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2050 Motors, Inc. (ETFM) Approaching Commercial Launch of e-Go Carbon Fiber Body Electric Automobile

2050 Motors, Inc. (OTCQB: ETFM) is a development stage public company formed to import, market and sell electric cars manufactured in China. Through a partnership with China-based Jiangsu Aoxin New Energy Automobile Co., Ltd, the company maintains United States distribution rights for a new electric automobile leveraging a revolutionary approach to the ever-evolving world of electric vehicles. Upon commercialization, the e-Go EV, which is currently in its final stage of development and ready for mass production, will be the only production line electric car constructed with a carbon fiber body and parts manufactured through a groundbreaking process that significantly reduces fabrication time and, as a result, cost.

In February, 2050 Motors gave investors an update on the status of the e-Go EV, announcing that the vehicle had commenced crash testing in China. In the tests, which were conducted in accordance with European, Japanese and Chinese test standards, the e-Go EV passed with impressive results, absorbing the full force of the collision and returning to its original shape. These results will serve as a solid foundation when, later this year, 2050 Motors proceeds with the U.S. Department of Transportation crash test program, which is required before the e-Go can be sold in the United States.

“This means that the carbon fiber body absorbed the full force of the collision and returned to its original shape,” Michael Hu, president and chief executive officer of 2050 Motors, stated in a news release regarding the crash test results. “I believe that no other automobile for the consumer market has ever displayed such a frontal crash resilience and shock absorbance of energy.”

While the company plans to initially sell and distribute e-Go vehicles manufactured in China, it has also announced a strategy to commence manufacturing in a new facility in Las Vegas, Nevada, in the future. In a January press release, 2050 Motors estimated that its long-term expansion plans could create more than 3,000 jobs over the next few years. If these plans come to fruition, the company could find itself in direct competition with leading electric vehicle manufacturer Tesla (NASDAQ: TSLA), whose high capacity ‘Gigafactory’ is currently under construction outside Sparks, Nevada, as well as automotive giant General Motors (NYSE: GM), which currently markets the all-electric Chevrolet Bolt.

“2050 Motors cannot allow Tesla to corner the commuter market in the same way they cornered the high-end market four years ago,” Hu continued. “It’s not 2050 Motors’ intention to competitively out sell the e-Go against the Model 3 from Tesla or the Chevy Bolt because of their already existing name recognition. However, it’s also true that 2050 Motors does not need to sell a significant number of vehicles for the company to become profitable.”

In preparation for the commercial launch of the e-Go EV, 2050 Motors began accepting deposits for the carbon fiber body electric automobile on March 17. The company is offering significant incentives to individuals who preorder the e-Go, including opportunities to win free automobiles or to trade in their e-Go vehicles for the highly-anticipated Ibis four door carbon fiber luxury sedan if and when it becomes available to the U.S. market.

For more information, visit www.2050motors.com

Moxian, Inc. (MOXC): Social Media Advertising Expected to Grow 30% This Year

Social media advertising is expected to grow 30 percent or more this year as measurability improves and the number of important platforms and types of units widen, challenging marketers when it comes to deciding where to allocate their advertising dollars. Facebook (NASDAQ: FB) still commands social media ad budgets for most marketers, but as Pinterest, Instagram and Snapchat prove their worth, they are grabbing a bigger share. The key for marketers is to look at social media holistically and determine which platforms and types of units best meet individual goals. Virtually untapped markets like China and India present an alluring growth opportunity for companies such as Moxian, Inc. (OTCQB: MOXC), which provides social marketing and promotion platforms designed to help merchants accelerate and advertise their business growth through social media.

China is projected to have upward of 525 million social media users by 2017, according to Statista.com, up from just 176 million in 2009. Facebook – which is banned in China – for comparison purposes, has 1.23 billion monthly active users and is worth more than $300 billion. China is home to the world’s largest population, with 1.4 billion citizens, followed by India, with 1.3 billion. As a result, the market for users and merchants looking to utilize an effective social media marketing campaign is effectively limitless.

