing against our key strategic priorities in our Delivmeds.com program, our B2C commercial efforts and our proprietary B2B trading platform www.Trxade.com… enabling us to experience top and bottom line growth,” Trxade Group Chairman and CEO Suren Ajjarapu stated in a news release. “Accordingly, I am optimistic that our new product lines will generate profitability as increasing pharmaceutical prices drive independent pharmacies, payors and consumers to be more aggressive in sourcing medication.”

Trxade Group’s resources, which include software that links a member-pharmacist network, a platform for buying medications at competitive prices and services for storing and delivery pharmaceuticals, are designed to empower independently owned pharmacies and help them manage their inventories and operations through data analysis.

For more information, visit the company’s website at www.TrxadeGroup.com

NOTE TO INVESTORS: The latest news and updates relating to TRXD are available in the company’s newsroom at http://ibn.fm/TRXD

• The home video services industry is undergoing a significant evolution, as younger consumers increasingly edge away from traditional cable TV and gravitate toward streaming services that are viewable on mobile devices
• End-to-end network technology provider Spectrum Global Solutions has positioned itself well to meet the evolving industry’s infrastructure and ongoing maintenance needs
• The company serves clients large and small throughout the United States and its territories, including telecommunications giants such as Ericsson, Nokia, Sprint, AT&T and Verizon
• SGSI’s acquisition of German energy infrastructure technology company WaveTech GmbH further positions its operations to respond to clients on an international scale

Online video streaming services were introduced to the television-viewing market as an alternate means of watching programming that hadn’t been DVR’d, sometimes providing supplementary content as well, but streaming services have since begun to evolve into content-providing solutions with gravitas, and current global telecommunications industry plans to begin rolling out the infrastructure for a 5G network evolution have further validated a shifting business focus toward over-the-top (OTT) services as well as cable TV.

Telecommunications network service provider Spectrum Global Solutions Inc. (OTCQB: SGSI) delivers network establishment and maintenance experience end-to-end, fulfilling contracts on a one-time service-needed basis as well as ongoing, multi-year contracts. The holding company’s client list includes carriers, aggregators, enterprise services, project management offices (PMOs) and original equipment manufacturers (OEMs) large and small, with names such as Ericsson, Nokia, Sprint, AT&T and Verizon among them.

SGSI serves telecommunications engineering and infrastructure needs across the United States, Canada, Puerto Rico, Guam and the Caribbean. A July announcement of its pending acquisition of German energy infrastructure technology company WaveTech GmbH paves the way for further expansion into the global market (http://ibn.fm/NWzcw) and shows Spectrum’s potential to respond to differing needs in the world’s varied locales.

European internet users are generally less likely to watch video on a smart TV or smartphone than their U.S. counterparts, according to research from Ampere Analysis (http://ibn.fm/pQzvb), and the trend by which viewers worldwide continue to prefer connected TVs for long-form programming is expected to hold steady so long as significant video quality and streaming rate concerns remain outside of metropolitan areas. Still, the rise of global internet firms and changing viewing habits, particularly among younger generations, is increasing the pressure on traditional pay-TV and free-to-air broadcasters (http://ibn.fm/Yi8yv).

“Younger generations are growing up with more choices at their fingertips,” Peter Katsingris, senior vice president of audience insights at Nielsen, told USA Today (http://ibn.fm/EX7xQ) after noting that the percentage of 18-to-34-year-olds watching TV in a given minute dropped from 26.4 points in 2014 to 16.8 percentage points by late 2018 — a change of 36 percent overall. The younger “Gen Edge” demographic has dropped its traditional TV viewing in favor of streaming services in even larger numbers — close to 50 percent overall — according to the company.

Spectrum’s subsidiaries have provided the company the capacity to thrive amid the evolving industry landscape. AW Solutions Inc. and AW Solutions Puerto Rico LLC offer full turnkey service solutions for wireless and wireline clientele in all the contiguous states, the District of Columbia and Hawaii, as well as in the Canadian provinces of British Columbia, Quebec, Ontario, Alberta and Newfoundland and Labrador, and in Puerto Rico, Guam and the U.S. Virgin Islands.

SGSI’s ADEX Corp. and ADEX Puerto Rico LLC subsidiaries provide turnkey network deployment services and staffing solutions to telecommunications carriers and enterprise clients on an international basis. Tropical Communications Inc., an electrical and underground utility contractor headquartered in Miami, Florida, and TNS Inc., headquartered in Des Plaines, Illinois, both provide all types of structured wiring and installation services to enable private and public communication networks.

