Cannabis enthusiasts, investors, decision-makers, and business owners, are invited to attend the 420 Expo 2023 to be held in New Jersey Expo Center, Edison, NJ from September 29 – October 1, 2023. The electrifying event is set to blaze the ever-evolving cannabis landscape, including medical experts discussing the therapeutic potential of cannabis and professionals sharing their success stories.

420 Expo 2023 is a one-of-a-kind gathering that celebrates the world of cannabis culture, from its insightful medical applications to its important role in mainstream culture. Featuring the legendary Cheech Marin as a special guest host, the dynamic cannabis convergence promises to deliver the creative side of cannabis culture. The iconic figure will be meeting fans for photos and autographs along with about a dozen other marijuana-relevant celebrities, infusing the convention with an exclusive blend of pop culture.

Innovating the Cannabis Community

The 420 Expo 2023 will serve as a knowledge goldmine with some of the most prominent experts in the cannabis industry delivering engaging talks and panel discussions. Hosted at the New Jersey Expo Center, the convention is renowned for its advanced cannabis policies. The event will feature live performances and cannabis-inspired art from entertainers who’ve made cannabis an integral part of their culture. As a dynamic union of everything cannabis, the expo promises to promote innovation, education, community and healing.

The expo aims to leave participants inspired, informed, and equipped with a deeper understanding of the cannabis landscape. It features dedicated outdoor smoking areas with food trucks, over 100 vendors, celebrity appearances, live music, stage performances, panel discussions, educational seminars, a full VIP program, and nightly VIP after-parties. Interested participants should register for the 420 Expo 2023 now. Don’t miss out on the largest cannabis event of the year.

To learn more, please visit https://ibn.fm/w6sEz.

• For Q2 2023 ended June 30, Near reported revenue of $17.7 million, up 19% over Q2 2022
• For the same 2023 period, the company reported GAAP gross profit of $12.1 million
• Near’s GAAP gross margin for Q2 2023 was 68%
• The company’s Q3 2023 guidance forecasts total revenue in the range of $18 million to $20 million
• Near holds 10 patents globally and has a multiyear head start on gathering unique data points

Near Intelligence (NASDAQ: NIR), a Privacy-Safe Geospatial Intelligence Platform, curates one of the world’s largest sources of intelligence on people and places. Near’s patented technology analyzes data to deliver insights on approximately 1.6 billion unique user IDs across 70 million points of interest in more than 44 countries. With Near’s three-pillared approach – high-quality data, privacy, and AI – operational and marketing leaders are empowered with solutions to successfully engage and grow their businesses at scale. With a presence in Pasadena, San Francisco, Paris, Bangalore, Singapore, Sydney, and Tokyo, Near serves enterprises in diverse industries, including retail, real estate, restaurants, travel/tourism, telecom, media, and more.

Established in 2012, Near employs vast data volumes to comprehend consumer behavior across digital and physical realms, ensuring privacy compliance through anonymization and aggregation. The company analyzes behavior around visited places and connected devices.

Near is headquartered in Pasadena, California.

Platform and Services

The Near platform delivers global, high-quality data in a privacy-safe environment, evaluating consumer activity across physical and digital spaces to provide business leaders with deep insights into the places their customers frequent, along with their brand and competitor preferences.
It is built on three fundamental tenets:

• Global, High-Quality Data: The Near Platform provides high-quality insights about people and places from diverse industries and applications. Through complex data refinement processes, Near converts raw data into powerful insights that empower decision-makers with actionable information.
• Privacy and Transparency: Data privacy and transparency are deeply ingrained in Near’s foundation. The platform is built on the principle of privacy by design, ensuring that data privacy considerations are integrated into every aspect of its products, processes, and practices. The Near approach empowers business decision-makers with control over their information and adheres to the most stringent global privacy regulations.
• Data Science and AI Innovation: The Near Platform employs advanced algorithms and machine learning models to deliver high-quality insights, so users can decipher complex consumer behavior patterns and trends.

In August 2023, Near illustrated the value of its intelligence platform in one such industry – quick-service restaurants (“QSRs”). Many of the world’s largest QSR brands count Near as a trusted partner for high-quality data insights and restaurant analytics. By harnessing Near’s advanced analytics capabilities, top QSRs with combined annual revenues approaching $90B are able to understand consumer movement and behavior patterns, brand affinities, trade areas, and trends.

The company also collaborates with partners to strengthen their datasets by integrating Near’s physical and digital world understanding. Near’s data is always delivered with a privacy-first, consent-led approach via its SaaS-based geospatial analytics platform.

Market Outlook

An analysis from Fortune Business Insights estimated the global business intelligence market was valued at $27.11 billion in 2022 and is projected to grow from $29.42 billion in 2023 to $54.27 billion by 2030, a CAGR of 9.1% during the forecast period.

According to the report, global market growth can be attributed to the increasing adoption of cloud-based Artificial Intelligence/Machine Learning services and data analytics across organizations. A surge in demand for flexible architectures and adaptable solutions opens up market expansion opportunities.

Management Team

Anil Mathews is the CEO of Near. He is a visionary who has spent the past 22 years as a serial entrepreneur, building successful businesses around engineering, messaging, and social. He is passionate about creating new market companies with a strategic vision and technology capability that can provide substantial growth. He is also an advisor and investor to numerous startups across the globe.