For local organizations seeking exposure, paid social media advertising can actually be helpful. Facebook’s paid program, for example, allows users to run promoted posts with pay schedules based on ads per impression (how many users see the ad) or per click (how many users click on the ad), letting the user set the goal for the campaign. It also allows targeting by age, gender, location and interests.

Moxian offers targeted advertising campaigns that enhance interaction between users and merchants by using consumer behavior data compiled from the company’s database of user activities. The company has two core products: Moxian+ User App and Moxian+ Business App. The Moxian+ User App is designed for consumers to collect loyalty points from issuing merchants and to play games and win universal MO-Coins, which can be used globally with any merchant in the Moxian ecosystem. Moxian+ User App also provides consumers with a set of social networking features to set up personalized multimedia profiles; look for friends, interest groups, clans and topics; and share and chat with their social circles.

The Moxian+ Business App provides merchants the tools needed to covert customers into members and fans; issue loyalty points and redeem rewards; respond to customer inquiries through instant messaging; conduct targeted marketing campaign to members of the Moxian community in the form of ads and games; list products in a lightweight online shop; and process orders. The app also provides business reports and analytical insights for merchants.

For more information, visit the company’s website at www.Moxian.com

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Content Checked Holdings, Inc. (CNCK) CEO Kris Finstad Featured in ‘Built in Los Angeles’ Article

Built in Los Angeles recently posted the article ‘Scan For Your Dietary Restrictions With This Fast-Growing LA App’. The piece came to fruition following Content Checked Holdings, Inc.’s (OTCQB: CNCK) outreach to business and tech media with the company’s recent partnership and financial updates.

As a result, Kris Finstad, CEO of Content Checked, scored an interview with Built in LA to discuss the genesis of the company’s app and its continued growth in Los Angeles. The article captured the full story and focused on Finstad’s inspiration to develop this technology.

Built in LA is a growing online community that creates and curates exclusive content on local companies and startups, hosts monthly events and publishes data on the tech sector of Los Angeles – the perfect audience for ContentChecked. Built in LA enjoys a readership of nearly 50K unique visitors a month.

Sometimes, the inspiration for a great startup can come during a dark time. After suffering from two major strokes in 2010, Norway native Kris Finstad was forced to spend his days at home. The unfortunate situation did, however, allow him to spend more time with his nine-year-old daughter while she and her friends were home from school. One of the friends frequently visiting the family’s home had a long list of allergies that her parents had delivered to Finstad. As hard as he tried to avoid the extensive list of ingredients, he eventually made an error, and the girl was rushed to the emergency room.

Frustrated and confused, he searched for his mistake and was unable to find the ingredient that triggered the intense reaction. The doctors eventually revealed that is was an additive that was labeled something entirely different. Finstad contacted the girl’s father and proposed the idea of an app that would thoroughly scan food labels to prevent situations like this in the future.

The girl’s father, a CTO at a large Norwegian cellular phone provider, and her mother, one of Finstad’s neurologists, encouraged him to work on a schematic of what he envisioned as a form of therapy for his recovery. A short while later, Finstad returned with a detailed proposal of the app that would become ContentChecked.

“He came back and said, ‘I’ve quit my job now, how would you like to proceed?’” Finstad said. “It took me by surprise and I tried to reason with him but thought, what the hell, let’s do it.”

The two built the company over the next year and launched the Norwegian version of ContentChecked in 2012. The company now offers applications (ContentChecked, SugarChecked, MigraineChecked) that allow users to scan food items and check if a product fits into their dietary restrictions. ContentChecked shows users if products they are scanning contain any of their allergens, SugarChecked helps users stick to a sugar-free diet, and MigraineChecked warns users of potential triggers in food that may cause discomfort.

The following year, after the app had caught on in their home country, the duo decided to take on the U.S. market, relocating the company to Los Angeles. The company continued its growth and went public in April 2015, but their quick success did not come without a few speed bumps. Early on, the company only aggregated public ingredient data and quickly found that the error margin was around 85 percent. They decided to make their own database by contacting the FDA and food producers, creating one of the most extensive food databases in the world.