For more information, visit the company’s website at www.SpectrumGlobalSolutions.com

NOTE TO INVESTORS: The latest news and updates relating to SGSI are available in the company’s newsroom at http://ibn.fm/SGSI

• Cannabis industry investment builder Nabis Holdings has purchased Desert Hot Springs’ Desert’s Finest dispensary
• The new asset gives Nabis an entry point into the world’s largest cannabis industry market, and it is strategically located near the annual Coachella Music Festival
• Nabis envisions revenues of C$14.8 million this year with a leap to C$167.9 million next year, translating into forecasts of C$4.1 million in profits this year and C$67.5 million in 2020

The remarkable rise of the cannabis industry and its variety of sectors has created a sea change in some market metrics, drawing investors’ risk capital from last year’s newsmakers (http://ibn.fm/R8ubX). At the forefront of the trend, Nabis Holdings Inc. (CSE: NAB) (OTC: NABIF) (FRA: 71P) has been plying its experience in building an expanding portfolio of cannabis investments to create high-quality cash flow opportunities in states where limited licenses are granted for professional operations.

Nabis entered new territory with its first acquisition in California – the world’s largest market for the cannabis industry – which it announced in a June 12 news release noting a definitive agreement to acquire 100 percent ownership of Desert’s Finest, a 6,000-square-foot dispensary located in Desert Hot Springs, less than two hours east of Los Angeles (http://ibn.fm/9V5Jg).

“As we continue national expansion of the Nabis footprint, we are pleased to announce our first acquisition in the state of California, one of the dominant cannabis markets in the United States,” Nabis CEO and Director Shay Shnet stated in a news release. “Desert’s Finest has successfully generated material revenue driven in part by their convenient dispensary location in the Palm Springs region and extensive list of registered patients.”

The dispensary has more than 37,000 registered patients and brought in more than $5.7 million in revenues over the previous 12 months, leaving it with a 47 percent gross profit margin. Desert’s Finest’s location, strategically close to the annual Coachella Music Festival, has also shown to be a boon to sales of a wide assortment of flower, vape and edibles products.

Nabis expects that its portfolio of investments at a proper pricing point supports revenue forecasts of C$14.8 million this year followed by a leap to C$167.9 million next year as the company’s assets begin reaping the benefits of cultivation and harvest work. Most of those are due to expectations for strategically located assets in Michigan, where the company is building a pipeline of one cultivation facility, one processing facility and seven dispensaries.

Nabis expects the sales to translate into EBITDA of C$4.1 million in 2019 and C$67.5 million in 2020 (http://ibn.fm/5sMQa) as it builds a vertically integrated portfolio across the United States and expands into international markets.

The company’s investments include a cannabis cultivation facility, a greenhouse and a dispensary in Arizona, as well as a growing processing facility operation in Washington. In Israel, Nabis recently announced its 49 percent interest in sublingual cannabis strip maker Cannova Medical Ltd., with an option to purchase the remaining 51 percent at the company’s discretion.

Nabis also is examining multiple “off market” opportunities in Massachusetts, Nevada, Ohio, Oklahoma, Oregon and the European Union.

For more information, visit the company’s website at www.NabisHoldings.com

NOTE TO INVESTORS: The latest news and updates relating to NABIF are available in the company’s newsroom at http://ibn.fm/NABIF

• PBIO’s proprietary Ultra Shear Technology (UST) platform achieves the long sought-after ability to create truly water-soluble CBD oil that can provide optimized bioavailability
• CBD sales are projected to reach $89 billion by 2024 with a CAGR of 37 percent (2018-2024 forecast period)
• Analysts predict that the biggest short-term challenge for CBD businesses will be oversaturation and stiff competition in the marketplace; companies producing the highest-quality, most bioavailable CBD products are expected to earn top customer loyalty

Finding success in the lucrative yet ultra-competitive CBD industry is a daunting challenge for businesses in the space, with oversaturation in the marketplace being a real concern. The cannabis market was valued at $14.5 billion in 2018 and is projected to reach $89.1 billion by 2024, with a compound annual growth rate of 37 percent during the forecast period, according to Mordor Intelligence (http://ibn.fm/fCnCI). CBD manufacturers may find tapping into this booming trend to be short-lived if their CBD offerings don’t stand up to consumers’ expectations that the products they purchase are as beneficial as advertised.