Shobhit Shukla is President of Near. He currently runs the company’s global business and strategic initiatives, where he is responsible for executing Near’s vision to become the most accurate and privacy-safe source of intelligence on people and places. He holds an MBA from the Indian Institute of Management and advises multiple early-stage startups on growth strategy.

Gladys Kong is COO of Near. She was previously CEO of UberMedia, a data intelligence company acquired by Near. She was also CEO of Go Interactive, a fantasy sports company. Before that, she held Engineering and R&D vice president positions at Snap.com and Idea Lab. She has a bachelor’s degree in engineering and applied science from Caltech and a master’s degree in computer science from UCLA.

Rahul Agarwal is the CFO of Near. He began his career at PwC India and later held accounting and finance roles at HT Media and InMobi, where he rose to the position of Head of Finance, North America. He is a graduate of The Institute of Chartered Accountants of India and holds an MBA in finance and strategy from the Indian Institute of Management at Bangalore.

For more information, visit the company’s website at www.Near.com.

NOTE TO INVESTORS: The latest news and updates relating to NIR are available in the company’s newsroom at https://ibn.fm/NIR

• USGS reports that tellurium’s primary use is for manufacturing films essential to photovoltaic solar cells
• Most tellurium is indirectly mined because it is a byproduct of milled copper, iron and other base-metal-rich ore bodies
• First Tellurium is exploring, developing tellurium projects, confident that demand for tellurium will increase

Calling tellurium “the bright future of solar energy,” the U.S. Geological Survey (“USGS”) has prepared a report about the rare metal as part of its mission to conduct research and provide information about nonfuel mineral resources (https://ibn.fm/TdWoi). As a company committed to exploring and providing green and critical metals, First Tellurium (CSE: FTEL) (OTCQB: FSTTF) is strengthening its position in that bright future.

One of the least common elements on earth, tellurium is primarily used “for manufacturing films essential to photovoltaic solar cells,” reports the USGS. “When alloyed with other elements — such as cadmium — tellurium forms a compound that exhibits enhanced electrical conductivity. Therefore, a thin film can efficiently absorb sunlight and convert it into electricity. As an additive to steel, copper, and lead alloys, tellurium improves machine efficiency, specifically in thermoelectric cooling applications where it improves ductility and tensile strength, and helps prevent sulfuric acid corrosion. Together, the photovoltaic and thermoelectric applications account for more than two-thirds of global tellurium consumption.”

The report also noted that tellurium is used in copying machines, as a coloring agent in ceramics and glass, and as a vulcanizing agent in the chemical industry to make durable products, including an additive that improves rubber’s heat resistance.

Most tellurium used today is indirectly mined, the USGS article noted, because it is recovered as a byproduct of milled copper, iron and other base-metal-rich ore bodies containing trace amounts of tellurium-bearing minerals. “Globally, primary tellurium sources are large-tonnage, low-grade ores from copper and copper-gold porphyry-type deposits, as a byproduct of copper refining,” stated the report, which also explained that tellurium is concentrated in discreet telluride minerals and the structures of sulfide minerals in most gold deposits.

First Tellurium is exploring and developing tellurium projects in British Columbia and Colorado, confident that as the world focuses on developing green technologies, the demand for tellurium will only increase. “We’ve built a bold new approach to mineral exploration,” the company states (https://ibn.fm/XzUbw). “Our model is to generate revenue and investor value through mineral discovery, project development and cooperative access to untapped mineral regions with sustainable exploration and strong, mutually beneficial engagement with Indigenous communities.”

First Tellurium’s polymetallic (tellurium, gold, silver, copper, tungsten) Deer Horn Project in British Columbia and Klondike tellurium-gold property in Colorado anchor a diversified search for metals, working in alliance with Indigenous peoples, NGOs, governments and leading metals buyers.

For more information, visit the company’s website at www.FirstTellurium.com.

NOTE TO INVESTORS: The latest news and updates relating to FSTTF are available in the company’s newsroom at https://ibn.fm/FSTTF

• Eloro Resources recently provided an update on the company’s ongoing exploratory drill work
• Recent findings revealed a number of holes with well-mineralized intersections, suggesting both – robust mineralization trends as well as an ever-widening prospective target area
• Global tin demand is set to grow by nearly a third over the next 8 years, however, the supply growth picture is looking increasingly tenuous
• Eloro Resources looks well positioned to capitalize from the ongoing growth in demand for the commodity, with the company having published its inaugural MRE report at the end of August

Eloro Resources (TSX: ELO) (OTCQX: ELRRF) (FSE: P2QM), an exploration and mining company focused on developing its potential world-class Iska Iska silver-tin polymetallic property located in the Potosi Department in southern Bolivia, recently updated the market with updated assay results derived from the company’s ongoing reconnaissance drilling. Recent drilling work across 16 holes, spread across Eloro’s Mina Casiterita Property, Santa Barbara deposit and Porco-Mine 1 area, uncovered an array of well-mineralized intersections. Moreover and with tin mineralization at Casiterita revealed in deposits up to 2km southwest of the Santa Barbara deposit, findings suggest that Iska Iska’s cumulative mineral deposits may be far more extensive than previously anticipated (https://ibn.fm/jXvtt).

