• Developing series of blockchain technology initiatives to augment existing proprietary big data analytics
• 100 billion daily data computations with 2 million user sessions per month
• Licensing agreements with leading financial news agencies, web portals, stock exchanges
• AI market estimated at $16 billion by 2022 at a CAGR of 62.9% from 2016 to 2022

AnalytixInsight (TSX.V: ALY) (OTCQB: ATIXF) is an artificial intelligence (AI) company that transforms data into knowledge. The company has developed a proprietary, machine-learning technology that algorithmically analyzes big data and distills it into actionable insights. AnalytixInsight has strategic initiatives in fintech, blockchain and workflow analytics, and its technology is scalable and extendable to virtually any data-driven industry such as sports, communications, healthcare, insurance or government.

The company’s flagship product – CapitalCube.com – is a financial portal providing comprehensive company analysis including on-demand fundamental research, portfolio evaluation and screening tools on over 50,000 global equities and North American ETFs. CapitalCube’s online portal is designed to empower investment ideas by providing in-depth analysis, peer-to-peer performance evaluations, accounting and earnings reports, dividend strength and AI-supported information about likely corporate actions such as dividend changes, share buybacks and acquisitions. AnalytixInsight provides a robust technology that is frequently rebalanced to maintain a desired risk profile, matching risk to ideal ETF exposure, with regular compliance reporting.

CapitalCube’s freemium pricing model allows free access to basic financial information, with additional in-depth analysis and predictive analytics provided at a rate of $25 per month, and customized peer analysis for $300 per month. CapitalCube publishes 3,000 articles daily and has multi-language capabilities. Thomson Reuters and Africa Investor have recently been added to the growing network of content partnerships that already includes Euronext NV, Yahoo Finance and The Wall Street Journal.

Euclides Technologies is a subsidiary company focused on Field Service Management software solutions, led by a team with decades of experience in developing and implementing workforce management solutions for large global corporations. With worldwide customers representing over 100,000 field service personnel across multiple industries, Euclides Technologies has a deep understanding of the increasing amount of data generated within the industry, as well as the analytics solution offerings to transform that data into knowledge.

MarketWall is a Fintech subsidiary that develops integrated software solutions as part of an ecosystem of smart devices that includes PCs, tablets, smart phones, wearable mobile devices and Smart TV. AnalytixInsight Inc. has joint ownership in MarketWall together with Intesa Sanpaolo, Italy’s largest retail bank which has over 4,000 branches and a market capitalization of $40 billion Euros. MarketWall is expected to deploy its real-time stock trading and mobile banking app to Intesa Sanpaolo’s 12.6 million customers in six European countries during 2018. The mobile stock trading application will directly interface with Intesa Sanpaolo’s established MarketHub trading platform. As a Samsung Global Partner, the MarketWall app is preloaded in mobile devices in certain areas in Europe.

AnalytixInsight is currently evaluating and pursuing Blockchain initiatives which are contiguous with its artificial intelligence platform, to use a distributed ledger technology to reduce transaction costs and settlement times for its users, partners, and subsidiaries. The Company believes these initiatives will enhance current revenues being received from existing multi-year agreements with its partners.

For more information, visit the company’s website at www.AnalytixInsight.com

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• State-licensed online unsecured consumer loan company
• Attractive alternative to expensive payday lenders
• Cumulative loan volume increased to more than $16 million end of 2017
• Since January 2015, cumulative loan volume has increased by 192%

IEG Holdings Corp. (OTCQB: IEGH) is a publicly traded, global leader in consumer finance providing small-sized online personal loans in the United States via a state-licensed operating subsidiary, Investment Evolution Corporation, under the consumer brand “Mr. Amazing Loans.” Based in Las Vegas, the company originates consumer loans in 20 states: Alabama, Arizona, California, Florida, Georgia, Illinois, Kentucky, Louisiana, Maryland, Missouri, Nevada, New Jersey, New Mexico, Ohio, Oregon, Pennsylvania, Texas, Utah, Virginia and Wisconsin via its online platform and distribution network. IEGH is a licensed direct lender with state licenses and/or certificates of authority to lend in each state and offers all loans within the prevailing statutory rates.

