• Currently, nuclear power is the nation’s 2nd largest source of electricity production, providing 20% of the nations’ total generation
• As a result of its carbon-free, emission free attributes, nuclear power is likely to grow with the new Administration’s clean energy initiatives, including those supporting a transition to more EV’s
• Nuclear energy is America’s largest source of carbon-free energy and its largest source of baseload power that isn’t a fossil fuel source
• UEC has a near-term production profile of 4 million pounds U3O8 per year via its low cost, environmentally friendly In-Situ Recovery (“ISR”) projects in Texas and Wyoming

With every changing presidential administration, investors glean as much information as possible from previous policies and campaign promises in order to be best positioned for industries that should prosper under new leadership. In the case of nuclear energy, not much has changed with the transition to a new Presidential administration. This topic and others were recently discussed in a virtual fireside chat between BMO Capital Markets Mining Analyst Alexander Pearce and Spencer Abraham, Chairman of Uranium Energy (NYSE American: UEC) and former United States Secretary of Energy (https://ibn.fm/OdN7N).

“They get to the same place, maybe with different pathways,” said Secretary Abraham. He expounded that contrary to the previous “all of the above” approach to U.S. energy independence, the current administration has a preference for alternative energy sources, stepping away from fossil fuel sources. The baseload power demand at the global level means that nuclear power remains a centerpiece as the largest baseload power supplier that isn’t a fossil source.

Nuclear energy currently provides about 20 percent of the electricity used in the U.S., is the nation’s second largest source of power and its largest source of emissions free energy.  Furthermore, it is highly reliable, with capacity factors greater than 92%, generating 24-7 baseload power.   Against the backdrop of a growing electric vehicle fleet, electricity required for charging stations will add to demand, particularly at night, or generally “off peak” times when EVs will be plugged in.

In other words, the future of nuclear energy remains bright. In fact, Secretary Abraham foresees a period of strong growth and a renaissance for the nuclear sector. Innovation will be encouraged in the field of nuclear energy as part of his climate-friendly initiatives.

In the video, the gentlemen also discussed the U.S. Uranium Reserve Initiative, a version of the strategic petroleum reserve considered critical to U.S. national security, to begin restoring a domestic supply chain instead of the current model of overdependence on foreign suppliers that are providing about 99 percent of the nation’s uranium.

This is expected to be beneficial to Corpus Christi-based UEC, which owns or controls uranium projects in Texas (Hobson Processing Plant, Palangana, Goliad, Burke Hollow, Salvo, Longhorn), Wyoming (Reno Creek), New Mexico (Dalton Pass, C de Baca), Colorado (Long Park, Slick Rock) and Arizona (Anderson, Los Cuatros, Workman Creek), in addition to two projects in Paraguay and another in Canada. The Reno Creek project is the largest permitted, pre-construction ISR uranium project in the U.S.

The Uranium Reserve is only a first step in a changing the nuclear fuel supply chain landscape, according to Secretary Abraham. The new Administration has pledged to examine a litany of supply chain challenges for vital minerals. As that review happens, it will highlight the need to ensure the U.S. has access to all components in the nuclear fuel supply chain from uranium to enrichment capacities. This too will be positive for UEC and others in the space.

UEC has amassed a substantial portfolio of ISR uranium reserves in the U.S. with near term annual production estimated at 4 million pounds of U3O8 from the projects in Texas and Wyoming. In ISR mining, uranium is extracted through a series of injection and production wells in a process that is similar to a water softener. The process is known to be a more environmentally friendly and cost-effective recovery process than conventional mining.

Going forward, Secretary Abraham sees a lot of positives for the industry with the new Administration. He noted that there is already a trend shift amongst former opponents of nuclear energy that have come to recognize that nuclear energy is clean energy. He expects that trend to continue and accelerate as the new Administration enforces climate friendly policies, which will lead to additional investment in the industry.

For more information, visit the company’s website at www.UraniumEnergy.com.