The company’s apps currently have 2.6 million combined users between the U.S. and Norway, 66 percent of which use the app at least five times a week. The second version of the app, which Finstad calls a ‘game changer’, will feature a shopping list and a recipe list filled with allergy/sugar/migraine friendly meals.

To view the entire article, visit http://dtn.fm/z6o9H

For more information, visit www.contentchecked.com

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Dominovas Energy Corporation (DNRG) Recognized in Seminal Department of Energy Report on the Advancement of Fuel Cell Technology

Early today, Dominovas Energy Corporation (OTCQB: DNRG), an energy solutions company dedicated to delivering clean, efficient and reliable electricity, announced its inclusion in a seminal report on the advancements and progress made in commercializing applications for fuel cell technology as a viable source for both baseload and back-up power generation. The report, titled State of the States: Fuel Cells in America 2015, was written by the Fuel Cell and Hydrogen Energy Association (FCHEA) with support from the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy’s Fuel Cell Technologies Office.

In the report, Dominovas is recognized for its progress toward supplying sustainable electricity generation capacity in areas throughout Africa. The FCHEA’s report acknowledges the company’s entry into “three multi-MW, multi-year, and potentially multi-million, even billion, dollar power provider agreements (PPA),” including agreements with the South Kivu Province, the Somico Mine and the City of David, all of which are located in the Democratic Republic of the Congo.

To view the full report, visit http://dtn.fm/1qDld

“With over 600 million sub-Saharan Africans without basic access to electricity, Africa represents the frontier market with the single greatest need for sustained and reliable clean power production,” Dr. Shamiul Islam, Dominovas Energy’s executive vice president of fuel cell operations, stated in today’s news release. “To date, no other fuel cell technology company has made comparable strides in securing contracts in Africa to deploy utility-scale units for clean fuel cell generated power production.”

Despite remaining relatively quiet on its efforts to continue to expand its presence in various frontier markets throughout Africa and Latin America, Dominovas considers its ability to engineer a reliable platform for delivering power to global communities most in need as its crowning achievement. Likewise, the company takes pride in its progress toward stimulating job creation domestically, as it plans to manufacture and support its proprietary RUBICON™ solid oxide fuel cell systems through the use of a robust supply chain located in the United States.

For more information, visit www.dominovasenergy.com

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Overstock.com, Inc. (OSTK): Agnostic t0.com Trading Platform is a Game Changer

The choice between agnostic and exclusive trading platforms has many similarities to the battle between Apple (NASDAQ: AAPL) and Microsoft (NASDAQ: MSFT) over the years. Apple’s Steve Jobs always touted his idea of a closed or exclusive system as being much better than Microsoft’s open or agnostic system. Each has its advantages, but as far as thinking about the customer and taking a utilitarian approach, the agnostic argument wins out every time. Overstock.com, Inc. (NASDAQ: OSTK) is following the agnostic approach with its new trading platform, t0.com, and believes it will revolutionize trading platforms moving forward.

Overstock.com announced at the 41st Annual International Futures Industry Conference its plan to complete the world’s first public offering using proprietary blockchain technology. The offering will allow Overstock.com shareholders to purchase Overstock.com blockchain or traditional preferred stock. The blockchain preferred stock will trade and settle exclusively through the t0.com platform and its alternative trading system.

“This is yet another historic event — the creation of a security that will trade and settle entirely on a distributed ledger,” said Patrick M. Byrne, CEO of t0.com, in a press release. “I’ve said from the beginning that blockchain technology is going to change the world of finance forever, and we’re leading that charge.”

t0.com is Overstock.com’s financial technology subsidiary and the leader in developing and deploying blockchain-based financial products to increase efficiency and transparency in capital markets.

Blockchain is a distributed database based on the bitcoin protocol that maintains a continuously growing list of data records hardened against tampering and revision, even by its operators. The initial and most widely known application of block chain technology is the public ledger of transactions for bitcoin.

