• Correlate Infrastructure Partners has begun construction of a 908-kW rooftop solar project at Continental Envelope headquarters in Geneva, Illinois
• Once completed, it will power approximately 20-25% of the facility’s overall energy needs, and be one of the state’s biggest rooftop solar facilities
• Correlate’s management believes that this project is a demonstration of its commitment to designing and building customer-centric energy solutions for companies across various industries
• It also believes that it is a good example of how sustainable a large-scale industry such as printing can be when applying the best technology

On April 28, 2022, Correlate Infrastructure Partners (OTCQB: CIPI) announced its partnership with Continental Envelope to set up a 908-kW rooftop solar project at its headquarters in Geneva, Illinois. On May 5, the company announced that final engineering, permitting, and interconnection work had begun in what will be one of Illinois’ largest rooftop solar power facilities (https://ibn.fm/TJ5Q1). “Correlate Infrastructure Partners loves supporting ESG-focused businesses that are making a true difference in their industries and communities,” noted Todd Michaels, Correlate’s Chief Executive Officer (“CEO”). “This attractive project makes clear that sustainability and profitability are no longer at odds. This is a call to action, Chicagoland!” he added. Continental Envelope produces over 2 billion envelopes per year, making it one of the leading independent manufacturers of commercial envelopes since the 1930s. Some of its clients include but are not limited to Netflix, Capital One, AT&T, and American Express. The move towards clean energy shows the company’s commitment to making the planet greener and complements its “Pushing the Envelope” Community Gardens surrounding its Illinois property. This solar project is scheduled for completion by Q3 2022, and once done, it will power approximately 20-25% of the facility’s overall energy needs. It is further estimated that over the next 20 years, this project will help offset around 18,849 tons of carbon dioxide from the atmosphere, an amount equivalent to planting 282,000 trees or 42 million car miles driven. “This solution for Continental Envelope is a demonstration of Correlate’s commitment to designing and building customer-centric energy solutions that not only deliver profitable sustainability but create great jobs and visibility in the local community,” noted Jason Loyet, the director of Commercial Solar for Correlate. Correlate’s management is confident that this project proves that this kind of energy forward-thinking applies to manufacturing businesses of all kinds and sizes worldwide. It is also optimistic that, with Continental Envelope’s adoption of this green energy solution, the bar has been set to define sustainable businesses and other health programs designed to achieve net-zero carbon. “We are grateful to partner with this innovative family business that shows the printing industry can be more efficient and renewable without compromising reliability or profitability,” reckoned Mr. Michaels. For more information, visit the company’s website at www.CorrelateInfra.com. NOTE TO INVESTORS: The latest news and updates relating to CIPI are available in the company’s newsroom at https://ibn.fm/CIPI

• More than a dozen California cities are opening new recreational cannabis licensing opportunities this year, article reports
• SGMD has established a pattern of growth through the years, investing in a number of subsidiaries with active operations in the California cannabis sector
• Company also completed the acquisition of Lemon Glow and its assets, interests, property and rights