Mr. Amazing Loans is a leading FinTech company specializing in dedicated loan amounts of $5,000 to $10,000 offered directly to consumers through an easy-to-use website known for its professional interaction with applicants. All loans are originated, processed and serviced out of the company’s Las Vegas corporate offices, eliminating the need for physical locations in each state where IEGH is licensed to conduct business. The company’s loans are unsecured consumer loans that mature in five years at interest rates significantly less than those of payday lenders. Consumers are able to receive same-day processing and are assured of no hidden or additional fees, no prepayment penalty, with repayment and interest rates fixed at 29.9% or less Annual Percentage Rate (APR) for the life of the loan.

The Center for Responsible Lending states the typical payday loan has rates ranging from 391% to 521% APR on loans that typically range from $100 to $1,000. Conversely, Mr. Amazing Loans’s terms are designed with low fixed repayments to fit into consumer budgets with the added goal of helping clients reach a stronger financial position. Loan funds are deposited directly into an approved consumer’s checking account and may be approved the same day after necessary application documentation is received.

IEG Holdings has also incorporated Investment Evolution Crypto, LLC., a 100 percent owned subsidiary, and tasked the new company with exploring business opportunities in the cryptocurrency/blockchain industry. Specifically, the subsidiary company will explore the legalities and economic risks of entering into a joint venture with IEGH’s other 100 percent owned subsidiary company, Investment Evolution Corporation dba Mr. Amazing Loans. Among the questions to be answered during this development planning stage are whether Mr. Amazing Loans should accept repayment of customer loans in the form of leading crypto/blockchain currencies such as Bitcoin, provide the equivalent of USD $5,000 and $10,000 loans to consumers in cryptocurrencies, and potentially create and issue an Investment Evolution cryptocurrency.

Paul Mathieson, IEG Holdings’ chairman and Chief Executive Officer, has over 19 years of finance industry experience in lending, funds management, stock market research and investment banking. He has been a member of the board of directors at IEGH since 2012 and of its subsidiary since 2009. Mathieson founded IEG Holdings Limited in Sydney, Australia, launching the Amazing Loans business in that country in 2005 and then in the United States via IEGC in 2010. He was awarded Ernst & Young’s 2007 Australian Young Entrepreneur of the Year (Eastern Region). Mathieson is joined by Carla Cholewinski, who serves as chief operating officer with over 37 years of experience in the finance industry including banking, credit union management, regulatory oversight, debt securitization and underwriting.

For more information, visit the company’s website at www.InvestmentEvolution.com

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• SinglePoint capitalizing on exceptional growth in legal cannabis and cryptocurrency markets via its subsidiary, SingleSeed
• Bitcoin price has increased from $1,000 to over $15,000 in the last year
• Legal cannabis market forecast to reach more than $63 billion by 2024

A diversified holding company with operations in multiple industries and verticals, SinglePoint, Inc. (OTC: SING) is focused on providing full-service mobile technology solutions by capitalizing on two high-performing market sectors, legal cannabis and cryptocurrencies. Over the past year, the price of bitcoin has exploded, from just over $1,000 in January 2017 to over $15,000 on January 9, 2018. The legal cannabis market has also seen significant growth with increasing legalization in North America and Europe, and it’s projected to reach over $63 billion in global sales by 2024, up from just over $14 billion in 2016 (http://dtn.fm/klE6A).

SinglePoint will proceed with a full launch of its subsidiary, SingleSeed, during the first quarter of 2018 to provide a platform for retailers and consumers in the legal cannabis industry to process cryptocurrency payments. Based on blockchain technology, the SingleSeed platform is a proprietary payment processing app that enables payment by bitcoin instead of conventional currency. Blockchain technology facilitates a more efficient, faster and more secure payment process, as well as providing an alternative to many operators in the cannabis sector that don’t have access to traditional banking processes.

Apart from facilitating cryptocurrency payments, the SingleSeed app enables merchants to upload photos and descriptions of their products, and track and update inventories. The app is user-friendly, providing an easy, efficient account registration process to facilitate immediate point-of-sale transactions. The platform also enables dispensaries to use it for text message marketing in order to develop customer relationships and build trust.