Pressure BioSciences Inc. (OTCQB: PBIO), a leader in the development and sale of high pressure-based instruments, consumables and related services for the global life sciences and other industries, has developed a novel, proprietary process that has wide potential in the cannabis sector by solving one of the most critical problems facing CBD manufacturers today: the extremely poor water solubility of CBD oil. The recent launch of PBIO’s BaroShear K45 system, based on the company’s proprietary Ultra Shear Technology (UST) platform, has been optimized for the unique purpose of creating high quality, water-soluble nanoemulsions of CBD oil in water, as a news release details (http://ibn.fm/MY4mE).

CBD, a non-psychoactive compound believed to offer powerful health benefits, is extracted from the cannabis plant in an oil. After ingestion, because oils are not well absorbed, most of the CBD is flushed from the body, leaving little of the product to provide its beneficial properties. Because of these solubility issues, many CBD products on the market today contain an inefficient over-abundance of CBD and/or undesirable chemicals to try and improve solubility and bioavailability.

Dr. Nathan Lawrence, senior advisor to Pressure BioSciences, said that PBIO solves the water-solubility problem of CBD with its patented UST platform, which uses ultra-high pressure to create extreme shearing forces to make highly stable, homogenized nanoemulsions of materials that normally do not mix, such as CBD oil and water.

“The unique concept of the BaroShear K45 system is based on PBIO’s proprietary UST platform. It was designed for the efficient and affordable manufacture of limited quantity oil-based material into high quality, water-soluble nanoemulsions,” Dr. Lawrence stated in a news release. “The BaroShear K45 system uses a custom-designed, highly responsive ultra-high pressure generating subsystem, matched to our patented BaroIsolator device and NanoGap valve. This allows for the highest effectiveness possible at working pressures up to 45,000 psi. The BaroShear K45 system is ideally suited for processing small amounts (e.g., 50 mL – 2 L) of high value product, such as CBD oil, into water-soluble nanoemulsions with high yield.”

In a critical review report on cannabidiol (CBD), the World Health Organization’s Expert Committee on Drug Dependence noted that, while CBD is seen as a useful treatment for a number of medical conditions, there are efficacy issues because of its “poor aqueous solubility.”

“The absorption of CBD from the gastrointestinal tract is erratic, and the resulting pharmacokinetic profile is variable. Bioavailability from oral delivery was estimated to be 6 percent due to significant first-pass metabolism,” the report states (http://ibn.fm/k9TiL).

For most oil-based products, the ability to prepare them as nanoemulsions can improve the product’s absorption, medicinal benefits, visual appearance and sensory presentation. The biggest challenge in the short-term for CBD businesses will be oversaturation and stiff competition, a Forbes article notes (http://ibn.fm/rq67C). As consumers start to learn more about CBD and approach products with more discerning tastes, companies will need to start differentiating themselves from their competitors through smart branding and the delivery of excellent products.

Two short videos released by PBIO (http://ibn.fm/T4eUX and http://ibn.fm/ENM6e), showing how its patented UST platform was able to process CBD plant oil into a water-soluble nanoemulsion, give a quick lesson in PBIO’s proprietary technology. When the UST-processed CBD oil was added to different liquids – such as a soft drink, a sports drink and a beer – the nanoemulsified CBD oil completely dissolved in each liquid. For CBD companies seeking a way to stand out from the rising hordes of competition, PBIO’s BaroShear K45 system could be a true game changer.

“We are looking forward to working with the early adopters of this exciting technology platform,” Richard T. Schumacher, president and CEO of PBIO, said in a news release. “Early adopters will be the first to use the UST platform in the CBD field, thus giving them a significant head-start over companies who choose to wait or use other methods.”