NOTE TO INVESTORS: The latest news and updates relating to UEC are available in the company’s newsroom at https://ibn.fm/UEC

• Imagin Medical is a surgical company focused on developing its i/Blue(TM) Imaging System, employing patented ultrasensitive imaging technology
• The i/Blue(TM) Imaging System is system compatible; system attaches to most endoscopes
• The company recently closed the second tranche for the amount of US$1,415,500 of the Convertible Note offering

Imagin Medical (CSE: IME) (OTCQB: IMEXF) is a surgical imaging company focused on advancing new methods of visualizing cancer during minimally invasive surgical procedures. Imagin Medical is run by an experienced management team that is preparing their i/Blue(TM) Imaging System for the industry. An FDA approval process is underway. The company’s patented ultrasensitive imaging product, the i/Blue(TM) Imaging System, based on optics and light sensors, has potential early-stage cancer-detection abilities. The company’s first target for treatment is bladder cancer. The Patented i/Blue(TM) Imaging System White light cystocopy does not always discern cancer from healthy tissue. The company hopes to overcome this handicap using its advanced patented ultrasensitive imaging product, the i/Blue(TM) Imaging System (https://ibn.fm/0qXzk). Imagin Medical uses Blue Light technology that combines the improved image quality of blue light with the location orientation that white light provides. The device uses an already FDA-approved contrast agent, that is administered through a catheter one hour before the surgery. The i/Blue(TM) Imaging System is compatible with most endoscopes through the plug-and-play method. The surgeon can simultaneously view both white and blue light video streams in a single frame and in real-time on the surgical monitor, without having to toggle between the two images. The company believes this breakthrough technology will advance the accuracy and efficiency of bladder cancer detection and removal. And potentially reduce bladder cancer recurrence rates and as well as healthcare costs (https://ibn.fm/Qg9R3). In a recent announcement made by Imagin Medical, the company stated that it has closed the second tranche of US$1,415,500 of the Convertible Note offering. Total Convertible Note amount of $2,165,500 raised earlier this year (https://ibn.fm/KyKxg). Imagin Medical’s Focus on Surgical Imaging Market The global endoscopy market is valued at $46B. Imagin’s bladder cancer target is estimated to be a $400M slice of this market. The demand for improved visualization during Minimally Invasive Surgery (“MIS”) has increased manifold in recent years. MIS is less painful, offers speedy recovery, and cost-savings. For more information, visit the company’s website at www.ImaginMedical.com. NOTE TO INVESTORS: The latest news and updates relating to IMEXF are available in the company’s newsroom at https://ibn.fm/IMEXF

• GRYN closes acquisition of assets of leading hemp supply cultivation and company Primordia
• “We are at the forefront of a growing, dynamic new sector within the biotech industry,” says CEO
• Green Hygienics focused on building strong portfolio in industry expected to reach $15.26 billion by 2027