While SingleSeed was designed to provide a payment solution to the cannabis industry, it is not industry-specific, and SinglePoint will be able to customize the platform for any industry application in the future. SinglePoint’s proprietary payments solution is currently based on bitcoin, but the company intends to accommodate ethereum in the near future. Currently priced at over $1,200, ethereum could triple in value by the end of the year, according to co-founder Steven Narayoff (http://dtn.fm/Nsw70). SinglePoint’s ultimate goal is to accommodate payments by both cryptocurrencies within its integrated mobile solutions for use by enterprises of all kinds.

With a market cap of over $100 million, SinglePoint is focused on acquisitions of small to medium-sized companies that have developed innovative technologies to expand its portfolio, with a view of providing investors with investment opportunities across a wide range of assets. On December 5, 2017, the company announced a joint venture with Smart Cannabis Corporation (OTC: SCNA) to license and market Smart Cannabis’ SMART APP. Based on IoT technology, SMART APP enables cannabis growers to measure all aspects of cultivation, from soil nutrient levels to watering cycles and carbon dioxide content in the air. As part of the joint venture agreement, SMART APP will integrate SinglePoint’s bitcoin payment solution to enable growers to process safer and more secure transactions. SinglePoint also entered joint venture agreements with Global Payout (OTC: GOHE) and AppSwarm (OTC: SWRM) last year to strengthen its cryptocurrency payment services and to provide value-added solutions, including licensed in-home delivery services.

For more information, visit the company’s website at www.SinglePoint.com

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• Standard Lithium recently completed option agreement on 33,000-acre lease in longtime commodities-producing region
• Company expects existing historical data to streamline quick turnaround in resource estimates
• Lithium exploration gaining popularity as tech industry companies seek to shore up supply lines
• Recent drilling order announcement clearly puts Administration on side of energy industry

Standard Lithium Ltd. (TSX.V: SLL) (FRA: S5L) (OTCQX: STLHF) is exploring the possibility that oil resource-rich Southern Arkansas could become a large source of lithium amid demands for the modern tech commodity.

Since 1920, the Smackover region’s oil fields near the state’s boundary with Louisiana have been a major employer, even though the boom years ended about a decade after the first large discovery. The oilfield brine byproduct was long considered a nuisance, but, in time, it came to be celebrated for chemicals with fire-retardant properties. Following a second round of mineral exploration, Arkansas has become the world’s largest producer of bromine.

A modern need to augment the scarce mineral resources that make up the high-tech, high-efficiency lithium-ion batteries in so many mobile phones and other Internet-connected consumer electronics, as well as electric vehicles, is fueling what could become a game-changing third round of mineral excitement in the region. Automakers and other companies competing in a global marketplace are jostling with each other to secure a steady supply chain well before an actual need for more lithium-ion battery components exists.

Lithium-ion batteries are also significant players in mass storage systems for electrical power grid operators. As the systems look for longer capacity in their storage technology, lithium is expected to remain a key player (http://dtn.fm/uHC8w), particularly as the cost of the batteries continues to fall. However, electric vehicles and governmental demands for ‘clean energy’ are expected to dominate the market for the batteries in the coming decade or more.

Standard Lithium, which considers part of its mission to minimize resource and political risks in its exploration efforts, considers the 33,000 acres of Smackover Formation brine leases it signed an option agreement for this month to be fertile ground, given the area’s long history of brine production; significant existing infrastructure; access to roads, power and water; and the trained workforce in the region, as well as its existing brine extraction, processing and re-injection permitting regime.

“Due to the wealth of already-available data from our new project area, we can start the process of compiling a maiden resource estimate for this large lease package extremely quickly, with a minimum of additional intrusive investigation,” President and COO Andy Robinson stated in a news release about the agreement issued on January 8 (http://dtn.fm/Pgrm1).

The existing infrastructure and data would allow Standard Lithium its best chance of quickly adding resources to its assets.

The company states that Arkansas produces the equivalent of 42.6 million cubic meters, or 9.38 billion gallons, of brine per year, based on the Arkansas Oil and Gas Commission’s reported average brine production from between 2010 and 2016. Almost all of those billions of gallons of brine came from the Smackover Formation.

The Smackover Formation itself extends through Texas, Arkansas and Louisiana, and it has produced billions of barrels of brines during the last eight decades from an “extensive and extremely well characterized” aquifer, according to the company’s analysis.

Standard Lithium also has a significant lithium exploration project under way in Southern California’s Mojave Desert. Having a large domestic source for lithium-ion batteries would help satisfy concerns about a secure supply chain in United States markets that currently see half of their lithium supply come from imports. According to the U.S. Geological Survey, the United States reported only 38,000 tons of defined lithium reserves.