The cannabis space appears set for growth in California, according to an MJBizDaily report (https://ibn.fm/aKmrF). The potential growth bodes well for Sugarmade (OTC: SGMD), an emerging leader in the sector that is “More than a dozen California cities are opening new recreational cannabis licensing opportunities this year, either by embracing the legal marijuana industry for the first time or by increasing the number of available business permits,” the MJBizDaily article reported. “Several other cities, meanwhile, are laying the groundwork for new markets down the road by drafting and/or developing cannabis ordinances. The rollout of new adult-use markets and business opportunities come as cities across the state are eager to bring in additional tax revenue after the pandemic and other factors depleted public coffers. “The ongoing shift is a welcome sign for the state’s struggling marijuana sector, which remains forbidden in the vast majority of California cities and, at the same time, must compete against a thriving illicit market,” the article continued. “The retail expansion is far and wide, from urban centers in San Diego and San Jose to small towns such as Madera in the Central Valley and Oxnard along the southern California coast.” Sugarmade is working to position itself establish in the growing California cannabis delivery marketplace. The company has established a pattern of growth through the years, investing in a number of subsidiaries with active operations in the California cannabis sector. The company’s portfolio brands include Nug Avenue, SugarRush and Lemon Glow. Sugarmade owns a 70% stake in NUG Avenue, a cannabis delivery service based in southern California. The service offers hand-selected, top-shelf products from Stiiizy, Kanha, PlugPlay, BigChief and others. The cannabis delivery service that covers same-day service of a variety of products, including flower, pre-rolls, vapes, extracts, edibles, concentrates and capsules. The service covers delivery in Los Angeles County, Orange County, San Bernardino County and Riverside County. In addition, last year Sugarmade completed the acquisition of Lemon Glow and its assets, interests, property and rights (https://ibn.fm/8l1xt). “We are setting the stage to improve margins while expanding end-market access, and to grow, refine, produce, distribute in the largest and fastest-growing cannabis market on the planet,” said Sugarmade CEO Jimmy Chan. The acquisition was designed to position the company to achieve that objective with a significant capacity to scale as demand for California-grown cannabis is expected to grow when federal legalization takes place. Sugarmade believes these significant changes in the marketplace create an opportunity to invoke a new short-term strategy while the company’s long-term plans to cultivate at its new Lemon Glow facility are developing. In May of last year, Sugarmade closed on the acquisition of Lemon Glow Company and announced plans to acquire the necessary approvals and permits to cultivate up to 32 acres of the 640-acre property. Sugarmade is also working to obtain a conditional use permit number from the community development department of the county of Lake, California, which the company believes is an important step toward gaining the full conditional use permit that will allow cannabis cultivation on the property. In addition, for the 2022 cannabis cultivation season, Sugarmade is embarking on a new and bold strategy to enter into contract cultivation arrangements with local Lake County, California, cultivators that have decided not to engage in their own cultivation efforts this year. These operators have already made significant investments in infrastructure and have highly specialized personnel available that SGMD can utilize on a contract basis for production of cannabis. The company observed that, by contracting with the owners of these already available resources, it will gain immediate access to the marketplace based on an advantageous cost model that will place the company on par or, in some cases, at a superior cost position, when compared to many of the larger cannabis cultivation and distribution companies in the industry. Sugarmade officials are in negotiations with several local permitted and licensed operators that are agreeable to a partnership arrangement with Sugarmade to manage operations for cannabis cultivation. Officials are also in active negotiations on the distribution side of the business that will allow Sugarmade to bring this cultivated cannabis to the marketplace. Invoking this dynamic short-term strategy, while continuing to develop the company’s longer-term strategy to fully develop the large Lemon Glow property for cultivation, will allow Sugarmade to significantly advance the timeframe for gaining market share in this industry based on a cost model that will allow the company to produce strong margins this cultivation season. For more information, visit the company’s website at www.Sugarmade.com. NOTE TO INVESTORS: The latest news and updates relating to SGMD are available in the company’s newsroom at http://ibn.fm/SGMD

Regulators, banking institutions, companies, financial institutions, fintech industry leaders, analysts, and investors are invited to attend FinovateSpring 2022 being held this year at the Hilton San Francisco Union Square, San Francisco, CA. The event will be graced by all the top 10 banks in the US as well as eminent fintech dignitaries who will share valuable insights, solutions, and strategies on the future of digital finance. Finovate has been organizing fintech events for the last 10 years where the fintech community can interact with industry stalwarts as well as peers. The event will be attended by 1100+ senior attendees, with over 50% from financial institutions, 50+ demoers, 100+ insightful speakers, and 270+ financial institutions. Witness a visionary audience that will discuss all the aspects of the fintech ecosystem ranging from new technologies, and challenges to the solutions from the finest fintech experts. Enjoy a fresh new perspective on the entire fintech spectrum covering the length and breadth of insights from industry experts. Enjoy networking opportunities and live demos of innovative fintech solutions, and expert insights from fintech influencers, all under one roof at the FinovateSpring in San Francisco, CA. Connect with your favorite speakers to get expert advice for business solutions, investment scope, and other future challenges that this field presents. The Finovate event will also be live streamed so that enthusiasts around the world can follow the event. From seed startups to established entities, this forum will house a plethora of finance, tech, and fintech-related businesses. They will pitch their services and solutions in 7 minutes to get discovered by potential investors and educate the fintech fraternity about the services they offer. Investment firms looking for viable businesses to invest in can find plenty of avenues and investor opportunities in breakthrough fintech solutions pitched at the FinovateSpring 2022. The pandemic has changed the way financial in-person events function and intensified the use of digital technologies. The event will be held in person for maximum networking benefits. However, it will also feature live sessions of fireside chats, keynote speaker sessions, and discussion panels where experts will discuss strategies and offer valuable advice to the attendees. All FinovateSpring 2022 attendees can access the content on-demand for 12 months after the event. Also, they get a Finovate Edge virtual season ticket for FREE on buying a ticket to FinovateSpring 2022. Fintech has also launched a scholarship program to help budding fintech entities move forward through sustainable and equitable practices. To learn more, please visit https://informaconnect.com/finovatespring/.