For more information, visit the company’s website at www.PressureBioSciences.com

NOTE TO INVESTORS: The latest news and updates relating to PBIO are available in the company’s newsroom at http://ibn.fm/PBIO

• City View Green Holdings is completing the construction of a 40,000-square-foot cannabis cultivation facility in the Toronto-area following an all-clear notice from Health Canada under its new licensing regulations
• City View began trading on the Canadian Stock Exchange in March and has recently cleared more than half a million dollars in debt as part of efforts to strengthen its financial profile
• The company expects its 19.9 percent stake in Canadian retailer Budd Hutt to provide it with an avenue for gaining shelf space in Alberta and for other retail opportunities across the country
• CVGR’s fledgling operation has the benefit of an experienced leadership team, including a CEO with decades of sales and leadership experience in the alcoholic beverage industry and a master grower who co-founded a TSX Venture Exchange-listed cannabis firm
• The cannabis industry is expected to achieve $66.3 billion in sales by the end of 2025

Vertically integrated cannabis company City View Green Holdings Inc. (CSE: CVGR) is pressing forward with its efforts to establish strong operational and financial resources for its green seed-to-retail strategy, building on recent budget-strengthening developments as it completes a 40,000-square-foot cultivation facility near Toronto for a pharmaceutical-grade crop.

City View Green Holdings announced July 24 that it had negotiated the settlement of $580,019 in debt with arm’s length creditors in exchange for an established number of shares at differentiated values. It also detailed negotiated terms for a sale and leaseback transaction related to its Toronto-area property in Brantford, Ontario, and for consultancy services, in exchange for warrants to purchase additional shares and other stock options (http://ibn.fm/s0M85).

CVGR expects to complete buildout at the Brantford facility during the coming months and to position itself for growing, extraction, production and retail services targeting the extract market and, once legalized, edibles, distillates and water-soluble products for the cannabis-infused beverage market. The company’s 19.9 percent stake in Canadian retail outlet Budd Hutt Inc. grants it a channel of opportunity for securing shelf space in Alberta and other retail opportunities across the country.

Budd Hutt has entered an agreement to acquire eight pre-license retail cannabis store locations in the Alberta market, all of which have the appropriate regulatory approvals in place except for pending approval from Alberta Gaming, Liquour and Cannabis (http://ibn.fm/TPMLC).

Health Canada has granted City View Green the go-ahead to continue building up its operation under new Cannabis Act & Regulations licensing rules announced May 8 that require new license applicants to have a fully built site at the time of submitting applications (http://ibn.fm/edC0l). CVGR received notice from Health Canada that there were no concerns under the proposed application following a high-level review, which paves the way for CVGR’s application to be fast-tracked once the Brantford site is finished (http://ibn.fm/Ilecc).

Following receipt of Health Canada’s letter, City View reported that preparation of the facility’s exterior, security fencing and interior has been completed, and the company expects to finish building the initial cultivation and extraction rooms during the second and third quarters of the current calendar year.

“We are excited to maintain our priority in the licensing process with Health Canada,” CEO Ian MacDonald stated in the news release. “With the recent changes announced to the application process, we believe timelines for inspection and approvals will be greatly improved and the value of a license will increase significantly. The new rules give priority to applicants like CVGR with strong operational and financial resources. Our buildout at our Brantford facility will be completed in the coming months and we are confident our license will be granted shortly thereafter so we can begin operations and provide the finest flower and oils in the cannabis industry.”

MacDonald was named CEO in April, shortly after the company began trading on the Canadian Stock Exchange, bringing CVGR the benefit of his distinguished career in the international alcoholic beverage industry that includes a strong foundation in sales, marketing and executive management over 30 years. The company’s leadership team also includes a master grower who helped found successful cannabis firm WeedMD.

City View is anticipating the purchase of processing equipment, the roll out of a direct route to market QSR (Quick Service Restaurant) concept and the acquisition of other products as part of its strategy going forward into world markets where medicinal and adult recreational use cannabis have been granted legal acceptance.

The legalized cannabis industry has enjoyed explosive success amid changing cultural perspectives and governmental regulatory approaches across the globe. Analysts at market observer Grand View Research anticipate that the worldwide legal cannabis market will expand at a CAGR of 23.9 percent through the end of 2025 to achieve $66.3 billion in sales (http://ibn.fm/2tygb).

For more information, visit the company’s website at www.CityViewGreen.ca

NOTE TO INVESTORS: The latest news and updates relating to CVGR are available in the company’s newsroom at http://ibn.fm/CVGR

• City View Green Holdings and Budd Hutt recently announced an agreement to acquire eight retail cannabis store locations in Alberta
• The potential economic impact of legalized adult-use cannabis in all its forms, along with transportation, licensing fees and security, is estimated at more than $22 billion in Canada
• City View’s focus is on growing high quality flower and creating premium edible offerings, distillates and water-soluble products

City View Green Holdings Inc. (CSE: CVGR), a vertically integrated cannabis company focused on seed to retail, is creating a diversified company that investors can appreciate. City View has successfully attracted top talent in a time when competition is fierce among firms looking to solidify their positions in the quickly growing cannabis marketplace.