“The U.S. has a lot more untapped lithium resources than economically mined reserves at this point,” USGS mineral commodity specialist Brian Jaskula said in a February report (http://dtn.fm/hAv4t). In addition, the recent government order opening offshore waters to drilling (http://dtn.fm/Wd23D) is a clear indication of Administration support for the overall tapping of oil resources.

For more information, visit the company’s website at http://nnw.fm/standardlithium

• GRCK front-and-center in booming CBD market, which is expected to reach $2.1 billion in annual sales by 2020
• The company provides current and comprehensive information via its CBD Marketplace and CBD TV channel.
• Learning center articles explore various topics, including the benefits of CBD oil for various conditions

Grey Cloak Tech, Inc. (OTCQB: GRCK) is front-and-center in the rapidly-growing medical cannabis market and poised with one-stop information solutions and new age products and services as awareness increases regarding the potential health benefits of cannabinoids.

The timing is right to position GRCK and its wholly-owned subsidiary, Eqova Life Sciences, in a market with CBD products that are projected to grow at an astronomical rate of 700 percent and reach annual sales of $2.1 billion by 2020 (http://dtn.fm/o0BlF). The company is leading strides in this sector by providing comprehensive and current information with the recent launch of a new and cutting-edge internet CBD Marketplace and CBD TV channel.

The online marketplace (www.CBD.co) offers a new-era gateway into all things CBD and hemp oil, including a learning center, e-commerce, and bot/messaging help functionality. The learning center offers information and research articles that explore various topics, such as the differences between CBD and THC and dosage guides. Educational articles offer tantalizing details on the potential benefits of CBD oil for various conditions ranging from pain, migraines, arthritis and anxiety to epilepsy. They also explore safety of its use for children and pets.

Through the marketplace, customers have access to purchase the company’s wide variety of CBD products, including oils, skincare soaps, balms and solutions, vapes and pet products. Transactions are secure, and the marketplace offers engaging and well-organized content, user-friendly navigation and added customer-centric enhanced capabilities with instant bot/messaging help.

In addition, GRCK just launched the company’s brand new YouTube channel, CBD TV (www.CBD.co/tv), as another valuable source for current information. The channel will feature a wide array of content, including educational videos and in-house staff product reviews, as well as interviews with industry leaders and top executives in the CBD and hemp markets. Speaking to the strategy leading to the creation of the new channel, Grey Cloak’s Director of Content and Research, Nicole Gleichmann, stated in a news release, “Frankly, there is no ‘go-to’ source of reliable information on CBD or hemp on the web. Thus, it’s a great honor to bring the CBD Learning Center and CBD TV to the public.”

Gleichmann further indicated that the timing could not be better for the launch. With the sector’s rapid growth and the use of new products and therapies implementing CBD and hemp, now is indeed a good time to poise the company in a market vying to meet increasing demand.

For more information, visit the company’s website at www.GreyCloakTech.com

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• Lexaria’s CEO posts end of 2017 summary
• Multiple transformative developments – IP strengthened, broad patents awarded, finances secured
• Foundation for the future established – multiple opportunities on horizon

If the past is any prologue, Lexaria Bioscience Corp. (CSE: LXX) (OTCQB: LXRP) should have a break out year in 2018. Lexaria’s CEO, Chris Bunka, recently posted ‘LXRP CEO’s End of 2017 Summary’. It was a transformative year with multiple accomplishments that should establish a strong foundation for the future.

Lexaria Bioscience has developed, patented and commercialized a cost-effective lipophilic delivery technology, DehydraTECH™, to enhance the performance of beneficial compounds in ingestible products. Already scientifically proven to enhance absorption of orally ingested cannabinoids, Lexaria’s novel drug delivery platform is believed to be applicable across a wide range of different vitamins, drug types and cannabinoids, dramatically impacting bio-absorption and bioavailability, as well as taste, smell and speed of action.

Lexaria’s DehydraTECH™ technology is a potential game changer for the delivery methodologies of many commonly used active pharmaceutical substances. The technology provides an additional layer of effectiveness designed to harmonize with the intellectual properties of manufacturers, and it can be used with both patented and generic pharmaceutical substances. This breakthrough plays into Lexaria’s long term strategy to partner with leading pharmaceutical, biopharma, nutraceutical, vitamin and food companies to make payload delivery more predictable, safer and more effective.