The O’Cannabiz International Conference & Expo is a three-day event that will be held primarily at the International Center on Airport Road in Hall #5. During the O’Cannabiz International Conference & Expo, attendees will have the opportunity to participate in various activities, including a two-day Retail Summit and the privately ticketed Awards Gala to be held at Casa Loma and hosted by Family Feud Canada host Gerry Dee on June 1. O’Cannabiz is currently consisting of over 70 sessions with 200 speakers for 5,000 attendees being facilitated in a 100,000 square foot expo hall – with hundreds of industry networking opportunities available. The Title Sponsor for the event is ND Supplies, the official packaging partner for O’Cannabiz – with several other partners falling into categories labeled Platinum, Gold, Media, and Retail. Some of the featured exhibitors expected on-site include:

• ND Supplies
• 3M
• 420 Financial
• AAPS
• Blue Sky Organics
• Brigham
• Cannapiece
• Detonate Cannabis Agency
• HYDE Advisory & Investments
• Pure Atomist
• Tychon Packaging Inc.
• University of Waterloo
• Zenith Safety Products
• and more!

The retailers attending the two-day Retail Summit are offered free admission as long as they are based in Canada and register before the event takes place. The free admission to the summit ($149 value) does not cover retailers’ VIP Business Conference, Psychedelic Summit, or Awards Dinner Gala entry – and is limited to two free passes per retail location. Retailers also have the opportunity to sign up as exhibitors. O’Cannabiz Conference & Expo Schedule-at-a-Glance: Day 1: 8:00 am – 8:00 pm Registration hours and exhibitor load-in are available during all scheduled conference hours on day one. The VIP Business Conference is scheduled from 9:00 am to 4:30 pm, with a networking luncheon scheduled from noon to 1:30 pm. The Awards Dinner and Gala will take place at Casa Loma. They will begin with a Red Carpet Royalty Cocktail Reception promptly beginning at 6:15 pm, followed by the awards and dinner at 7:00 pm and an after party from 9:00 pm to 11:00 pm. Day 2: 7:30 am – 6:00 pm Registration hours for day two of the event will be from 7:30 am to 6:00 pm. An investor’s breakfast will be offered from 8:30 am until 10:00 am. The expo will run from 10:00 am until 5:00 pm with a “Meet the Exhibitor” Happy Hour immediately following from 5:00 pm to 6:00 pm. Both the Psychedelic Summit and Retail Summit will take place in Hall A and Hall B, respectively, from 10:00 am to 4:00 pm. Day 3: 7:30 am – 3:00 pm Registration hours for the final day of the summit will run from 7:30 am to 3:00 pm. A Balanced Breakfast: Bringing Diversity, Equity, and Inclusion to the Table breakfast will transpire from 8:30 am to 10:00 am. The expo will be operational from 10:00 am to 3:00 pm that day, and the retail summit will open from 10:30 am to 3:00 pm. O’Cannabiz reminds anyone considering attending the conference and expo that cannabis (in any form) will not be available on-site, and anyone in attendance must be 19 years of age or older. For more information or to register for the event, visit https://ocannabiz.com/.