Green Hygienics Holdings (OTCQB: GRYN) has been working for months to reach an objective — a goal that the company accomplished with the recent announcement that it had closed on the acquisition of certain assets of Primordia (https://ibn.fm/QTc62). This strategic move brings GRYN a significant step closer to its goal of building a portfolio of e-commerce sites that target specific market segments and expanding its supply chain potential. The assets acquired through the transaction include Primordia inventory, equipment, brands and trademarks, plus an e-commerce site, customer base and relationships that provide the potential for up to 10,000 acres of contract cultivation. “We are at the forefront of a growing, dynamic new sector within the biotech industry,” said Green Hygienics CEO Ron Loudoun. “The demand side continues to grow rapidly, while on the supply side the learning curve is steep and opportunities for valued acquisitions will arise. Our first e-commerce site is for the boutique brand Sol Valley Ranch, and the Primordia acquisition will target farm-direct bulk wholesale buyers. When you consider the improved ROI created through sales of finished product, it makes sense to develop or acquire a portfolio of e-commerce sites that target specific market segments. This acquisition will generate immediate cash flow for Green Hygienics.” A seed-to-soil, single-origin hemp supply company, Primordia intends to continue operation but under a different name. The acquisition agreement also noted that it will not compete with Green Hygienics in this sector. Green Hygienics’ strategic focus on building a strong portfolio bodes well for the company as it strengthens its position in the hemp industry, which is expected to reach $15.26 billion by 2027 (https://ibn.fm/Wvx2J). GRYN plans to build that portfolio by finding, acquiring and developing strategically positioned businesses; the company is also looking for the best innovations within the hemp industry. The company’s corporate mission is to adhere to the highest standards of operations in consistently delivering safe and premium-quality products to consumers as well as to partner with consumer packaged goods (“CPG”) and pharmaceutical companies. As it focuses on this mission, Green Hygienics will leverage its state-of-the-art technologies to open a new world of novel cannabinoids and targeted biodelivery systems designed to solve the pressing issues of stability, pharmacokinetics, biological tissue penetration and bioavailability. GRYN’s commitment to become the most highly certified hemp company in the industry offers investors an opportunity to connect with a company dedicated to delivering safe and premium quality products to consumers as well as CPG and pharmaceutical companies. With FDA certifications to prove the highest operating standards, Green Hygienics seems well positioned to offer growth potential in a market that is demanding quality. For more information about this company, visit www.GreenHygienics.com. NOTE TO INVESTORS: The latest news and updates relating to GRYN are available in the company’s newsroom at http://ibn.fm/GRYN

• InsuraGuest Technologies is a leading insurtech (insurance + technology) company that offers Hospitality Liability coverage for the hotel and vacation rental markets, utilizing its proprietary software platform
• The company is looking to enter the European and Canadian markets in 2021, according to their latest press release
• The two markets offer promise, given the size of the SMEs and projections on revenue generated from the traditional hospitality sector and vacation/holiday rental homes
• InsuraGuest already has existing insurance partnerships with leading underwriting companies, and distribution with leading insurance agencies

The world of insurance is experiencing a shakeup thanks to technology. At the center of this reorganization is InsuraGuest Technologies (TSX.V: ISGI) (OTCQB: ISGIF), a leading insurtech company transforming the way insurance is delivered. InsuraGuest accomplishes this using a proprietary software platform that delivers digital insurance to multiple sectors, making it well-suited for the current insurance market conditions. A McKinsey report on the digital disruption in insurance terms the present era as “The age of innovation. Insurers have a choice: be disrupted or be the disruptor with new products, services, and business models.” It further discussed new ways in which technology has disrupted and is disrupting the insurance sector, among them the fact that new underwriting approaches have emerged. One such disruption, which InsuraGuest’s products happen to be a part of, is on-demand insurance. The report continues, “In addition to facilitating the underwriting of small amounts of cover, real-time data can enable the provision of ‘episodic’ or on-demand cover for short periods” (https://ibn.fm/gvPqY). This statement perfectly describes InsuraGuest’s products. Further, ISGIF’s software platform supports multiple property management systems used in the hospitality industry – over 82 PMS systems available in the market – through back-end integration, enabling it to deliver the Hospitality Liability coverage. This coverage, a specialized insurance policy covering property, casualty, accidents, and health claims, is activated when a guest checks in and deactivates once they check out. This insurance policy is also unique because it passes the cost to the guest (https://ibn.fm/jlR9d) and is available for hotels and vacation rental properties. In a presentation to insurance brokers published on December 2, 2020, InsuraGuest announced it would be expanding to Europe and Canada in 2021 (https://ibn.fm/pZhFa). A look at the European and Canadian markets shows the motivation behind this expansion drive. A publication by the European Commission shows that small and medium-sized enterprises (“SMEs”) contribute 50% of Europe’s GDP. As at March 2020, there were 25 million SMEs, which employed 2 out of 3 Europeans (https://ibn.fm/mLFm0). The European vacation/holiday rental homes are projected to generate about $23.99 billion in revenue in 2021, with the figure expected to reach $34.18 billion by 2025 (https://ibn.fm/xq58u). The revenue from Canadian holiday rental homes is forecasted to reach $1.40 billion in 2021 and $1.90 billion by 2025 (https://ibn.fm/JHckW). These figures exclude the income from the traditional hospitality industry, which is expected to generate $79 billion and $4.89 billion in 2021 in Europe and Canada, respectively. To back this expansion, InsuraGuest already has existing partnerships with underwriters in these new markets and distribution through major insurance agencies. Therefore, they looks well-positioned to enter the new market successfully. InsuraGuest is transforming the way insurance is delivered, and the fact that it is eyeing new markets means that it is looking at the transformation from a global perspective. For more information, visit the company’s website at www.InsuraGuest.com. NOTE TO INVESTORS: The latest news and updates relating to ISGI are available in the company’s newsroom at http://ibn.fm/ISGI