Mike Hagopian, City View’s chief operations officer and “extraction guru,” is a case in point. He most recently served the same role at Dose Oil, a licensed processor of cannabis extracts in Seattle, Washington. Hagopian will help develop City View’s unique cannabis extract brands, as an article featuring the company states.

The company’s master grower/managing partner is Mario Meek, whose deep knowledge of the cannabis space includes 10 years of networking, growing and cultivation experience in the medical cannabis industry. Meek was an original founding partner of WeedMD and is experienced in every aspect of growing marijuana, from seed to the finished product.

Both men bring strong operational and creative forces to City View’s vision, which will soon be on display at the company’s facility in Brantford, Ontario. Plans to retrofit and buildout the 40,000 square foot space are underway, a news release states (http://ibn.fm/idarb). Importantly, City View has maintained its priority position in the licensing process with Health Canada, City View Green CEO Ian MacDonald confirmed in the release.

“With the recent changes announced to the application process, we believe timelines for inspection and approvals will be greatly improved and the value of a license will increase significantly,” MacDonald stated. “The new rules give priority to applicants like CVG with strong operational and financial resources. Our buildout at our Brantford facility will be completed in the coming months and we are confident our license will be granted shortly thereafter so we can begin operations and provide the finest flower and oils in the cannabis industry.”

City View also recently entered into an agreement to expand its brick-and-mortar footprint in the Canadian retail cannabis marketplace with Budd Hutt, the company’s retail arm that owns a 19.9 percent stake in City View, according to a news release (http://ibn.fm/38ROv). Budd Hutt plans to initially enter the Canadian retail cannabis marketplace through Alberta and intends to acquire eight pre-license retail cannabis store locations in the Alberta market. These stores have already obtained the appropriate regulatory approvals and are waiting on final approval from Alberta Gaming, Liquor and Cannabis (AGLC), which is expected before the end of 2019. The company plans to establish a flagship location in Alberta that will serve as a showpiece for the future of the proposed national retail chain.

For more information, visit the company’s website at www.CityViewGreen.ca

NOTE TO INVESTORS: The latest news and updates relating to CVGR are available in the company’s newsroom at http://ibn.fm/CVGR

• Direct Solar achieved more than $3 million in solar contracts in just 60 days
• SING has expanded into the commercial solar market, opening up additional revenue streams
• CEO shared news from multiple revenue streams on MoneyTV with Donald Baillargeon

SinglePoint Inc. (OTCQB: SING) is a well-diversified holding company. What started as a full-service, mobile-technology provider has grown into a recognized brand with multiple revenue streams. A recent acquisition in alternative energy has exceeded the company’s expectations, and growth is abundant across all of the company’s revenue streams.

Direct Solar, a subsidiary of SING, is a leading solar energy brokerage providing customers no upfront cost and the potential to save up to 50 percent off of their electricity bills. The company finds and installs the best available solar energy system for any residential or commercial building. In May 2019, SING acquired Direct Solar with the expectation of dramatically increasing revenues by more than $5 million in the first 12 months (http://ibn.fm/WISdE).

Direct Solar is currently on track to exceed those expectations, Contracting approximately $3.4 million in only two short months (http://ibn.fm/c975T). The company has found a unique niche in the solar market. As solar becomes more mainstream, SING and Direct Solar are optimistic about the future. Currently operational in eight states, Direct Solar has also begun to offer renewable energy options to larger-scale commercial projects.

This month, SING announced that Direct Solar signed its first funding agreement to supply small to medium commercial outfits with solar financing (http://ibn.fm/aRMr9). This gives Direct Solar the ability to supply the contractor for installation and finance the transaction for the business, all in one package, marking the first time that this financing option has been available to commercial operations of this size. “We have a pipeline of interested businesses that we now have the ability to finance,” Direct Solar CEO Pablo Diaz stated in a news release. “It is a completely untapped market in my opinion, with a high chance for major success.”

Diaz recently sat down with SING President Wil Ralston to explain the market opportunity and services that Direct Solar provides to both customers and contractors (http://ibn.fm/fJ0ZR). As Diaz mentioned, once customers see all that solar energy has to offer them economically, “solar sells itself.” This sentiment can be seen in Direct Solar’s incredible growth, generating $3.4 million in just 60 days. As more states discover the positive economic value of alternative energy, Direct Solar expects to continue to grow.