• Tackling climate change opens up potentially compelling opportunities for growth for businesses driven by ESG values such as EverGen
• Company is eyeing growth opportunities – both nationally and internationally – as RNG gathers steam in the world’s bid to combat climate threat
• EverGen aims to unite social and environmental responsibility with market success; reports quarterly and annual financial results, announces plans to expand project pipeline

EverGen Infrastructure (TSX.V: EVGN) (OTCQB: EVGIF), an established independent renewable natural gas producer based in Canada, appears ready for rapid growth as the Company seeks opportunities to expand its market presence amid the strong global push for slashing the carbon footprint across the world. The Company recently reported financial results as at and for the three-month period and year ended December 31, 2021, highlighting important milestones achieved during the past year (https://ibn.fm/F40E0). As the climate threat becomes one of the most pressing challenges of this generation and many more to come, decarbonization of the economy becomes a crucial element of the climate change solution. The goal of greenhouse emission cuts is to slow the pace of the world’s progression toward a dangerous temperature level beyond which climate impacts could be more severe and pervasive, resulting in floods, droughts, and extreme heatwaves. Renewable natural gas (“RNG”) offers an alternative energy source generated from processing feedstocks such as animal and food waste as well as crops and crop residue. RNG solves a number of pressing environmental problems, from reducing carbon emissions to responsible waste disposal. With the Environmental, Social, and Governance (“ESG”) values deeply ingrained in the company’s business model, EverGen aims to connect social and environmental responsibility with commercial success. In 2021, EverGen generated CAD 9.6 million of revenues and CAD 2.8 million of adjusted EBITDA, in line with expectations. In addition, the Company had its public market debut during the past year. After the initial public offering in August 2021, EverGen has maintained its strong cash position, reporting cash and cash equivalents of CAD 19.6 million, restricted cash of CAD 2.7 million and a working capital surplus of CAD20.9 million as of December 31, 2021, which gives the Company a unique opportunity to execute on existing and forthcoming growth projects. The year 2021 was transformational for EverGen. It was the year when the Company laid the foundation for growth, poised to assume a leading position in the RNG infrastructure space in time to come. As a company focused on acquiring, developing, and operating a portfolio of renewable natural gas, waste to energy, and related infrastructure projects, EverGen remains committed to delivering strong shareholder returns in 2022 and beyond by leveraging a number of competitive advantages, including the established platform as the first mover in Canada, recently enhanced management team, growing project pipeline and diversified access to capital. As one of the key players in the Canadian RNG space, EverGen boasts an expanding project pipeline and ample acquisition opportunities. The Company believes that the Canadian RNG industry is ready for consolidation, offering compelling opportunities for growth through acquisition. The management team is evaluating several projects across the country in a bid to replicate what has been successful with its existing assets. In line with these efforts is the Company’s recently announced letter of intent to acquire a 67% interest in GrowTec, an Alberta-based biogas facility. This acquisition opportunity appears to be one of many EverGen intends to pursue across its domestic market, investing in genuinely sustainable operations that contribute to carbon-negative energy production and positively impact climate change initiatives. Furthermore, this Vancouver-based renewable energy producer appears to be on the path to competing on the global RNG stage as it eyes opportunities for continued growth internationally, across North America and more. To deliver on these ambitious targets, EverGen has further fortified its management team, attracting talent from across the RNG and waste management industries to support the Company in its efforts to scale the business. The team of leaders inspired by values of sustainable growth has established the company as a reliable RNG infrastructure platform that can contribute to the reduction of greenhouse gas emissions. Committed to being part of the circular economy and combating climate change toward a carbon-free future, EverGen is driven by ESG goals beyond environmental. Not only is it tackling the climate threat by producing renewable natural gas, but it also appears unequivocally committed to making a meaningful impact in the communities where it operates, helping them contribute to a sustainable future. The Company boasts a long-term partnership with First Nations and municipalities across BC that is designed to contribute to their economic and social upliftment by employing their talent and supporting social, cultural, and recreational programs targeted at these communities. For more information, visit the company’s website at www.EvergenInfra.com. NOTE TO INVESTORS: The latest news and updates relating to EVGIF are available in the company’s newsroom at https://ibn.fm/EVGIF