• Company provides people living plant-based lives with extensive, customized e-commerce experience
• Online platform features more than 5,000 plant-based products with more added daily
• Meal delivery is currently available throughout Canada with plans to expand into U.S. starting spring 2021

PlantX Life (CSE: VEGA) (Frankfurt: WNT1) (OTCQB: PLTXF) is redefining the plant-based community through e-commerce. The company provides people living plant-based lives with multiple products, meals, recipes and more through e-commerce and brick-and-mortar stores. PlantX is one of the first-known public companies entirely focused on the plant-based e-commerce space. The company’s easy-to-use, e-commerce shopping experience provides consumers in Canada and the United States with an extensive range of product categories. The one-stop online shop for everything plant-based features plant-based grocery items, meal delivery, affordable indoor plants and a large library of easy-to-follow recipes. The online shop features more than 5,000 plant-based products with an item list that is continually growing. There is a full repertoire of high-quality products available that range from pantry items, beauty products and pet supplies. Consumers can browse by category, brand, price or even dietary preference. The shopping experience is tailored to the customer, whether gluten free, paleo friendly, nut free or any number of other dietary configurations. Visitors to the site can even browse a gifting section with a wide range of gift baskets to send to loved ones — or themselves. The plant shop has a large selection of indoor plants to choose from, available from seed to full grown, with a featured list of plants that changes every month. Consumers can search for the perfect plant based on the qualities they wants to add to their home. Whether shoppers are concerned about the plant being pet friendly, wishing to add immune-boosting properties to their home, or wanting to purify the air, PlantX helps them pick the right indoor plant. The meal delivery service delivers delicious 100% plant-based, meat-alternative meals to consumers’ homes throughout Canada. The company is expanding this service into the United States in spring 2021. Each meal is created by renowned chefs around the world. For those who do not yet have access to the meal delivery, there’s no need to worry. The company has an extensive library of free plant-based recipes on its website. With its fast-growing category verticals, PlantX offers customers across North America more than 5,000 plant-based products. In addition to offering meal and indoor plant deliveries, the company currently has plans to expand its product lines to include cosmetics, clothing and its own water brand. PlantX uses its digital platform to build a community of like-minded consumers and, most importantly, provide education. For more information, visit the company’s websites at www.PlantX.com, www.PlantX.ca and www.Investor.PlantX.com. NOTE TO INVESTORS: The latest news and updates relating to PLTXF are available in the company’s newsroom at https://ibn.fm/PLTXF

• Gold reached historic highs in 2020, is predicted to surpass $3,100 per ounce by 2026
• Mining companies are worth value of their reserves; GOH has seven promising projects in play
• GOH is committed to spending responsibly, incentivizing management for success