Tom Larsen, CEO of Eloro, said: “We are encouraged by the initial drilling results from Mina Casiterita, especially considering the reconnaissance nature of the drill program. The grade and width intersected in hole DCT-03, considering the recently reported positive “ore-sorting” results, is attractive, particularly with the higher-grade sections.”

The global march towards Net Zero, an ambition predicated on the world achieving a balance between global greenhouse gas (“GHG”) emissions and those being removed from the atmosphere by 2050, has now emerged as the biggest long-term demand driver of tin. In fact, a recent report by Reportlinker.com suggests that the global market could reach a revised size of 481.9 thousand tons by 2030, up from 338.5 thousand tons of demand in 2022 (https://ibn.fm/UJaVw). However, the commodity faces an increasingly tenuous supply backdrop. Over 50 percent of the global tin supply originates from China and Indonesia; meanwhile, Myanmar and the Democratic Republic of Congo play key roles within the commodity’s global supply chain.

The United States’ landmark Inflation Reduction Act (“IRA”), launched in August 2022, has dramatically changed the rules for global clean energy supply chains. The act, which seeks to incentivize the ongoing adoption of clean energy technologies and electric vehicles in the United States through the provision of generous subsidies, requires that 80% of an EV battery’s critical minerals should be sourced either domestically or from free trade countries (“FTCs”) by 2027 (https://ibn.fm/k6HMf). Crucially – that excludes raw materials and minerals sourced from the likes of China, Myanmar and the Democratic Republic of Congo, instantly making nearly 45% of the globe’s tin supply ineligible for inclusion into US-bound clean technology products (https://ibn.fm/dFwdW).

Eloro Resources’ ongoing efforts to play a role in bridging the widening supply gap within the global tin supply chain looks positively poised, particularly post the company’s recent positive drilling results. Dr. Bill Peasron, Eloro’s Executive Vice President of Exploration elaborated on the company’s next steps, including confirming the timeline for the release of Eloro’s inaugural NI 43-101 compliant mineral resource estimate.

“The inaugural mineral resource is near completion and is expected to be released by the end of August. Following completion of the [the company’s] recent $6.9 million bought deal financing, the planned next phase of work at Iska Iska has begun. The work plan consists of an initial 5,600m of definition drilling at Santa Barbara to better define higher-grade areas in the shallower parts of the potential pit to enhance earlier payback; drilling of four PQ metallurgical holes totaling 1,250m for further metallurgical tests including “ore-sorting”; and preparation of a PEA (preliminary economic assessment), including required site work, on the Santa Barbara deposit.”

For more information, visit the company’s website at www.EloroResources.com.

NOTE TO INVESTORS: The latest news and updates relating to ELRRF are available in the company’s newsroom at https://ibn.fm/ELRRF

• Lexaria’s IND application for its U.S. Phase 1b Hypertension Clinical Study, HYPER-H23-1, remains on track despite setbacks
• Work mostly under Lexaria’s control was completed earlier this year, while work that is outside its control remains delayed
• Regardless, Lexaria continues to make progress, even as it looks to take advantage of the growing global cardiovascular drugs market, which is projected to post a CAGR of 3.1% between 2021 and 2026
• Chris Bunka, Lexaria’s CEO, has lauded the company’s exceptional discovery, which demonstrates the ability of the patented DehydraTECH-processed CBD to lower blood pressure in the patient population

Lexaria Bioscience (NASDAQ: LEXX), a global innovator in drug delivery platforms, remains on track for its upcoming submission of an Investigational New Drug (“IND”) application for its planned U.S. Phase 1b Hypertension Clinical Trial, dubbed HYPER-H23-1. The study, entitled “A Phase 1b Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Pharmacokinetics, and Pharmacodynamics of DehydraTECH-CBD in Subjects with Stage 1 or Stage 2 Hypertension,” looks to evaluate the safety and tolerability of Lexaria’s patented DehydraTECH(TM)-processed CBD in hypertensive patients (https://ibn.fm/JTESt).

This study builds on five previous human clinical studies conducted from 2018 to 2022, which will be integral to the successful filing and review of the planned IND submission. Most notably, the studies, which involved 134 healthy and hypertensive persons, evidenced significant reductions in resting blood pressure over both acute and multi-week dosing regimens. In addition, the studies also showed zero serious adverse events, evidencing DehydraTECH-CBD’s potential to have pronounced clinical benefits relative to available anti-hypertensive therapeutics.

Work that is mainly under Lexaria’s control was completed earlier this year. This included batch manufacturing of DehydraTECH-CBD and placebo materials necessary for the application. However, work outside of Lexaria’s control remains delayed. This includes the provision of required documentation by a materials supplier and stability testing of the material. As such, Lexaria cannot yet submit the IND package to the FDA until the delays have been addressed, although progress is still being made.

In 2021, the global cardiovascular drugs market was estimated at $146.51 billion. By 2026, the market is expected to be valued at $173.48 billion, posting a CAGR of 3.1% (https://ibn.fm/u7ToC). Lexaria looks to capitalize on this growth while carving a decent market share. The IND application with the FDA will be integral to the company realizing this goal and bringing relief to the many people living with cardiovascular conditions.