• SPYR Inc. is a Texas-based company dedicated to delivering quality in-demand Internet of Things (“IoT”) products for smart home and auto consumers of Apple products
• The company’s flagship products are developed by subsidiary Applied Magix, which also sources white label Apple HomeKit(TM) products and accessories
• SPYR recently announced evaluation of potential expansion into Mexico, Central Europe and Thailand to extend its global reach beyond its U.S. operations and its representative office in Hong Kong
• The company is also sharply discounting many of its products in a summer sale as it prepares to develop new upgraded versions
• SPYR has also announced that the company is working to develop new Car Play-compatible products

Apple-compatible product developer SPYR (OTCQB: SPYR) is examining opportunities to expand its reach to Latin America, Central Europe and Thailand to grant its smart home and connected car market products a global scale. The Internet of Things (“IoT”) developer already has a representative office in Hong Kong for potential supply of its Apple ecosystem tie-in solutions, which include chargers, adapters and data blockers produced under subsidiary Applied Magix as the source of white label Apple HomeKit(TM) products and accessories, as well as own-brand products. “These are markets that need to be considered for future expansion and we may as well start investigating a foundation now, with an eye towards the future,” SPYR CEO Tim Matula stated (https://ibn.fm/YwuZ4). “Applied Magix’ research and investigative efforts in this direction will help SPYR gain a worldwide footprint and potentially reach many more customers.” The company has been working to increase shareholder value through a number of product upgrades, sales and marketing efforts. “We are constantly upgrading our product pipeline, and our efforts to streamline our inventory benefit our tech-enthusiastic customers by making aggressive discounts available to them during our Summer Sales events,” Applied Magix CEO Harald Zink stated while announcing discounts of more than 50 percent on some of the company’s products in order to move them out ahead of expected improved versions (https://ibn.fm/gZFFT). “As we will continue to support all of our products, our existing customers are protected, as we do not orphan any of our products,” he added. The company announced the launch of its new development initiative to upgrade MagixDrive, the flagship product that is a wireless adapter between iPhones and vehicle CarPlay infotainment systems, in an April 21 news release that also indicated the company is preparing to develop other Car Play products. “Following the success of our MagixDrive Wireless CarPlay adapter, we are now really excited to hint at the next evolution of it, as we’ve listened to customer feedback and are looking at adding new features to this project,” Zink stated (https://ibn.fm/3Z6kd). SPYR is targeting what it regards as a significant market opportunity in creating smart hardware and software solutions exclusively for Apple customers. The company regards Apple customers as a group of consumers willing to pay for the privilege of getting higher quality out of their products, and it notes that there is a dearth of smart devices designed to properly integrate with Apple’s HomeKit. SPYR has also reported that it is evaluating the possibility of acquiring a developer of proprietary lighting technologies for the transportation and industrial industries, and the developer of a proprietary web-based software-hardware package used for asset tracking and management by the construction, agriculture, police and energy industries, among others (https://ibn.fm/ZcWtA). For product information, please see the Applied Magix website at https://AppliedMagix.com, or specific product sites:

• MagixDrive Wireless CarPlay Adapter – https://appliedmagix.com/MagixDriveBundle
• HomeKit Secure Video Camera with iCloud Storage – https://appliedmagix.com/HomeKitCamera
• Multipurpose Sensor with Alarm – https://appliedmagix.com/HomeKitAlarmSensor
• Environment and Motion Sensor – https://appliedmagix.com/HomeKitMotionSensor
• Window and Door Contact Sensor – https://appliedmagix.com/HomeKitContactSensor
• MagixBlock USB DataBlocker – https://appliedmagix.com/MagixBlock
• MagixCharge Dual USB-C Car Charger – https://appliedmagix.com/MagixCharge

For more information, visit the company’s website at www.Spyr.com. NOTE TO INVESTORS: The latest news and updates relating to SPYR are available in the company’s newsroom at https://ibn.fm/SPYR