Bitcoin is a digital asset and a payment system invented by Satoshi Nakamoto, who published the invention in 2008 and released it as open-source software in 2009. The system is peer-to-peer; users can transact directly, without an intermediary. Transactions are verified by network nodes and recorded in a publicly-distributed ledger called the blockchain. The ledger uses bitcoin as its unit of account. The system works without a central repository or single administrator, which has led the U.S. Treasury to categorize bitcoin as a decentralized virtual currency. Bitcoin is often called the first cryptocurrency, although prior systems existed. Bitcoin is more correctly described as the first decentralized digital currency. It is the largest of its kind in terms of total market value.

t0.com technologies are built upon decentralized, cryptographically protected ledgers, which anybody can access and inspect. This ensures fairness to the entire market, without regard for size or geographic location. t0.com’s radical transparency and true settlement combine to grant real, unambiguous ownership nearly instantly. If you buy it, you own it. It’s that simple.

For more information, please visit www.t0.com

Giggles N’ Hugs (GIGL) Delivering Childhood Dreams Wrapped in Peace of Mind and Good Nutrition

GIGL

Every child has dreams of a birthday party with themed settings that can only be crafted by his or her youthful imagination. Giggles N’ Hugs (OTCQB: GIGL) gets about as close as you can get to delivering on these dreams for youngsters who are part of mall-going families in the Los Angeles area. The Los Angeles-based company provides a practical mix of nutritional menu offerings set around themes such as superheroes for both boys and girls, mermaid, jungle, princess, pirate, cartoon pups, dinosaur, rock star and many more.

Giggles N’ Hugs was founded by Dorsa and Joey Parsi. The company’s start in 2008 followed the couple’s realization that there were no practical places to take their daughter where the establishment truly catered to the needs of young children. Like the true entrepreneurs that they are, they began to ask themselves questions around the subject and soon found the answers were not so apparent.

The Parsi’s soon realized that all of the “kid friendly” restaurants offered only adult-sized surroundings, from furniture to utensils, and worse yet – unhealthy menu selections. Mrs. Parsi was perpetually thinking of ways to make life more fun for her daughter while making it a little easier on herself, and so the questions continued. ‘Why wouldn’t this make sense for others?’

Giggles N’ Hugs is steadfast in its mission that the ‘going out to dinner experience’ no longer means compromising adult standards for those of children. All of the food at Giggles N’ Hugs is made with the freshest quality ingredients available. The company offers a variety of organic, healthy food which in turn provides parents the peace of mind that their children are eating food that is healthy for them. By weaving nutritional menu offerings in with customized party themes targeted to a child’s imagination, the company sees an avenue pointed toward long term growth, leading ultimately to shareholder value.

Giggles N Hugs, Inc. owns and operates youngster-friendly restaurants with play areas for children up to 10 years old in southern California. Company restaurants are located in the Westfield Mall in Century City, the Westfield Topanga shopping center in Woodland Hills, and the Glendale Galleria in Glendale, California. Founded in 2008, the company is based in Los Angeles, California.

Learn more by visiting www.gigglesnhugs.com

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Oakridge Global Energy Solutions, Inc. (OGES) – A Top-of-the-Line Battery Manufacturer

Oakridge Global Energy Solutions, Inc. (OTCQB: OGES) is on a mission to provide safer, zero-maintenance, long-life battery systems. To deliver its high-quality, “Made-in-the-USA” battery systems internationally, the company has made retaining its technological leadership a key priority.

With the recent appointment of IST Co. Ltd. — a leading transnational battery consulting company — Oakridge has made a major move to ensure it remains technologically state-of-the-art. The Tokyo-based IST team will join Oakridge’s advising team in Japan and support the company with two crucial initiatives:

  • IST will assist in providing Oakridge with continuing access to joint technology development opportunities for next-generation, rechargeable lithium batteries.
  • IST will also help with the commercialization of the Thin Film Solid State lithium battery technology which Oakridge has already successfully developed.