The first item addressed in the CEO summary was company finances. With a commitment to enhancing shareholder value, Lexaria cleaned up its balance sheet, raised well over $4 million and paid off all its debt. With cash in the bank, the company announced a $1 million budget for R&D using its patented DehydraTECH™ absorption and palatability-enhancing technology to create even more long term value. The company continued multiple absorption tests and formulation experiments, and it continues to pursue a number of intellectual property (IP) enhancement procedures to expand its IP portfolio.

The most significant and transformational developments of 2017 centered on the incredible value created with Lexaria’s intellectual properties. Late in 2016, Lexaria received its first U.S. patent award. Then, in the first half of 2017, the company received its first patent award in Australia. Lexaria announced in November that it had received a broad ranging U.S. patent award for its DehydraTECH™ as a delivery platform for a wide variety of active pharmaceutical ingredients. The U.S. patent includes all cannabinoids including THC, fat soluble vitamins, non-steroidal anti-inflammatory drugs (“NSAIDs”) and nicotine. Lexaria is continuing to advance all of its 33 other patent applications pending around the world. The impact of these patents not only creates value and validates Lexaria’s technology; it also opens untold avenues of business opportunity, some of which may be realized over the course of the coming year.

Lexaria has also taken large positions in subsidiary companies that could benefit from the global liberalization of cannabis. Lexaria owns 50 percent of Ambarii Trade Corp., which may offer international opportunities for a class of mouth-melt consumer products delivered with Lexaria’s technology. Lexaria consolidated ownership of PoViva Tea LLC and now own 100 percent. The company also successfully introduced TurboCBD™, a 100 percent-owned brand of hemp oil empowered with DehydraTECH™.

The company’s stock has performed well over the last year and, given all the progress, may outperform in 2018. Lexaria up-listed to the larger, more recognized OTCQX market, and the company filed an S4 prospectus to re-domicile the company from the U.S. to Canada in an effort to exploit opportunities in the Canadian cannabinoid products sector.

As the abundance of good news from last year begins to sink in, it certainly appears that Lexaria is making all the right moves to make 2018 even better.

For more information, visit the company’s website at www.LexariaBioscience.com

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• Offer to expire on February 22, 2018, and represents 4.99 percent of outstanding common shares as of October 31, 2017
• Transaction calls for exchange of 13 shares of IEG Holdings common stock for each share of LendingClub, up to an aggregate of 20.7 million shares
• IEGH sees tender offer as a solid short-term investment for its own shareholders

IEG Holdings Corporation (OTCQB: IEGH) recently announced (http://dtn.fm/zMd0F) that it has begun a tender offer for 4.99 percent of the common shares of LendingClub Corporation (NYSE: LC). The offer, set to expire on February 22, 2018, is for up to an aggregate of 20,701,999 common shares. The transaction calls for the exchange of 13 shares of IEG Holdings common stock for each share of LendingClub.

IEGH believes that the offer is a solid short-term investment for its shareholders. In connection with the offer, IEG Holdings prepared a Letter of Transmittal and submitted a form S-4 with the SEC.

Las Vegas-based IEG Holdings provides $5,000 and $10,000 unsecured consumer loans under the brand name ‘Mr. Amazing Loans’ through its website, www.MrAmazingLoans.com. It is licensed and/or holds certificates of authority to originate direct consumer loans in 20 states. The company provides loans through its online application portal to residents of those states, with all loans originated, processed and serviced out of its centralized Las Vegas head office.

ACF Equity Research, on January 4, 2018, estimated that IEG Holdings revenues in 2018 will reach $2,911,000, compared to $2,135,046 actual in 2016 (http://dtn.fm/KgxK9). The research report noted that ACF also estimates a high 80 percent repeat loan business for the company.

LendingClub (http://dtn.fm/03DsX) offers loans of up to $40,000 for consumers, as well as small business loans of up to $300,000. It is an online marketplace connecting borrowers and investors. It began operations in 2007.