Alternative Products Expo is coming to Medellín, Colombia, on May 21-22nd 2022. A leading organizer in the alternative industry, they’re committed to serving the community and strive to provide an exciting learning experience in a safe and conducive environment. For one, exhibitors can showcase their products, expand their market reach, and get discovered by investors and industry professionals. Sponsored by JuicyFields.io, this event is expecting 100+ vendors and 1000+ products, including other sponsoring brands such as LightFire & EZ Delta 8 Wholesale. A one-of-a-kind networking event, at Alt Pro Expo, buyers and investors seeking profitable avenues can discover some of the finest products even before they’re launched in the market. These products include Delta 8, nicotine replacements, vapes, CBD, Kratom and other botanicals, mood enhancers, hemp derivatives, energy boosters, and dietary supplements, to name a few. Alternative Products Expo offers a viable platform for building professional ties and connecting with a wider audience. Its mother company, ZJ Events, is a pioneer in organizing high-quality trade shows where each conversation leads to a potential business opportunity. After hosting a series of trade shows at top US cities, they now arrive in Medellin, where they’re fostering the local and budding alternative market! Become a part of this ever-growing community and join us at the next Alternative Products Expo in Medellín! To learn more, or to purchase your tickets, please visit altproexpo.com.

Ketamine shows promise in treating Alzheimer’s Disease, Parkinson’s Disease as well as depression, suicide ideation and more In 2021, Silo Pharma (OTCQB: SILO) entered into a joint venture with Zylö Therapeutics to “explore the clinical development of ketamine using ZTI’s Z-pod (transdermal) technology.” This innovative technology allows Silo, an early-stage biopharmaceutical company, to develop a ketamine delivery system for those suffering dysphagia, a difficulty or complete inability to swallow.(1) Silo Pharma is exploring the efficacy of ketamine in treating patients suffering from both Alzheimer’s Disease (“AD”) and Parkinson’s Disease (“PD”). Over 80% of PD patients(2) and 75% of AD patients(3) experience dysphagia. According to Dr. Jay Blankenship, Zylö Therapeutics V.P. of Business Development, “ketamine is an incredibly versatile drug that continues to show promise with new therapeutic indications.”  Eric Weisblum, CEO of Silo Pharma believes “the ability to deliver ketamine (through the skin) in a time-released manner will allow us to explore both the safety and efficacy of our therapeutics … We believe that Zylo’s patented technology will allow us to reach potential patients that suffer with dysphagia.” Currently, ketamine is administered intravenously, via bone tissue (intraosseous), intramuscularly, orally or intranasally (through the nose), methods that are impractical, painful and sometimes subject to nausea.(4) Ketamine has been available for over “half a century … first synthesized in 1962 by Calvin Stevens at Parke-Davis Co (now Pfizer) as an alternative anesthetic to phencyclidine.” Ketamine facilitates “hypnotic (sleep-producing), analgesic (pain-relieving) and amnesic (short-term memory loss) effects; no other drug used in clinical practice produces these three important effects at the same time. Ketamine is a standard in operating rooms. Due to its “bronchial dilatory profile,” ketamine is the safer choice for patients with “asthma and life-threatening acute bronchial constriction,” and is “preferred in patients with unstable hemodynamics (blood flow). Ketamine is also one of the very few drugs approved for anesthesia induction in caesarean sections. It is considered the agent of choice in children and burn victims.” () Novel ketamine uses show promise in treating PD-related depression as well as dyskinesia, resulting from the side effects of levodopa treatments. Dyskinesia includes involuntary, erratic, writhing movements of the face, arms, legs, and/or trunk. “Recent clinical findings suggest that ketamine may provide neuroprotection and reduce neuropsychiatric symptoms associated with AD.”() Neuropsychiatric symptoms include agitation, depression, apathy, delusions, hallucinations, and sleep impairment. Ketamine has also been studied to battle suicide ideation, as well as “eating disorders, problematic substance use, post-traumatic stress and anxiety…”() In October 2021, Silo entered into a sponsored research agreement with Columbia University incorporating the work of Dr. Christine Ann Denny. According to a Silo Pharma news release, “Dr. Denny’s pioneering research into whether ketamine … may improve memory retrieval, halt, or even reverse, the process of Alzheimer’s disease-related to memory loss or cognitive aging, could have life-altering implications for people suffering with everything from Alzheimer’s disease to post-traumatic stress disorder (‘PTSD’).” Weisblum said, “to be able to bring hope and possibly a therapeutic to patients suffering from Alzheimer’s disease (and potentially other ailments) is an exciting proposition for Silo Pharma. The unique compounds being developed at Columbia have shown great promise, and we look forward to continuing to explore and develop these therapeutics.” Illustration courtesy of Zylö Therapeutics. For Silo Pharma’s most recent news, click here. Silo Pharma 560 Sylvan Avenue, Suite 3160 Englewood Cliffs, NJ 07632 For more information, visit the company’s website at www.SiloPharma.com. NOTE TO INVESTORS: The latest news and updates relating to SILO are available in the company’s newsroom at https://ibn.fm/SILO