Through a previously established subsidiary in Hong Kong and working closely with IST, Oakridge means to establish a substantial presence in Japan by collaborating with the country’s foremost technical universities and research facilities, materials suppliers and advanced lithium ion manufacturing equipment suppliers. A good relationship with Japan is especially important in today’s increasingly turbulent geopolitical environment, and, in addition to being a technically-proficient nation, Japan is also a strong ally to the U.S. and Australia.

The Oakridge team prides itself on developing and delivering the latest technology and products. In early March, the company revealed that it would introduce its groundbreaking Liberty Series lithium-ion motorcycle batteries to commercial markets at the Daytona Beach Bikefest later in the month.

The Oakridge Liberty Series lithium-ion batteries are extremely powerful. They offer a highly reliable, long-lasting battery solution for all models of the iconic “Made in the USA” Harley Davidson, Indian and Victory motorcycles. These are large bikes with large engines that require a strong battery to start. Utilizing Oakridge’s specialized battery management system and proprietary electro-chemistry, the Liberty Series batteries effectively start these large bikes. These batteries can also go without charging for up to 12 months. Plus, they can remove up to 17 pounds from the weight of the largest bikes, as they are considerably lighter due to the inherent lightness of lithium, the lightest metal in existence.

Oakridge’s goal is to continue to provide cutting-edge technology, the highest quality and reliability and affordable pricing to its customers. With its Liberty Series lithium-ion batteries, it does exactly that.

For more information, visit www.oakridgeglobalenergy.com

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Laguna Blends, Inc. (LAGBF) Leveraging Network of Independent Affiliates to Tap into $3.4 Trillion Global Wellness Industry

Laguna Blends, Inc. (OTC: LAGBF) is a network marketing company focused on the generation of sales through independent affiliates. Leveraging innovative tools and technologies, the company’s affiliates are able to build international businesses from their own homes while effectively capitalizing on the performance of some of the world’s most rapidly expanding, in-demand markets. Affiliates also have the ability to recruit new affiliates, expanding Laguna’s reach into the $3.4 trillion global wellness industry.

Laguna’s leading product category focuses on the unique nutritional health benefits offered by hemp-based beverages. Caffe, the company’s first product, is an instant, “just add water” hot coffee beverage that’s infused with both whey and hemp protein, giving it a powerful protein punch. Through the commercialization of Caffe, Laguna is tapping into the expansive global market for coffee.

According to reports from the Coffee Association of Canada (CAC), coffee is consumed by a larger proportion of adults than any other beverage, excluding water. Approximately two-thirds of adult Canadians drink coffee on a daily basis, according to the CAC, with coffee drinkers consuming, on average, 3.2 cups per day. When combined with the strong performance of the global hemp industry, which was valued at nearly $500 million in 2012 by the Hemp Industries Associates, the market potential for Caffe moving forward is tremendous.

In early March, Laguna launched sales of its protein coffee beverage through 135 independent affiliates throughout the United States and Canada. In less than a week, the company’s affiliate base grew to include 278 independent members, marking a growth rate of 105 percent. Stuart Gray, Laguna’s president and CEO, explained the company’s strong start in a recent news release.

“Laguna has launched its business with a high level of interest from independent affiliates residing in the USA and Canada. The demand for high quality, functional beverage products throughout the United States and Canada, coupled with a viable business opportunity, has attributed to the spike in affiliate interest,” he stated. “In addition, the positive feedback on Laguna’s first product to market, Caffe, has been fantastic.”

In addition to Caffe, Laguna has been granted approval from Health Canada for the commercialization of Pro369, a single serving, “on-the-go” hemp protein that’s available in four flavors, including chocolate banana, mixed berry, vanilla caramel and tropical powder. Pro369 is water soluble, meaning that it can be mixed directly into water or milk, and it can also be blended into shakes and smoothies for an added boost of omega 3-6-9 and ginseng.

On March 3, Laguna set the stage for additional expansion of its product line when it signed a letter of intent with Robert Lamberton Consulting regarding the development of a “Limitless functional beverage brain health and memory coffee” product. Under the terms of the LOI, all hard costs associated with the development of the product will be billed to Robert Lamberton Consulting. The two parties intend to enter into a formal research and development agreement outlining the details of the relationship before April 15, 2016.