For more information, visit the company’s website at www.InvestmentEvolution.com

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• Blockchain technology has the potential to transform supply chain management
• Complex commodity exchanges are traditionally fraught with disputes, driving up costs
• Exclusive blockchain platform for oil and gas industry under development
• Adoption of technology seen as necessary by majority of oil and gas executives

Petroteq Energy Inc. (TSX.V: PQE) (OTCQX: PQEFF) is a Canadian-registered, publicly traded company engaged in the development and implementation of proprietary technologies for the environmentally safe extraction of heavy oils from oil sands, oil shale deposits and shallow oil deposits. The company’s proprietary process produces zero greenhouse gas, zero waste and requires no high temperatures. As a forward-thinking pioneer in the energy industry, Petroteq is also participating in a blockchain initiative aimed at solving the global transaction needs of the oil and gas industry.

The company’s entry into the blockchain arena, appropriately named PetroBLOQ, is a collaborative effort with First Bitcoin Capital Corp. (OTC: BITCF) that aims to transform the ongoing problems of disputed oil and gas transactions. PetroBLOQ recently joined the 200-member Enterprise Ethereum Alliance (“EEA”), known as the world’s largest open-source blockchain initiative representing a diverse community of global industry experts (http://dtn.fm/1DLtA). PetroBLOQ is the company’s blockchain technology, the first blockchain-based platform developed exclusively for the supply chain needs of the oil and gas sector.

In a 2016 report issued by Deloitte Consulting and summarized in Rigzone (http://dtn.fm/EKW6u), an online oil and gas industry resource, 55 percent of oil and gas executives surveyed agreed that blockchain technology will be a requirement if companies are to retain a competitive advantage in the future. Another 45 percent acknowledged the disruptive potential that blockchain offers with its ability to encrypt connections and eliminate the role of third parties in transactions. One value of blockchain lies in its ability to fundamentally change the way certain processes are performed, bringing instant transactional verification for product trades.

Blockchains are, by design, built to increase transparency, share efficiencies, securely store and manage data, improve the speed of transactions and, potentially, reduce operating costs. The technology’s ability to create smart contracts offers a distinct advantage to the oil and gas industry, which, historically, has been a hotbed of logistical challenges, as discussed in an article published by the Wall Street Journal (http://dtn.fm/L0LvP). Indeed, experimenting with blockchain to make oil and gas trading more efficient is the subject of discussion around many boardrooms. David Eyton, head of technology for BP, said BP is exploring the implications of using blockchain in the energy sector, noting “there are uses for blockchain that could give us a competitive advantage.”

Petroteq Energy CEO Alex Blyumkin said the blockchain venture makes sense as the oil and gas industry seeks to modernize its resources. With its patented technologies to economically extract heavy oils through an environmentally-friendly, closed loop system, Petroteq is already dramatically lowering the cost per barrel and leaving behind only clean, dry sand. The addition of PetroBLOQ’s blockchain technology will add to the company’s stable of valuable products that underscore its belief in clean, sustainable energy and social responsibility.

For more information, visit the company’s website at www.Petroteq.energy

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• New cannabidiol marketplace offers top-quality products and educational information
• Products offered through the site are carefully vetted for quality and safety
• CBD market estimated to reach $2.1 billion by 2021

Grey Cloak Tech Inc. (OTCQB: GRCK), a growing hemp oil products distributor (through its recently acquired wholly owned subsidiary Eqova Life Sciences), has officially launched CBD.co, a premier online cannabidiol (CBD) marketplace. Grey Cloak Tech and Eqova are working to bring trust and transparency to the burgeoning CBD industry, giving consumers access to the best and latest research, innovations and products.

CBD.co has partnered with leading brands to offer the highest-quality products, and the site also provides customers with clear information and outstanding customer service. Each company offering products through CBD.co has been carefully vetted to ensure that its merchandise has clear and accurate labels, its products adhere to the highest quality and safety standards and its suppliers’ claims have been substantiated.

Cannabidiol and full-spectrum hemp oil have been shown to have positive effects on the mind and body, which makes it extremely unfortunate that so much misinformation exists and so many unscrupulous providers have muddied the marketplace. CBD.co aims to provide a safe and reliable marketplace where CBD and hemp oil users can obtain quality products and reliable information.

Through the website, the best prices and full customer satisfaction are guaranteed. If a patron finds the same product offered elsewhere at a lower cost, CBD.co will immediately refund the difference, plus an additional 10 percent. The site also offers a 100 percent money-back guarantee within 30 days if the consumer is not fully satisfied for any reason.