“That we were able to lower blood pressure in our patient population over multiple weeks using DehydraTECH-CBD is an exceptional discovery, given that previous studies by others using other oral CBD formulations have failed to evidence this sustained benefit,” noted Chris Bunka, Lexaria’s CEO (https://ibn.fm/uiKph).

So far, Lexaria is aware of only a handful of other published research studies that have investigated whether a sustained decrease in resting blood pressure is possible following multiple weeks of oral CBD dosing. However, it notes that none have succeeded in achieving this, proving DehydraTECH-CBD’s superior power to reduce blood pressure over other oral CBD formulations.

For more information, visit the company’s website at www.LexariaBioscience.com.

NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://ibn.fm/LEXX

• Longeveron management will present at the 25th Annual H.C. Wainwright Global Investment Conference scheduled for September 11-13, 2023, in New York
• Wa’el Hashad, the company’s CEO, will discuss Longeveron’s cellular therapy programs in a pre-recorded presentation. Both he and Lisa Locklear, EVP & Chief Financial Officer, will be at the conference to discuss the company’s investment strategies and clinical trial progress
• The company aims to create awareness among scientists and investors of its clinical trial progress, positive clinical results, and cellular therapy programs
• Longeveron is evaluating its lead investigational product candidate, a cellular product named Lomecel-B(TM), in ongoing clinical trials
• The product candidate is being advanced as a potential treatment for hypoplastic left heart syndrome (“HLHS”), Aging-related Frailty, and Alzheimer’s disease

Longeveron (NASDAQ: LGVN), a clinical-stage company, is focused on developing cellular therapy primarily for conditions with a clear unmet medical need. The company is guided by the mission to advance cell-based product candidates into pivotal Phase 3 trials, with the goal of attaining regulatory approvals and subsequently commercializing the product.

Longeveron has so far made significant strides in line with this mission, progress that the company’s management will share during the 25th Annual H.C. Wainwright Global Investment Conference scheduled for September 11-13, 2023, in New York. On his part, Wa’el Hashad, the company’s CEO, will discuss Longeveron’s cellular therapy programs in a pre-recorded presentation. Both he and Lisa Locklear, Longeveron’s EVP & Chief Financial Officer, will attend the conference in person to discuss the company’s investment strategies and clinical trial progress (https://ibn.fm/99cEG).

The programs and clinical trials are currently anchored in the company’s lead investigational therapeutic candidate, a cellular therapy called Lomecel-B(TM). Lomecel-B is derived from culture-expanded medicinal signaling cells (“MSCs”) isolated from the bone marrow of healthy young adult donors (https://ibn.fm/sYprw). The drug candidate is undergoing evaluation – as part of three separate Phase 2 clinical trials – as a potential treatment for three indications: hypoplastic left heart syndrome (“HLHS”), Aging-related Frailty, and Alzheimer’s disease.

HLHS is a rare congenital heart condition that affects about 1,000 newborns every year in the United States. HLHS patients are born with a severely underdeveloped left ventricle, which is normally responsible for pumping oxygenated blood to the body. The condition is fatal shortly after birth if left untreated. Thus, to avert certain death, the babies undergo three heart surgeries (Stage I, Stage II, and Stage III), staggered over several years, which convert the heart into a functioning 3-chamber heart (instead of a normal 4-chamber heart).  In the reconstructed heart, and after the Stage III surgery, the right ventricle entirely takes over the role of pumping oxygenated blood to the body.

Unfortunately, despite these efforts, HLHS babies still have high mortality and morbidity and often still require a heart transplant, mainly due to heart failure. The mortality risk for children with hypoplastic left heart syndrome is highest in the first year of life. For this reason, Longeveron is evaluating Lomecel-B’s potential to improve cardiac function when administered directly to the myocardium (heart muscles) at the time of Stage II surgery. The company completed its safety-focused open-label Phase 1 (“ELPIS I”) study evaluating Lomecel-B(TM) for the treatment of HLHS, reporting positive clinical results.

When cardiac surgeons injected the product directly into the babies’ hearts, the MSCs were well tolerated, with no significant adverse cardiac events and no infections related to the investigational treatment reported. Moreover, the study results showed a 100% survival rate up to 5 years after treatment, with no need for heart transplant, for the ten infants enrolled in the study. By comparison, historical data indicates an approximate 20% mortality rate over the same period of time (see “Other References” below).

The positive Phase 1 data led to the  U.S. Food and Drug Administration (“FDA”) granting  Rare Pediatric Disease Designation (“RPDD”) (https://ibn.fm/RVvzm), Orphan Drug Designation (“ODD”) (https://ibn.fm/W6ebo), and Fast Track Designation (“FTD”) (https://ibn.fm/uAPT7) for Lomecel-B(TM) for the treatment of HLHS.

Lomecel-B(TM) is currently being evaluated in a Phase 2 clinical trial (“ELPIS II”). A multicenter, randomized, double-blind, controlled clinical trial, ELPIS II is designed to evaluate Lomecel-B(TM) as an adjunct therapy to the standard-of-care Stage II HLHS heart reconstructive surgery. The primary endpoint is to assess whether the treatment improves heart function and improves survival compared to standard-of-care surgery alone. The trial has enrolled more than 50% of the 38 targeted subjects.