For more information, visit www.lagunablends.com

International Stem Cell Corp.’s (ISCO) Virgin Birth Technology holds the Promise of Stemming Progress of Parkinson’s Disease

We are apt to scoff at stories of virgin birth, and the term itself is something of an oxymoron, since the virgin usually has had some ‘knowledge’ of a male progenitor. Many of the classical Greco-Roman heroes, like Hercules, who were the product of a virgin birth, were fathered by gods, as was the Christ, according to Christian dogma. But virgin birth or, at least, reproduction that takes place in the absence of fertilization, called parthenogenesis, occurs in nature all the time, both in plants (e.g. roses and orange trees) and animals (some kinds of ants, bees and wasps). Now, researchers have discovered ways of engendering parthenogenesis in mammals.

Early work on stem cells involved human embryos and, consequently, gave rise to ethical debate and controversy that threatened further research efforts. But in a ground-breaking paper titled ‘Nonhuman Primate Parthenogenetic Stem Cells’ (http://dtn.fm/3aP4i), published in 2003, Kent Vrana et al, wrote about their stem cell work using monkeys and reported that ‘stem cells were created via parthenogenetic activation of eggs’. This use of non-human cells provided a route out of the moral dilemma. Then, building on the insights of Vrana and his colleagues, a team at the privately-held Stemron Corporation of Rockville, Maryland, led by David Wininger reported in ‘Human Embryonic Stem Cell Lines Derived from Discarded Embryos’ (http://dtn.fm/o8ZcS) that it had ‘grown parthenogenetic human embryos to the blastocyst stage at which stem cells can be obtained’ and that ‘cells taken from one of the embryos survived for a few days’.

An April 2003 story in New Scientist titled ‘Virgin birth method promises ethical stem cells’ (http://dtn.fm/e2eWb), commenting on the Wininger breakthroughs, discusses how this is possible. Unfertilized eggs have two complete sets of chromosomes and during fertilization one set is discarded. ‘But an electric or chemical shock can make the egg develop as if fertilized and retain the extra set’. In parthenogenesis, an unfertilized egg keeps two sets of chromosomes and begins developing as if it had been fertilized and thus ‘produces embryos that could never become human beings’. The destruction of ‘these embryos to obtain stem cells would avoid the ethical concerns that have led to restrictions or bans on embryonic stem cell research in many countries.’

One area involving stem cells that shows remarkable promise is in the treatment of Parkinson’s disease. According to the Harvard Stem Cell Institute HSCI), Parkinson’s is ‘associated with the death of cells in a part of the brain… which produces the neurotransmitter dopamine’. Researchers at the HSCI have ‘orchestrated the transformation by biologically reprogramming the mature skin cells into induced pluripotent stem cells, and then encouraging the stem cells to become dopaminergic neurons. Neurons were also made from skin cells collected from individuals with genetic mutations associated with high risk for Parkinson’s disease’.

International Stem Cell Corporation’s (OTCQB: ISCO) UniStemCell for Parkinson’s has completed the Food & Drug Administration’s (FDA) Investigational New Drug (IND) phase, and the company announced recently that it had received authorization to initiate a phase I/IIa clinical trial of human parthenogenetic stem cells-derived neural stem cells (ISC-hpNSC) for the treatment of Parkinson’s Disease.

The phase I/IIa clinical study, which will be performed at the Royal Melbourne Hospital in Melbourne, Australia, is a dose escalation safety and preliminary efficacy study of ISC-hpNSC intracranially transplanted into patients with moderate to severe Parkinson’s disease. The open-label, single center, uncontrolled clinical trial will evaluate three different dose regimens of 30,000,000 to 70,000,000 neural cells. A total of 12 participants with moderate to severe Parkinson’s disease will be treated. Following transplantation, the patients will be monitored for 12 months at specified intervals to evaluate the safety and biologic activity of ISC-hpNSC. PET scans will be performed at baseline, as part of the screening assessment, and at 6 and 12 months after surgical intervention. Clinical responses compared to baseline after the administration of ISC-hpNSC will be evaluated using various neurological assessments.