In a separate interview, SING CEO Greg Lambrecht joined Donald Baillargeon on MoneyTV (http://ibn.fm/lRDAM) to discuss growth across the company’s multiple revenue streams. The two discussed the exceptional growth of Direct Solar since its acquisition. The company is on track to bring in the $5 million that was anticipated in the first 12 months in only the first quarter. Lambrecht also shared news regarding SING’s investment in the CBD and hemp markets. He discussed a new product line called PURE Hemp Cigarette that contains zero nicotine and is all natural. SING is currently in discussion with the manufacturer of the product to become the only sales and marketing team to take PURE to market. The hemp cigarette is expected to be available at SingleSeed.com, but Lambrecht sees it being placed in traditional large retail vendors and convenience stores, as well.

In addition, SING is looking forward to continued growth across other revenue streams. “SING is undervalued, and in my opinion, it is headed in the right direction,” Lambrecht stated enthusiastically at the close of the interview. “So, go SING.”

SinglePoint specializes in acquisitions of small- to mid-sized companies, with an emphasis in new technologies, as well as providing investors with the opportunity to make investments across a wide range of assets, including payment processing, cannabis and renewable energies.

For more information, visit the company’s website at www.SinglePoint.com

NOTE TO INVESTORS: The latest news and updates relating to SING are available in the company’s newsroom at http://ibn.fm/SING

• California-based INmune Bio is developing therapies to battle cancers and Alzheimer’s disease by more effectively engaging the body’s own natural defenses
• Research published in a peer-reviewed scientific journal shows a mechanism by which scientists can track and strategize natural killer cell promotion as an innate physical response to cancer in lieu of other pharmaceutical inducements
• INmune Bio’s INKmune product, derived from the cell line used in its research, naturally targets “residual disease” cells that may survive other cancer treatments and revitalize themselves to create a relapse of cancer

The battle to marshal naturally occurring cells within the human body to destroy cancerous tumors has gained new intelligence that appears to strengthen an immunotherapy strategy employed by clinical-stage biotechnology company INmune Bio Inc. (NASDAQ: INMB). The encouraging report arises from research on tumor-primed vs. cytokine-primed human natural killer (NK) cells, published in June in peer-reviewed, open-access scientific journal PLOS ONE (http://ibn.fm/HuKXg).

“We are delighted to be sharing these data describing the unique molecular pathways triggered within human NK cells upon priming with INmune Bio’s own INB16 (INKmune) cell line,” INmune Bio co-founder and Chief Scientific Officer Dr. Mark Lowdell, who co-authored the study, stated in a news release announcing the publication (http://ibn.fm/LYvqj). “This work has combined expertise across many groups, and it was important to publish these data in a highly-regarded open access journal to ensure that they are available to the widest possible audience.”

INmune Bio is a clinical stage immuno-oncology company focused on successfully harnessing patients’ immune systems to treat cancer by targeting cells that may survive initial therapies and become resurgent to cause a relapse of the cancer. By controlling these “residual disease” cells, INmune Bio hopes to enable patients to live longer through a novel mechanism of action and a precision medicine approach that suppress or eliminate relapses.

The company’s INKmune drug is a biologic therapy that strives to activate the body’s innate immune system by “priming” NK cells that are at rest to go on alert, seek out and destroy cancerous cells. The therapy uses simple IV infusion of the INKmune cell line – a tumor cell product – to call up the NKs for duty.

The PLOS ONE report notes that the research comparing tumor cell activation to the results from increasingly popular work on cytokine-mediated activation (http://ibn.fm/A9UXg) shows that the two therapies demonstrate distinct effects and that tumor therapy has the potential to be more effective against cancer targets with potentially fewer side effects than the administration of cytokines such as IL-2 or IL-15.

The research paper identifies a unique signaling “fingerprint” expressed by NK cells after binding to CTV-1 tumor cells, which are the parent clones of INmune Bio’s INB16 cells. Scientists are then able to use data obtained from the “fingerprint” to build strategies for immunotherapy treatments.

Lowdell went on to state, “These data confirm that the primed NK cells generated by INB16 stimulation upregulate genes, which are crucial to NK-mediated killing of patients’ cancer cells, such as CD70 and CXCL10. These differences in gene expression may explain the greater cytotoxic activity of INB16 primed NK cells in vitro compared to cytokine primed cells which may lead to greater clinical efficacy.”