Longeveron is also conducting a Phase 2a trial (“CLEAR MIND”) to evaluate multiple doses of Lomecel-B(TM) in patients with mild Alzheimer’s disease. The primary objective of the trial is the safety and tolerability of single and multiple doses of Lomecel-B in patients with mild AD. The study will also evaluate the efficacy of single and multiple doses of Lomecel-B on disease progression in patients with mild Alzheimer’s disease. Longeveron expects the topline data results in October 2023.

Moreover, Longeveron has completed two studies (Phase 2b and a Phase 1/2a trial) in the United States. for the treatment of Aging-related Frailty. The company has also received regulatory approval in Japan, permitting an investigator-sponsored Phase 2 clinical trial for Aging-related Frailty. The Japan clinical trial is ongoing. Aging-related Frailty is a life-threatening geriatric condition that increases the risk of poor clinical outcomes from injury and disease. It does not have an approved treatment, representing an untapped opportunity for Longeveron. The company aims to work with regulatory agencies to advance Lomecel-B(TM) as potentially the first approved drug for Aging-related Frailty.

Looking ahead, Longeveron is looking to create awareness of these cellular therapy programs, the progress made with its clinical trials, and accompanying positive clinical data at conferences and scientific sessions. The upcoming investment conference provides an ideal setting as it brings together investors from all over the world.

For more information, visit the company’s website at www.Longeveron.com. 

Other References:

1. Newburger et al. Circulation (2018) 137:2246-2253
2. Newburger et al. Circulation (2014) 129:2013-2020
3. Ohye et al. N Engl J Med (2010) 362:1980-1992

Forward-Looking Statements

Certain statements in this article that are not historical facts are forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, which reflect management’s current expectations, assumptions, and estimates of future operations, performance and economic conditions, and involve risks and uncertainties that could cause actual results to differ materially from those anticipated by the statements made herein. Forward-looking statements are generally identifiable by the use of forward-looking terminology such as “believe,” “expects,” “may,” “looks to,” “will,” “should,” “plan,” “intend,” “on condition,” “target,” “see,” “potential,” “estimates,” “preliminary,” or “anticipates” or the negative thereof or comparable terminology, or by discussion of strategy or goals or other future events, circumstances, or effects. Factors that could cause actual results to differ materially from those expressed or implied in any forward-looking statements in this release include, but are not limited to, statements regarding the offer and sale of securities, the terms of the offering, about the ability of Longeveron’s clinical trials to demonstrate safety and efficacy of the company’s product candidates, and other positive results; the timing and focus of the company’s ongoing and future preclinical studies and clinical trials and the reporting of data from those studies and trials; the size of the market opportunity for the company’s product candidates, including its estimates of the number of patients who suffer from the diseases being targeted; the success of competing therapies that are or may become available; the beneficial characteristics, safety, efficacy and therapeutic effects of the company’s product candidates; the company’s ability to obtain and maintain regulatory approval of its product candidates in the U.S., Japan and other jurisdictions; the company’s plans relating to the further development of its product candidates, including additional disease states or indications it may pursue; the company’s plans and ability to obtain or protect intellectual property rights, including extensions of existing patent terms where available and its ability to avoid infringing the intellectual property rights of others; the need to hire additional personnel and the company’s ability to attract and retain such personnel; the company’s estimates regarding expenses, future revenue, capital requirements and needs for additional financing; the company’s need to raise additional capital, and the difficulties it may face in obtaining access to capital, and the dilutive impact it may have on its investors; the company’s financial performance and ability to continue as a going concern, and the period over which it estimates its existing cash and cash equivalents will be sufficient to fund its future operating expenses and capital expenditure requirements. Additionally, Longeveron makes no assurance that any public offering of its securities as described herein will occur on the timelines, in the manner or on the terms anticipated due to numerous factors. Further information relating to factors that may impact the company’s results and forward-looking statements are disclosed in the company’s filings with the Securities and Exchange Commission, including Longeveron’s Annual Report on Form 10-K for the year ended December 31, 2022, filed with the Securities and Exchange Commission on March 14, 2023 and its Quarterly Report on Form 10-Q for the second quarter of 2023 filed with the SEC on August 11, 2023. The forward-looking statements contained in this article are made as of the date of this article, and the company disclaims any intention or obligation, other than imposed by law, to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.

Investor Contact
Mike Moyer
LifeSci Advisors
Tel: 617-308-4306
Email: mmoyer@lifesciadvisors.com

For more information, visit the company’s website at www.Longeveron.com.

NOTE TO INVESTORS: The latest news and updates relating to LGVN are available in the company’s newsroom at http://ibn.fm/LGVN

• U.S.-based generic drug developer SOHM recently announced the addition of two leading officers — Dr. David Aguilar (Ph.D) as Chief Operating Officer and Dr. Krishna Bhat (MD, Ph.D, FACC) as Chief Medical Advisor
• The new officers are expected to help direct SOHM’s global growth strategy as the company continues to develop and diversify its product offerings, which include a variety of mediums for administering antibiotics, analgesics, anti-inflammatory and anti-cold therapies, as well as vitamins
• SOHM also recently announced an LOI to acquire a stem cell disruptive technology and related patents, which include the potential for someday treating damaged hearts via gene editing
• The company’s global operation is primarily focused on emerging markets in Africa, Latin America, and Southeast Asia

Generic drug manufacturing and distributing innovator SOHM (OTC: SHMN) is strengthening its governing team with the addition of two experienced visionaries committed to helping the company’s growth in the pharmaceutical, nutraceutical, and cosmeceutical marketplace.