GoldHaven Resources (CSE: GOH) (OTCQB: GHVNF) (FSE: 4QS) is a junior gold mining company based in Canada that acquires and explores mineral resource properties. The company has acquired seven advanced gold projects in the Maricunga Gold Belt in Northern Chile, with four of those categorized as high-priority sites. GoldHaven seeks to identify and capitalize on valuable precious metal projects in mineral-rich districts with stable political jurisdictions while offering shareholders continued value. Throughout the COVID-19 pandemic, gold has shown itself to be a money-making proposition in a highly volatile and uncertain market. In 2020 gold reached historic highs, topping $2,000 per ounce. Wallet Investors predicts gold to rise over the next five years, surpassing $3,100 per ounce by 2026 (https://ibn.fm/qZTMA). An article in “Forbes” notes that a gold mining company is worth the value of its gold reserves, meaning the gold in the ground (https://ibn.fm/BpxbY). This makes junior gold mining companies worthy opponents in the industry and attractive assets to larger players in the space. With seven promising sites along the Maricunga Gold Belt, GoldHaven is positioned as a strong contender in the industry. In a continued effort to deliver shareholder value, GoldHaven is committed to spending responsibly, keeping salaries at a minimum and incentivizing management to participate in the overall success of the company (https://ibn.fm/7nBEi). “The GOH story has evolved from an asset acquisition story in 2020, to a fully funded and drill ready exploration play in 2021,” stated GoldHaven CEO Daniel Schieber in a recent press release (https://ibn.fm/Oxi5m). GoldHaven has strong profit potential with four high-priority targets. Its Rio Loa Project has entered phase 1 of the drill program while the Coya, Alicia and Roma projects have been mobilized to begin trenching. These sites have been identified as high priority due to the extensive pervasive alteration, favorable geology, highly anomalous rock geochemistry results, and relative proximity to existing deposits. All seven of GoldHaven’s projects in Chile sit on the Maricunga Gold Belt in near proximity to already proven mineral-rich deposits. These seven sites are considered low risk and high quality in a stable political jurisdiction, giving the GoldHaven a unique advantage as a junior mining company in the industry (https://ibn.fm/aEDzJ). For more information, visit the company’s website at www.GoldHavenResources.com. NOTE TO INVESTORS: The latest news and updates relating to GHVNF are available in the company’s newsroom at http://ibn.fm/GHVNF

• SHRG has launched new brand identity, the Happy Co.
• New brand designed to convey core values — happiness, family and community — reflecting emerging shift in consumer behavior
• Rebranding is part of wider strategy to accelerate international growth

Sharing Services Global (OTCQB: SHRG), a publicly traded company specializing in the direct-selling industry and network marketing, has unveiled the new brand identity of its wholly owned subsidiaries Elevacity Holdings LLC and Elevacity U.S. LLC, now known as the Happy Co. (https://ibn.fm/XUyUg). “The Happy Co. is not just a name; it is the best descriptor of our mission. It directly mirrors our values and purpose of sharing happiness through products and experiences that elevate lives,” said Bo Short, CEO of Elevacity Holdings LLC and Elevacity International Holdings LLC. “Our brand partners and our customers live this experience every day. This new branding is an important step as we begin our global expansion in 2021. It connects perfectly to our enhanced business platform and ever-growing ecosystem of products.” After the recent announcement of the upcoming rebrand, the new brand identity was fully unveiled this week. The leading producer of nootropic, functional health and wellness products now offers revamped digital experience for customers and brand partners alike. The new rebranding strategy involves a complete overhaul of both the consumer-facing and business websites. The former is created to be the place where customers purchase Happy Co. products, while the latter is imagined as the hub showcasing the business opportunity. New brand colors, logo and images are rich with happiness, reflecting the founding principle of the Happy Co. — that everyone deserves to be happy. The new brand look and feel are designed to communicate the happiness and well-being that lies at the crux of the Sharing Services’ identity, reinforcing the vital role of family and community as core values that underpin the company’s strategy. SHRG is proving again that it is a quick mover that adjusts effectively to emerging market demand as studies show that health awareness and community are key building blocks of new consumer behavior (https://ibn.fm/WqhOz). The result of a six-month creative process with BVA agency — one of the major players in the digital marketing space — the new brand identity radiates the happiness and warmth of the community. A revamped digital platform that supports technical aspects including order fulfillment, payments, commissions, reporting and customer relationship management (“CRM”) was developed by Exigo, the direct-selling industry leader that ensured frictionless customer experience during the complete online buyer’s journey. “It feels wonderful to establish this alignment between our purpose and our branding,” said Garrett McGrath, president of the Happy Co. “We’ve been called the ‘Happy Coffee Company’ for years and now we are able to realize our brand recognition and leverage it. I am so proud of the dedication and thoroughness our team put into making this new brand a reality.” The new branding is launched as an integral part of the Sharing Services’ efforts to accelerate growth in the international landscape. Designed to emanate a pleasant feeling, the branding works hand-in-hand with the company’s offering developed to fuel customers for the good life. The new branding ideally reflects the SHRG’s inner personality with products designed to elevate mood, boost energy, enhance sleep, reduce stress and empower consumers to look and feel their best. With “a cup of happy and a dose of healthy,” the Happy Co. is committed to inspire the good life for its customers and grand partners alike. For more information, visit www.SHRGInc.com and www.TheHappyCo.com. NOTE TO INVESTORS: The latest news and updates relating to SHRG are available in the company’s newsroom at http://ibn.fm/SHRG