INmune Bio is also completing testing of its INB03 product, a checkpoint inhibitor that targets myeloid-derived suppressor cells (“MDSC”) that may produce a “shield” preventing a patient’s immune system from attacking cancer cells. The company is also exploring Alzheimer’s disease therapies using its XPro1595 product that targets the microglial immune cells of the brain, which may cause neuroinflammation that can kill nerve cells and promote synaptic dysfunction in the brain.

For more information, visit the company’s website at www.INmuneBio.com

NOTE TO INVESTORS: The latest news and updates relating to INMB are available in the company’s newsroom at http://ibn.fm/INMB

• Supreme’s Truverra acquisition is valued at approximately C$20 million
• Supreme Cannabis intends to repurpose Truverra’s Health Canada-licensed facility to produce cannabis extracts for use in concentrates and vaping liquids
• The company will gain entry into Europe through Truverra’s subsidiary

The Supreme Cannabis Company Inc. (TSX: FIRE) (OTCQX: SPRWF) (FRA: 53S1) intends to acquire privately held, Toronto-based Truverra Inc. in a three-cornered amalgamation between Truverra, Supreme Cannabis and a wholly owned subsidiary of Supreme Cannabis. The transaction for 14.7 million common shares of Supreme Cannabis has a value of approximately C$20 million (http://ibn.fm/3Itkx).

Truverra’s Health Canada-licensed facility in Toronto, Ontario, will produce cannabis-derivative products for Legalization 2.0, an industry term for a second wave of regulations in Canada anticipated for fall 2019. Companies such as Supreme Cannabis are positioning themselves for this new growth opportunity (http://ibn.fm/vZVDR).

The transaction has been unanimously approved by the Supreme Cannabis and Truverra boards, as well as a special Supreme Cannabis committee. The closing is subject to Truverra receiving requisite approval from its shareholders at a special meeting. The transaction is expected to close prior to August 30, 2019 (http://ibn.fm/zRQJs).

Truverra is a private cannabis company that sells to Canada and the international cannabis markets through its subsidiaries, Truverra (Europe) B. V. and Canadian Clinical Cannabinoids Inc. (CCC). Truverra Europe, a wholly owned subsidiary based in the Netherlands, already sells a broad portfolio of hemp-based CBD products into European markets.

“With the acquisition of Truverra, we secure a Toronto-based facility equipped to extract our high-quality inputs for concentrates and vaping liquids in the near term,” Supreme Cannabis CEO Navdeep Dhaliwal stated in a news release. “Truverra’s operations also provide an additional entry point into Europe’s CBD wellness market, where Truverra Europe has successfully launched multiple CBD products in various jurisdictions.”

Supreme Cannabis announced that it was planning to retrofit Truverra’s Health Canada-licensed, 5,000-square-foot facility in Ontario to produce both solvent and solvent-less concentrate and leverage its position as a cannabis producer with premium flower at scale.

The Truverra acquisition will also provide Supreme Cannabis with opportunities to address the international medical market. The announced agreement notes that Truverra would serve as Supreme Cannabis’ global medical brand, building on an existing R&D platform and established CBD offerings within Europe.

Supreme Cannabis is a Toronto-based company that is pursuing opportunities and generating sustainable growth in what it sees as a global emerging market. The company’s portfolio includes 7ACRES, an award-winning brand; Cambium Plant Sciences, a cultivation IP and plant-genetics company; Medigrow Lesotho, a Southern Africa cannabis oil producer; Supreme Heights, an investment platform focused on CBD; and a brand partnership and licensing deal with Khalifa Kush Enterprises Canada.

For more information, visit the company’s website at www.Supreme.ca

NOTE TO INVESTORS: The latest news and updates relating to SPRWF are available in the company’s newsroom at http://cnw.fm/FIRE

• China’s AR industry is estimated at RMB$55 billion in 2020
• Favorable Chinese government policies emphasize research and development of new technologies such as AR
• Few direct competitors in China create exceptional potential for AR application in educational materials and smart toys
• Total retail sales of toys and games in China soared to RMB$276.5 billion in 2017 with an annual growth rate of 19.9%
• Shift toward intelligent and interactive toys and games, along with rising disposable income in China, helped retail sales of electronic toys grow 24% while traditional toys grew at 7% in 2017
• Extensive portfolio of IR property with strong research and development teams and partnerships

Blue Hat Interactive Entertainment Technology (NASDAQ: BHAT) is a cutting-edge creator, developer and operator of popular augmented reality (“AR”) interactive smart toys and educational games in China. Blue Hat’s mobile-connected entertainment platform connects physical items to mobile devices through wireless technologies, creating a unique interactive user experience in various mobile games, interactive educational materials and toys with mobile game features.