Dr. Krishna Bhat (MD, Ph.D, FACC), an experienced bioscientist and cardiologist, will bring his leadership skills to the company’s advisory board as its new Chief Medical Advisor, increasing his commitment beyond his involvement as a longtime shareholder, according to an announcement Aug. 24.

“Dr. Bhat brings valuable experience and expertise in the field of cardiology, which will support our planned acquisition of ABBIE Technology and its innovative patents, clinical trials, diagnostic kits and cardiac treatments,” SOHM president and CEO Baron Night stated in the news release (https://ibn.fm/ZNXX2). “Dr. Bhat is a renowned Clinical and Interventional Cardiologist who has authored over 16 medical scientific publications. We look forward to benefiting from his insights and guidance for our current and future pipelines.”

Earlier in August, SOHM signed a letter of intent to acquire “ABBIE” (A Binding Based Integrating Enzyme) stem cell disruptive technology and patents from CGA Intellectual Holdings Inc. to create novel products and solutions in the regenerative medicine and cosmeceutical industries, with initial development focused on “optimization of targeting and understanding limitations of the ‘payload’ size that can be utilized to deliver the gene(s) of interest” (https://ibn.fm/25YWT).

The ABBIE platform is still in early stages of research and development, but it has already shown promising results through gene editing in animal and human cells in vitro and is expected to provide significant solutions for cardiac patients by offering cell therapies to repair damaged hearts (https://ibn.fm/2cR9S).

SOHM also recently announced the appointment of Dr. David Aguilar (Ph.D) as Chief Operating Officer to direct the company’s sustainability, stability, growth and new developments at its uppermost level, drawing on his 22 years of experience in the pharmaceutical industry working with clinical and regulatory needs for preclinical and IND filings of allogeneic cell-based therapies.

“We are delighted and fortunate to have someone with Dr. David Aguilar’s talent, business acumen and deep institutional knowledge of SOHM, Inc. oversee these functions and manage our global businesses,” Night stated in the Aug. 8 announcement (https://ibn.fm/cCzUz).

SOHM is headquartered in California and exports its products around the world, focusing on emerging markets in Africa, Latin America and Southeast Asia. The company uses manufacturing alliances in India and strategic alliances with U.S. manufacturing facilities to develop its product line, which includes antibiotics, analgesics, anti-inflammatory and anti-cold therapies, and vitamins.

For more information, visit the company’s website at www.SOHM.com.

NOTE TO INVESTORS: The latest news and updates relating to SHMN are available in the company’s newsroom at https://ibn.fm/SHMN

• PaxMedica recently announced positive top line results from its PAX-101 Phase 3 African Sleeping Sickness Study, paving the way for an expected New Drug Application filing in 2024
• The company granted exclusive pharmacy distribution for PAX-101 to Vox Nova LLC, the first purpose-built limited distribution specialty pharmacy benefit manager for people with ASD
• PaxMedica submitted PAX-101 Clinical Trial Request to the South African Health Products Regulatory Authority, requesting approval for a double-blind, placebo-controlled study in ASD
• The company entered a Research Collaboration Agreement with PoloMar Health and The BRAIN Foundation for a Phase II proof-of-concept trial in ASD

PaxMedica (NASDAQ: PXMD) is a clinical stage biopharmaceutical company focusing on the development of novel anti-purinergic therapies (“APTs”) for the treatment of Autism Spectrum Disorder (“ASD”) and other serious conditions with intractable neurologic symptoms.

The company’s lead programs are focused on ASD, for which there are currently no approved pharmacologic treatments that target its cause and symptoms. Currently used treatments only address the symptoms of the condition, rather than targeting the pathophysiology itself.

PaxMedica is on a promising path to address these unmet medical needs, bringing hope to millions. Anti-purinergic therapies target the excess production of purines in cells. An overexpression of purines can offset homeostasis and result in an overproduction of cellular adenosine triphosphate, the main energy molecule in all living cells.

The company is headquartered in Tarrytown, New York.

Product Pipeline

PaxMedica is building a robust pipeline of products targeting ASD and related neurodevelopmental conditions. The company’s lead product in development may help eliminate, reduce or modulate some of the more troublesome aspects of ASD. That would open the potential for people with autism to integrate their behavior with others more successfully and improve their lives.