• Big data is meaningless without technology to unlock, interpret value of information
• SRAX is on leading edge of offering essential data that can transform publicly held companies
• Sequire provides key insights that help companies track investors’ behaviors and trends, then use those insights to engage current, potential investors

Data is the “oil” of the fourth industrial revolution, according to a recent “Forbes” article (https://ibn.fm/5msqb). The article, which took a close look at expected trends in big data and analytics this year, noted that many significant advancements seen in the world today would be impossible without data and the analytic technology created to interpret and understand that data. SRAX (NASDAQ: SRAX), a financial technology company that unlocks data and insights for publicly traded companies, is on the leading edge of offering essential data that can transform publicly held companies.

“Big Data is a term that’s come to be used to describe the technology and practice of working with data that’s not only large in volume but also fast and comes in many different forms,” the Forbes article states. “For every Elon Musk with a self-driving car to sell, or Jeff Bezos with a cashier-less convenience store, there is a sophisticated Big Data operation and an army of clever data scientists who’ve turned a vision into reality.

“The term Big Data itself may not be as ubiquitous as it was a few years ago, and that’s purely because many of the concepts it embodies have been thoroughly embedded into the world around us,” the article continues. “But just because we’ve heard about it for a while, though, doesn’t mean it’s old news. The fact is that even today, most organizations struggle to get value from a lot of the data they have access to. As a business practice, it’s still very much in its infancy.”

That’s where SRAX has carved a niche for itself. Through Sequire, its innovative investor intelligence and communications platform, SRAX offers publicly held companies not just essential data but incredible value from that data. Along with key data, Sequire also provides key insights that help SRAX’s client companies track their investors’ behaviors and trends and then use those insights to engage current and potential investors across marketing channels. And for a public company, engaging with current and potential investors may be one of the most valuable things big data can offer.

“We have been discussing the importance of retail investors in public companies since the inception of Sequire,” said SRAX Found and CEO Christopher Miglino (https://ibn.fm/edB6S). “It’s the very reason why we built the platform and related tools — to help companies effectively communicate with these investors. The current environment in the capital markets is only validating what we have been preaching for years.”

As companies contemplate what the new year might bring in terms of big data — or the “oil” that could keep their business running — they may do well to also consider the most effective ways they can derive value from that data. SRAX and Sequire ensure that companies not only receive big data, but they also receive big value from that data.