• CNS Pharmaceuticals is developing a proprietary drug candidate that has the potential to deliver a novel solution for unmet medical needs in treating an incurable brain cancer
• CNS’s drug candidate is called Berubicin, a powerful anthracycline that appears to be the first such chemotherapy agent able to successfully cross the blood-brain barrier
• Berubicin dosing has begun in a potentially pivotal global trial that is recruiting glioblastoma multiforme (“GBM”) brain cancer patients
• The FDA has granted CNS fast-track authorization in regard to Berubicin’s development, and European countries’ drug regulatory bodies are also granting authorization to advance the trial process there
• An April 14 Virtual Investor Spotlight Event provided investors with information on CNS’s efforts, and the Zoom webcast will remain viewable through July for interested parties

Investors interested in potentially getting on board with a biopharmaceutical company working to develop novel brain cancer solutions can learn about the unmet need for treating deadly glioblastoma (“GBM”) and the work CNS Pharmaceuticals (NASDAQ: CNSP) is putting into granting GBM patients new hope by reviewing a recent Virtual Investor Spotlight Event that will be viewable for the next few weeks. The spotlight event (event can be accessed at https://ibn.fm/QhlSJ, presented by corporate and private client services advisors at JTC IR showcases CNS’s novel anthracycline Berubicin, which appears to be the first anthracycline chemotherapy agent to successfully cross the blood-brain barrier in targeting tumors of the central nervous system. Neuro-oncologist opinion leader Samuel A. Goldlust, M.D., joined CNS Pharmaceuticals CEO John Climaco for the live Web event April 14, which was recorded for on-demand access through July (https://ibn.fm/7j4DD). Dr. Goldlust currently serves as the Pitkin Chair in Neuro-Oncology and the Medical Director of the Brain and Spine Institute at the John Theurer Cancer Center, and is an investigator in CNS’s global Berubicin study. Berubicin was the drug candidate subject of a small-scale Phase 1 clinical trial in 2006 that evaluated Berubicin’s safety, which was notable because one of the two dozen evaluated patients emerged cancer-free and has remained so over the subsequent 16 years. Nearly half of the trial’s patients experienced a statistically significant improvement in clinical benefit (https://ibn.fm/6Llns). GBM patients in general have a median survival rate of only 14.6 months after diagnosis, which is evidence of the need for an effective treatment for the thus-far incurable cancer. Anthracyclines like Berubicin are among the most powerful chemotherapy drugs and are effective against more types of cancer than any other class of chemotherapeutic agents, according to the company. They are designed to utilize natural processes to cause deoxyribonucleic acid (“DNA”) damage in targeted cancer cells by interfering with the action of cell-growth enzyme topoisomerase II. The potentially pivotal global trial that is currently under way began recruiting and dosing patients in the United States with Berubicin in 21-day cycles last year, and governmental approvals in European countries are advancing efforts to begin recruitment there (https://ibn.fm/pSXOP). Ultimately, more than 200 adult patients will participate in the “adaptive, multicenter, open-label, randomized and controlled study.” The company expects to report an interim analysis of its results early next year when 50 percent of the patients have reached the six-month point in their dosing regimen. Primary completion of the study is anticipated by October 2024, with final completion expected by February 2025 (https://ibn.fm/4DVcX). CNS is also in the process of developing a drug candidate labeled WP1244, which uses anthracycline and distamycin-based scaffolds to create small molecule agents and is believed to be 500 times more potent than chemotherapy agent daunorubicin in stopping tumor cell proliferation. Preclinical studies of WP1244 demonstrated high uptake in the brain with antitumor activity, according to the company, making WP1244 worth evaluating for treating brain cancers, as well as pancreatic and ovarian cancers and lymphomas. For more information, visit the company’s website at www.CNSPharma.com. NOTE TO INVESTORS: The latest news and updates relating to CNSP are available in the company’s newsroom at https://ibn.fm/CNSP