PaxMedica’s lead programs, PAX-101 and PAX-102, utilize the company’s proprietary source of suramin sodium, a broadly acting anti-purinergic therapy that has been known for over 100 years. Its current pipeline includes:

• PAX-101 (IV Suramin) for ASD – PAX-101 completed a Phase 2B study for ASD in 2021. Suramin is a broadly acting APT and has reported positive results from a dose range study. The results of PaxMedica’s Phase 2B study, which targeted 52 subjects across six sites in South Africa, were presented to AACAP in October 2021.
• PAX-102 (Intranasal Suramin) – PaxMedica has developed a proprietary intranasal formulation of suramin that is currently being evaluated in ASD and other neurodevelopmental conditions.
• PAX-101 for HAT – Given suramin’s historical use as a treatment for Human African Trypanosomiasis (“HAT”), or African Sleeping Sickness, the company is also developing PAX-101 as a treatment for HAT. PaxMedica’s most advanced program is the pursuit of PAX-101 for early-stage East African HAT.
• Selective APTs – PaxMedica has conducted several preclinical studies to evaluate other APTs that are more selective to specific purinergic receptors and may offer additional benefits over suramin.

Market Opportunity

According to a report by Fortune Business Insights, a leading global market research company, the global ASD therapeutics market was estimated at $1.93 billion in 2022 and is projected to grow from $2.01 billion in 2023 to $3.42 billion by 2030, a CAGR of 7.9% over the forecast period. As there is no current treatment for the core symptoms of autism, PaxMedica believes the addressable market for PAX-101, if approved, could greatly exceed these forecasts.

Autistic disorder, Asperger’s Syndrome and Pervasive Development Disorder are the three main types of ASD, affecting millions of people globally. A 2020 report by the U.S. Centers for Disease Control & Prevention estimated that one in 36 children in the U.S. have been diagnosed with autism disorder.

Several factors are expected to contribute to market growth prospects. A growing prevalence of the condition globally and rising awareness coupled with available treatment options are key factors expected to drive ASD therapeutics market growth during the forecast period. Growing investment in R&D to find effective treatments is also expected to fuel global market growth.

Management Team

Howard Weisman is Chairman and CEO of PaxMedica. He has been a founder and CEO of several specialty pharma and medical device companies. Most recently, he was executive chairman and co-founder of Sofregen, a biotech company. He also served as CEO and president of Seventh Sense Biosystems, a medical device development company. He also was founder, chairman and CEO of EKR Therapeutics, a specialty pharmaceutical company, and founder and COO of ESP Pharma, a company focused on cardio and neurovascular products. He has a bachelor’s degree in chemistry from Rutgers University.

David Hough, M.D., is Chief Medical Officer at PaxMedica. He is a neuroscience clinical development consultant who previously served as vice president at Janssen Research and Development and in various leadership roles over 17 years. Most recently, he was the compound development team leader for SPRAVATO(R) for treatment-resistant depression. Prior to that, he was the schizophrenia disease area leader. He played a pivotal role in the development programs for oral INVEGA(R), INVEGA SUSTENNA(R) and XEPLION(R) for schizophrenia. He is a graduate of West Point and is board certified in psychiatry.

Stephen Sheldon is COO and CFO at PaxMedica. He has served as CEO of Thailand-based specialty healthcare company Indochina Healthcare Co. Ltd. since 2015. Previously, he was a consultant for PricewaterhouseCoopers Healthcare Advisory in the Chicago office. He was responsible for developing specialty pharmacy patient programs, strategy development for specialty products and compliance programs. He has an MBA from Thunderbird School of Global Management and a bachelor’s degree in computer science and visual arts from Bowdoin College.

For more information, visit the company’s website at www.PaxMedica.com.

NOTE TO INVESTORS: The latest news and updates relating to PXMD are available in the company’s newsroom at https://ibn.fm/PXMD

• RJDG acquires and manages assets in three diverse markets: construction, digital healthcare services, and environmental solutions
• Asset portfolio includes Silex Interiors, ioSoft Inc., and Earthlinc Environmental Solutions
• Silex Interiors manufactures, distributes, and installs bathroom and kitchen furniture, countertops, and related products; awarded contract that is expected to generate $850,000+ revenue in 2023
• ioSoft Inc. provides secure payment technologies, cloud-based software, and professional services to healthcare industry; recently procured software development and IT support contract to customize ioSoft Suites for the RailPro Group
• Earthlinc Environmental Solutions offers patented waste processing technology for commercial chicken and hog farms; transforms waste into animal feed while recycling the water for reuse on the farm

Diversification is critical to investment success for many reasons: stable returns, risk reduction, and protection against market volatility. With these principles in mind, RJD Green (OTC: RJDG) a holding company, manages assets in three diverse, high-growth industries in separate “recession-resistant” markets, including construction, digital healthcare services, and environmental solutions.

RJDG formed its specialty construction division to focus on industrial contracting, building material products, and construction services. The company’s first acquisition, Silex Interiors, is a manufacturer, distributor, and installer of countertops, cabinets, and related bathroom and kitchen products with a large target market comprising commercial contractors, residential builders, new and renovation contractors, and retail customers. With the aim of filling a market niche between “big box” stores and smaller retail distributors, RJDG plans to launch Silex into major national markets through internal expansion, franchising, and supplementary acquisitions.