SRAX is currently focused on unlocking data and insights through its software-as-a-service (SaaS) platform, Sequire. Launched as a standalone platform in early 2020, Sequire now has more than 3 million investors and traders, with 91 publicly listed companies as subscribers. The explosion in growth is driven by Sequire’s extensive range of services and the client companies that have increasingly sought to adopt digital technology and the data generated from such mediums as a way of improving their engagement with customers and stakeholders alike.

For more information about SRAX and Sequire, visit the companies’ websites at www.SRAX.com and www.MySequire.com.

NOTE TO INVESTORS: The latest news and updates relating to SRAX are available in the company’s newsroom at http://ibn.fm/SRAX

• Brain cancer drug developer CNS Pharmaceuticals is finalizing preparations to begin March enrollment of patients in its potentially pivotal Phase 2 trial evaluating its promising lead candidate, Berubicin, for the overall survival improvement of glioblastoma (“GBM”) patients
• Glioblastomas are a type of brain cancer that have continued to elude effective therapy over the past century of investigation, leaving patients with expectations of approximately 15 months of survivability beyond diagnosis and recurrence after surgical removal
• A GBM patient in a small Phase 1 Berubicin safety trial 15 years ago has remained cancer-free and stable as of last November, a hint of Berubicin’s potential
• CNS Pharmaceuticals’ sublicensee partner, WPD Pharmaceuticals, is similarly preparing to launch a parallel Phase 2 adult GBM trial in Poland this year, and plans to begin a Phase 1 trial for malignant gliomas in pediatric patients by the end of the year

Glioblastoma may not be a household word but during 2020 more than 13,000 new diagnoses of the deadly brain cancer were expected to hit home for Americans, according to the National Brain Tumor Society. The service and research-funding organization reports that glioblastoma, or GBM, was first identified in scientific literature a century ago but that only four drugs and one device to treat GBM have been approved by the U.S. Food and Drug Administration (“FDA”) since then, and that none of the treatments have been able to significantly extend patients’ lives beyond a few extra months (https://ibn.fm/t9l9g). This sad fact holds true regardless of access to the best care in the world – even President Biden’s son Beau passed away from GMB, in 2015.

Texas-based biopharmaceutical company CNS Pharmaceuticals (NASDAQ: CNSP) is aggressively pursuing FDA approval for its lead drug candidate, a novel anthracycline and the first anthracycline that appears to be able to cross the blood-brain barrier to combat tumors — stepping up the cancer-fighting potential of the drug class.

CNS’ drug candidate, Berubicin, provides good reason for optimism — it was the subject of a Phase 1 safety trial conducted by Reata Pharmaceuticals approximately 15 years ago and one of the participants in the trial has remained alive and cancer-free as of the most recent evaluation late last year, while two other patients in the small study saw reductions of greater than 25 percent in the size of their tumors, one of which was an 80% reduction (https://ibn.fm/nzFPH).

CNS Pharmaceuticals has taken up the challenge of advancing the development of Berubicin for potential commercialization in treating GBM, an illness that is nearly 100 percent fatal just over a year after it’s diagnosed. Which is why an ongoing survival is so remarkable at the 15-year mark.

CNS has progressed its plans for a world-spanning Phase 2 trial, which will compare Berubicin’s response to the effectiveness level of established chemotherapy drug lomustine in 243 GBM patients. In a Feb. 25 news release, the company noted it was on track to enroll patients across approximately 35 clinical sites in the United States, and that 21 sites were already confirmed and in a start-up process (https://ibn.fm/uwU6D).

The participants for the Phase 2 study will be adult GBM patients with recurrent disease (Grade IV, as measured by the World Health Organization) after the failure of standard first-line therapy. The primary endpoint of the study is to demonstrate overall survival, “a rigorous endpoint the FDA recognizes when a statistically significant improvement can be shown relative to a randomized control arm,” the company states.