In announcing the study, Russell Kern, PhD, ISCO’s executive vice president and chief scientific officer commented, “We are the first company in the world to conduct clinical trials of human pluripotent stem cells based product for the treatment of Parkinson’s disease. We believe the outcome of the study will produce findings in-line with our preclinical studies, where we demonstrated not only safety of our proprietary neural stem cells, but also their functional efficacy. The cells were able to successfully integrate into the brain and provide a significant increase of dopamine levels in the nigrostriatal system”

This is welcome news. As the Harvard Stem Cell Institute reminds us: ‘Approximately one to two percent of the population over the age of sixty receives a diagnosis of Parkinson’s disease, although scientists believe that may be a very conservative estimate (and) at least one million Americans are currently known to be living with the condition.’

For more information, visit www.internationalstemcell.com

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Immune Therapeutics, Inc. (IMUN) Armed with Expertise in the Immune System to Fight Infectious Diseases

Immune Therapeutics, Inc. (OTCQB: IMUN) centers its works on applying its patented immunotherapy to fight chronic diseases, such as cancer, which affect people of all ages and races all over the world. Leveraging the body’s natural immune system, the company’s product line and immunotherapy technologies are engineered to enhance treatment for those suffering with HIV/AIDS, chronic inflammatory diseases, and a variety of autoimmune diseases.

One of IMUN’s promising treatments is Low Dose Naltrexone (LDN), or Lodonal, as it is known on a global scale. Lodonal has its origins in the FDA-approved 50mg Naltrexone. Initially known to treat opiate dependencies, the Immune Therapeutics patented treatment, which covers a wide range of indications, is currently used as an immune modulator. Lodonal /LDN works by boosting levels of endorphins (peptides produced in the brain and adrenal glands). These natural peptides are very effective modulators of the immune system. When patients take Lodonal, it attaches to opioid receptors in the brain and immune cells and temporarily blocks endorphins signaling the body in order to increase endorphin production. The increased endorphin production facilitates the activity of stem cells, macrophages, natural killer cells, T and B cells and other immune cells. Lodonal is also effective in preventing immune system over activity, the core of autoimmune disorders, and reduces the release of inflammatory and neurotoxic chemicals in the brain.

New York physician Dr. Bernard Bihari, who has studied immune responses primarily in HIV/AIDs patients, has produced a three-point mechanistic approach to the use of LDN showing the following three distinct increases within the immune system. The first increase is within met-enkephalin (an endorphin produced in large amounts in the adrenal medulla) and endorphin in the blood stream. The second increase occurs within the number and density of opiate receptors on the tumor cell membranes, thereby making them more responsive to the growth-inhibiting effects of the already present levels of endorphins, which in turn induces apoptosis in the cancer cells. Third, increases are stimulated within absolute numbers of circulating cytotoxic T cells (CD8+/TH1) and natural killer cells (“NK cells”), as well as NK cell activity.

IMUN focuses on the development and commercialization of therapeutic treatments for cancer, HIV/AIDS, autoimmune diseases, and immune disorders in the United States. Currently, the company is developing IRT-101, an active immunotherapy systemic administration of methionine-enkephalin that works by stimulating a patient’s immune system against infectious diseases, autoimmune diseases, immune disorders, and tumor cells. The company is headquartered in Orlando, Florida.

Learn more by visiting www.immunetherapeutics.com

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ShelfieTech Ltd. (CSE: SHLF) (OTCQB: SHLFF) Hits Key Corporate Milestones with Funding Growth, Product Progress

December 22, 2025

This article has been disseminated on behalf of ShelfieTech Ltd. (CSE: SHLF) (OTCQB: SHLFF) and may include paid advertising. Retail technology innovators that can turn research progress into market-ready solutions often attract strong attention, especially when they achieve tangible milestones that move them closer to wide adoption. In a recent corporate update, ShelfieTech (CSE: SHLF) […]

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