Silex was awarded a large contract for natural stone countertops and cabinets in May 2023 that is expected to generate over $850,000 in revenue (https://ibn.fm/olu6H). “This significant commercial contract awarded to Silex continues the revenue progression in our commercial business segment and reflects geographic expansion,” said RJD Green CEO Ron Brewer. “The commercial contracts have helped offset the traditional seasonal revenue downturn that occurs in our home building sector and will contribute to revenue growth for the remainder of the year. These results reflect our continued implementation of our growth plan for Silex Holdings to expand market segments and broaden our customer base.”

ioSoft Inc., a software company under RJDG’s software division, provides secure payment technologies, cloud-based software, and professional services to healthcare payers and providers. The company’s SaaS offerings integrate seamlessly with legacy or existing systems, offering clients a flexible, scalable, cloud-based solution for managing medical billing, healthcare claims adjudication, and electronic payments.

RJD Green recently announced that ioSoft procured a software development and IT support contract for the RailPro Group, a consulting and marketing team focused on retail marketing and energy-related companies (https://ibn.fm/j7bNy). Under the agreement, ioSoft will customize the ioSoft Suite’s platform, including its ioSoft Unified Payment System(TM) and ioSoft LinkUp(TM) – a robust communication interface enabling users to view claim information, update enrollment, and access ID cards 24/7 from any connected device.

Earthlinc Environmental Solutions, part of RJDG’s environmental services division, provides North American companies with green solutions to ecological challenges. The company’s first acquisition, Animal Waste Management, offers patented waste processing technology for commercial chicken and hog farms. Developed with support from the University of Arkansas and the Missouri Department of Natural Resources, the technology transforms liquid, solid, and gas waste into clean, odorless, bacteria-free animal feed while recycling the water to be reused on the farm.

Based in Tulsa, Oklahoma, RJD Green Inc.’s management team leverages a successful track record in the public and private sectors, with extensive experience in each area of focus under its diverse divisions. The team expertly matches investments with projects to optimize growth, profitability, and shareholder returns.

For more information, visit the company’s website at www.RJDGreen.com.

NOTE TO INVESTORS: The latest news and updates relating to RJDG are available in the company’s newsroom at https://ibn.fm/RJDG

• D-Wave’s quantum solutions help businesses solve computationally complex optimization problems, including logistics, employee scheduling, factory processes, and more
• Advantage(TM) is D-Wave’s fifth-generation quantum computer featuring industry-leading 5,000+ qubits and 15-way qubit connectivity
• D-Wave’s commercial customers include blue-chip industry leaders like Mastercard, Deloitte, Siemens Healthineers, Unisys, NEC Corporation, Pattison Food Group Ltd., and Lockheed Martin

Business leaders today are faced with a myriad of solutions to consider for integration into their organization’s IT infrastructure, many of which are critical in achieving meaningful operational efficiency and business advantage. One of the most promising yet perplexing solutions is quantum computing. Most businesses are faced with a vast array of optimization problems, but solving those challenges efficiently can be incredibly challenging. D-Wave Quantum (NYSE: QBTS), a leader in quantum computing systems, software, and services, focuses on solving such challenges by delivering value to customers through practical quantum solutions for problems such as logistics, artificial intelligence, drug discovery, scheduling, and financial modeling.

As a leader in quantum computing, D-Wave has delivered the world’s first commercial quantum computer, the first real-time quantum cloud service, countless highly proprietary hardware and software products, and numerous scientific milestones. These innovations serve to help organizations harness the power of quantum technology to address their most computationally complex problems and to help business leaders recognize when to consider quantum over classical computing to tackle their biggest challenges.

Classical computers offer limited computation – using bits represented by 0s and 1s to store information. Quantum computers use quantum bits (qubits) to encode information as 0s and 1s with the ability to use them simultaneously. This superposition, along with other quantum mechanical phenomena and tunneling, enables quantum computers to manipulate enormous combinations all at once.

When using classical computers, business leaders are faced with the inability to search multiple avenues for solutions to complex problems – the solutions are often time-consuming and may never come to fruition. D-Wave’s quantum computer uses quantum annealing to search for solutions to these problems, with the goal of ultimately finding the best solutions without waiting weeks or months for an answer.

D-Wave’s current commercial quantum product offerings include:

• Advantage – a fifth-generation quantum computer featuring 15-way qubit connections and processor architecture with more than 5,000 qubits.
• Leap(TM) – the company’s quantum cloud service that allows developers proficient in Python to begin building and running quantum applications. Leap delivers immediate, real-time access to D-Wave’s Advantage quantum computer and hybrid solver services, with enterprise-class performance and scalability.
• Ocean(TM) – a suite of open-source Python tools that empower developers to experiment, rapidly develop, and harness the power of Advantage to solve complex problems.
• Launch(TM) – an onboarding solution that helps businesses get started on the quantum journey. Launch was designed to guide enterprises from problem discovery through in-production application deployment.

D-Wave’s commercial customers include blue-chip industry leaders like Volkswagen, Mastercard, Deloitte, ArcelorMittal, Siemens Healthineers, Unisys, Accenture, BBVA, NEC Corporation, Pattison Food Group Ltd., DENSO and Lockheed Martin. D-Wave features a diverse and robust collection of use cases on its Customer Success Stories page, showing how quantum computing has provided value in the real world (https://ibn.fm/ecL2y).

For more information, visit the company’s website at www.DWaveQuantum.com.

NOTE TO INVESTORS: The latest news and updates relating to QBTS are available in the company’s newsroom at https://ibn.fm/QBTS