• Fan Pass Live with Artist Republik and FeaturedX is creating a 360 platform with pricing that sets them apart from competitors
• The May contest on Instagram is underway, and features Grow with Us (“GWU”) campaigns to help artists build their fanbase on Spotify/Soundcloud
• In the first 100 days, positive growth has been reflected across revenue per subscriber, spend per customer, and subscriber lifetime value
• Key metrics for social media have also seen an increase across the board

In the five months since announcing the acquisition of Artist Republik (and FeaturedX), Friendable (OTC: FDBL), and its flagship offering, Fan Pass Live artist platform, has seen increased growth in several areas, including social media reach, artist recruitment, and fan subscriptions – among other metrics. The combination of services has provided Friendable with the first 360 artist platform offering, resulting in a one-of-a-kind “anti-label” movement. Other platforms advertise a complete independent artist offering, but none compare to the offering provided by Friendable through Fan Pass Live, Artist Republik, and FeaturedX. Fan Pass Live took to Instagram (@fanpasslive) to let artists know exactly what sets them apart from their competitors:

• Price: $5.00 (Single), $11.00 (Album), $14.99 (Subscription)
• Annual Fee: $0
• Royalties Paid to Artists: 100%
• IRSC and UPC: FREE
• Promotions: Social Links, Playlisting, PR, Distribution, Ticketed Live Streaming, Revenue Building, Websites, and More

Each month, Fan Pass Live offers its artists additional revenue opportunities through contests that are posted on Instagram. For May, Fan Pass Live wants to help artists grow their fanbase. The top three artists with the highest streaming time in May will win free fan growth (Grow with Us) campaigns on Spotify/Soundcloud. First place will receive a $100 GWU campaign; second place will receive a $50 GWU campaign; third place will receive a $25 GWU campaign. Additionally, when an artist promotes three streams on Instagram and tags Fan Pass Live, they can win a free promo design (https://ibn.fm/mE4wy). Recent key metrics reported by the company about the first 100 days of growth for the year (per stripe merchant reporting) included revenue per subscriber increasing by 107.3% (an average of $10.72 per subscriber), spend per customer increasing 28.3% (an average of $34.12 per customer), and subscriber lifetime value (“LTV”) increased 168.5% (an average LTV of $214.45). “The reward of seeing results continues to motivate and point our team in the right direction, as our collective efforts of testing, iterating, testing, testing, and more testing pay off,” Friendable CEO Robert A. Rositano Jr. stated (https://ibn.fm/cgGnb). “We must constantly look at the macro vision and direction, but it’s the micro-levels of detail that provide the most valuable data as we seek the next milestones in artist sign-ups, fan engagement, and conversions to purchases of all kinds, which is what the above results are showing us.” The most recently reported social media statistics show key growth for March 2022 over February 2022:

• New Customers – increased by 55.6%
• New Subscribers – increased by 38%
• Spend per Customer – increased by 5.2%
• Revenue per Subscriber – increased by 4.2%
• Subscriber Lifetime Value – increased by 23.5%
• Subscriber Churn/Cancelation Rate – decreased by 15.6%

In an April press release discussing these metrics (https://ibn.fm/55uxk), (https://ibn.fm/OSl5n), Rositano Jr. stated that “From social media to revenue and user increases, as well as steady growth in key categories, it tells us everything we need to know about the path we are on as a Company, platform, team, and community of fledgling artists, fans and investors all seeking to facilitate the launch and discovery of artists worldwide as we build a brand that stands alongside each one.” For more information, visit the company’s websites at www.Friendable.com or www.FanPassLive.com. NOTE TO INVESTORS: The latest news and updates relating to FDBL are available in the company’s newsroom at http://ibn.fm/FDBL