Additionally, the educational content available on CBD.co is written by well-trained and highly educated health experts, and all of the information has been reviewed by Eqova’s quality and compliance team.

The idea behind CBD.co is to protect consumers and arm them with helpful, educational and transparent information from CBD brands that have met Eqova’s standards and expectations. For those desiring to become educated about CBD and to add it to their supplement routines, CBD.co is a standout, one-stop resource.

For more information, visit CBD.co. To learn more about Grey Cloak Tech and Eqova, visit their respective websites at www.GreyCloakTech.com and www.Eqova.com

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• Substance use disorder (SUD) has reached crisis proportions
• Deal links Quoin’s non-opioid analgesics to Skinvisible’s drug delivery system
• Market for opioids is currently about $6 billion annually

Opioids are killing Americans at an alarming rate. Every day ‘91 Americans die… from an opioid overdose’, according to the Centers for Disease Control and Prevention (CDC). In response to the substance abuse epidemic sweeping the nation, Congress passed the 21st Century Cures Act, which was signed into law by President Obama in December 2016. The legislation allocates over $1 billion to a variety of programs, some of which will attempt to wean patients away from addictive opium derivatives, a push unlikely to cause any degradation in pain management regimens. Non-opiates, in many instances, have proven to be just as effective for pain relief as oxycodone, hydrocodone or codeine, some widely used opioids. In October 2017, President Trump declared a public health emergency to deal with the opioid epidemic. Now that opioid use has reached crisis levels, bringing benign alternatives to market could rescue thousands from the perils of addiction. Skinvisible, Inc. (OTCQB: SKVI) plans to do exactly that. It is teaming up with Quoin Pharmaceuticals, in a proposed merger, to provide pain management products that, unlike opioids, do not provide a cure that is worse than the disease.

The abuse of opioids and other substances continues globally to be a vexing public health issue. The number of people reporting a substance use disorder (SUD) is on the rise, a development attributed to illicit opioids like heroin and opium but also, more alarmingly, to prescription opioid pain relievers (OPRs). The effects have been devastating. In 2015, 33,091 Americans died due to an accidental or unintentional opioid-related overdose. OPR abuse is largely responsible for the increase in SUD fatalities. ‘Deaths from prescription opioids—drugs like oxycodone, hydrocodone, and methadone—have more than quadrupled since 1999’, according to one CDC study (http://dtn.fm/q4SKb). This fourfold increase is in line with the volume of OPRs dispensed: ‘The amount of prescription opioids sold to pharmacies, hospitals, and doctors’ offices nearly quadrupled from 1999 to 2010’, a development that has been blamed on system failure (http://dtn.fm/3rDPp). There is, obviously, a pressing need for less pernicious painkillers. Luckily, there are indications that some non-opiates can be just as effective at reducing pain, as a recent study shows (http://dtn.fm/7JdGR).

Announcing the proposed merger with Quoin Pharmaceuticals Limited, Skinvisible provided an update on how it proposes to address this crisis (http://dtn.fm/P4Dtj). The proposed first lead product, QRX001, is a single use transdermal non-competitive NMDA receptor antagonist intended for the treatment of post-surgical pain. An NMDA receptor antagonist is a type of anesthetic that inhibits the action of the N-Methyl-D-aspartate receptor (NMDAR). Transdermal medicines are those applied to the surface of the skin that then penetrate into the blood stream. QRX001 is expected to provide up to 72 hours of effective analgesia post-surgically, eschewing the use of any opioid.

About half of those addicted were first introduced to opioids to combat pain after surgery. QRX001, when developed, may provide surgeons with a more effective alternative to opioids and to current opioid sparing products such as intravenous NSAIDs. The current market for opioids in the U.S. is estimated at $6 billion annually, and the highly differentiated nature of QRX001 could position it to capture significant market share either as a monotherapy or as part of multi-modal therapy. An application for Fast Track status for QRX001 will be filed.

The proposed merger with Quoin will allow Skinvisible to enter the post-surgical pain management market. The post-merger entity is expected to carry the name Quoin Pharmaceuticals Inc. and be listed on the OTCQB Venture Market.

For more information, visit the company’s website at www.Skinvisible.com

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