Blue Hat designs original toys and games that utilize augmented reality technology, motion capture technology, image recognition technology, voice control, light sense technology, infrared, levitation induction, and other trending scientific technologies to transverse the virtual with reality. Blue Hat creates a rich visual and interactive environment for users through the integration of real objects and virtual scenery. This combination provides users with a more natural form of human computer interaction, enhances a user’s perception of reality, and delivers a more immersive entertainment experience.

Proprietary Technology

Founded in 2010, Blue Hat’s proprietary technology, product research and development, marketing channels and brand operation are the cornerstones of the business. Blue Hat focuses on the combination of “online” and “offline” activity and the interaction between “entertainment” and “product” to create a high-tech entertainment platform combining mobile games and AR. With the help of computer graphics, motion capture technology, image recognition technology and visualization technologies, Blue Hat accurately “places” virtual objects into the physical world, creating a new and stimulating visual environment for users.

Blue Hat recently displayed a variety of its sci-tech products at the Guangzhou International Toy Exhibition in China including AR Racer, Elastic Bubbles, AR Space Track, AR Alloy Toy Car, AR Need a Spanking, 5D Animated Magic Aquarium, Bug Travelers, AR Picture Book and other interactive games and smart toys.

The company has multiple products in development including new generations of four primary product lines and two new product lines.

Patents and Copyrights

Blue Hat’s advanced AR technology in interactive entertainment is protected by 178 authorized patents with 44 patents in various stages of the application process.

Another 14 applications for Patent Cooperation Treaty, or PCT, have been filed for international patents. As of March 31, 2019, the company owns 645 copyrights for artwork, 71 registered trademarks and 27 software copyrights.

Sales and Marketing

There has been rapid growth in the toys and games industry in China over the last several years. Total retail sales of toys and games in China soared from RMB 111.8 billion in 2012 to RMB 276.5 billion in 2017 with an average annual growth rate of 19.9% in 2017. Blue Hat believes the company is well positioned with little competition as the toy industry rapidly shifts toward intelligent and interactive toys and games. Retail sales of electronic toys grew at 24% annually in 2017 while that of traditional toys grew at 7%.

In addition to a powerful ecommerce presence, Blue Hat has long-term relationships with partnered distributors that place the company’s AR interactive entertainment products into well-known international retail chains and retail outlets. Blue Hat’s integrated online and offline sales channels include e-commerce giants such as Amazon and Alibaba, retail chain stores and the company’s physical experience store located in Xiamen, China. Blue Hat plans to open or franchise approximately 100 additional stores in China by 2021.

Blue Hat’s community-based platform offers users a highly engaged and interactive community with online communication forums and offline social activities. The company advocates a new model of “teaching through lively activities” and combines AR technology with education, integrating its products into situational teaching, roleplaying and man-machine interaction. This novel educational experience helps realize optimal transformation of information, creating a knowledge and enhancing cognition.

Management

Director and CEO Xiaodong (Sean) Chen has over 20 years of experience creating, developing and producing toys and games related products. Chen earned his EMBA from Renmin University of China and has been chairman of the board of directors and general manager of Fujian Blue Hat Interactive Entertainment Technology Ltd. since August 2015.

CFO and Director Caifan, who has over 20 years of financial accounting and taxation experience, earned a degree in finance from Hunan University of Finance and Economics. He has served as director, deputy general manager and financial controller of Fujian Blue Hat Interactive Entertainment Technology Ltd. since August 2015.

Jianyong Cai, chief technology officer and director, has over 35 years of experience in data communication principles, communication network foundation, software engineering, communication network theory and technology and computer network architecture. He holds degrees in data communication principles, communication network foundation and software engineering from University of Science and Technology of China. He has been director, deputy general manager and chief engineer of Fujian Blue Hat Interactive Entertainment Technology Ltd. since January 2010.

For more information, visit the company’s website at www.BlueHatGroup.net

NOTE TO INVESTORS: The latest news and updates relating to BHAT are available in the company’s newsroom at http://ibn.fm/BHAT