Shortly after patient screening begins, dosing will start and CNS’ sublicensee partner, WPD Pharmaceuticals, will initiate a similar Phase 2 multicenter clinical trial of Berubicin in Poland. WPD announced Feb. 24 it had completed an agreement to buy half of the batch of Berubicin manufactured in Europe for CNS by BSP Pharmaceuticals for the trial and was advancing its preparations to obtain final approvals from Polish drug oversight authorities (https://ibn.fm/FMj1y).

WPD’s plans are to not only begin both the Phase 2 adult GBM trial in the first half of the year, but also the first phase of a multicenter clinical trial by the end of the year for children with malignant gliomas — the first significant investigation at the pediatric level.

CNS’ future plans include pre-clinical evaluation of Berubicin for additional cancers of the central nervous system and brain (including other cancers metastatic to the brain), as well as expansion of the drug candidate pipeline for treating such cancers.

The FDA has granted CNS Pharmaceuticals its Orphan Drug designation for Berubicin, which allows the company seven years of marketing exclusivity upon approval of a new drug application (“NDA”). The company anticipates filing for additional patents relating to Berubicin to increase its intellectual property protections.

For more information, visit the company’s website at www.CNSPharma.com.

NOTE TO INVESTORS: The latest news and updates relating to CNSP are available in the company’s newsroom at https://ibn.fm/CNSP

• CPG partner starting TAAT rollout in Ohio, where three-quarters of CROSSMARK accounts indicate interest in carrying the cigarette alternative
• Company focused on capturing additional market share in $814 billion global tobacco industry
• CROSSMARK services 100,000-plus convenience stores across the country

TAAT Lifestyle & Wellness Ltd. (CSE: TAAT) (OTCQB: TOBAF) has announced that its flagship product — TAAT(TM), a tobacco-free, nicotine-free cigarette — will be showing up on shelves across Ohio, with plans to expand outside the state soon after (https://ibn.fm/uzi6a). The increasing visibility of the popular product comes as a result of TAAT’s agreement with Texas-based CPG sales agency CROSSMARK to distribute the game-changing new product. “These are exciting times for the company as we enter the final month of Q1 2021,” said TAAT CEO Setti Coscarella. “Now that our product line has had the opportunity to be tested by smokers aged 21+ across Ohio with consistently positive reception, we can start to roll TAAT out more aggressively with the knowledge that we have a solid product formulation and commercialization playbook. “Last week, CROSSMARK got to work introducing TAAT to its impressive portfolio of accounts in Ohio, and more than three quarters of those retailers reported an interest in carrying TAAT in their stores,” Coscarella continued. “CROSSMARK’s efforts will run concurrently with our continued in-house sales efforts and promotions for the TAAT online store. We are excited to see the impact CROSSMARK will have on the overall performance of TAAT as we continue our push to capture additional market share in the $814 billion global tobacco industry.” Response to TAAT’s flagship product is impressive. So far, more than three-quarters of Ohio retail accounts approached by CROSSMARK have said they were interested in carrying the novel cigarette alternative. In the next quarter, Crossmark plans on expanding its coverage in Ohio to cover up to 7,000 stores; the next move will be to take the product outside of Ohio. CROSSMARK directly services more than 100,000 convenience stores across the United States and has a proven track record of bringing a wide range of CPG products to mainstream retail channels including an e-cigarette product that achieved dominant market share. In addition, TAAT’s key account manager in Ohio has more than a decade of experience in sales for a major global tobacco firm and has been providing expert sales training with company reps to ensure that TAAT is positioned optimally in both the retail and consumer spaces. In addition to this face-to-face approach, TAAT is engaged in digital advertising campaigns targeting adult smokers, aged 21 and older. These efforts are all focused on TAAT achieving greater market penetration for TAAT in the $814 billion global tobacco industry. For more information, visit the company’s website at www.TAATGlobal.com. NOTE TO INVESTORS: The latest news and updates relating to TOBAF are available in the company’s newsroom at https://ibn.fm/TOBAF